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Infectious Disease: Tuberculosis

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Total 482 results found since Jan 2013.

A randomised, double-blind, multicentre, parallel-group, prospective study comparing the pharmacokinetics, safety, and efficacy of CT-P13 and innovator infliximab in patients with ankylosing spondylitis: the PLANETAS study
Conclusions The PK profiles of CT-P13 and INX were equivalent in patients with active AS. CT-P13 was well tolerated, with an efficacy and safety profile comparable to that of INX up to week 30.
Source: Annals of the Rheumatic Diseases - September 4, 2013 Category: Rheumatology Authors: Park, W., Hrycaj, P., Jeka, S., Kovalenko, V., Lysenko, G., Miranda, P., Mikazane, H., Gutierrez-Urena, S., Lim, M., Lee, Y.-A., Lee, S. J., Kim, H., Yoo, D. H., Braun, J. Tags: Open access, Editor's choice, Immunology (including allergy), Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Clinical and epidemiological research Source Type: research

A case of 'ping-pong' gaze of unknown cause
A 66 year-old Indian gentleman with a background of type II diabetes, Crohn's disease and previously treated tuberculosis presented with double vision and unsteadiness. He was found to have a right-sided internuclear opthalmoplegia (INO) along with weakness and fasciculations in the lower limbs associated with brisk reflexes and an ataxic gait. An MRI scan of the brain and spinal cord revealed multiple supratentorial and infratentorial lesions. There was a hyperintensity in the right medial longitudinal fasciculus, which was felt to explain the INO. Cord and nerve root changes were also present. A CT angiogram of the brain...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Bedford, J. Tags: Immunology (including allergy), Brain stem / cerebellum, Coma and raised intracranial pressure, Neurological injury, Trauma CNS / PNS, Ophthalmology, Radiology, Radiology (diagnostics), Trauma, Injury Association of British Neurologists (ABN) joint meet Source Type: research

Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: two-year efficacy and safety findings from AMPLE trial
Conclusions Through 2 years of blinded treatment in this first head-to-head study between biologic disease-modifying antirheumatic drugs in RA patients with an inadequate response to MTX, subcutaneous abatacept and adalimumab were similarly efficacious based on clinical, functional and radiographic outcomes. Overall, AE frequency was similar in both groups but there were less discontinuations due to AEs, SAEs, serious infections and fewer local ISRs with abatacept. ClinicalTrials.gov Identifier NCT00929864.
Source: Annals of the Rheumatic Diseases - December 4, 2013 Category: Rheumatology Authors: Schiff, M., Weinblatt, M. E., Valente, R., van der Heijde, D., Citera, G., Elegbe, A., Maldonado, M., Fleischmann, R. Tags: Open access, Immunology (including allergy), Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Congenital pulmonary tuberculosis
A one-month-old male baby born at full term, weighing 2.9 kg, presented with weight loss (2.5 kg at presentation), 15 days of fever and 5 days of cough. His respiratory rate was 74/min with minimal recessions. There was no lymphadenopathy or hepatosplenomegaly and absent Bacillus Calmette–Guérin nodule; cerebrospinal fluid examination was also unremarkable. His X-ray is shown in figure 1. Acid fast bacilli were found in gastric aspirate. He was negative for HIV. Both mother and child were started on anti-tubercular therapy and both improved. The mother's chest X-ray and sputum examination w...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 13, 2013 Category: Perinatology & Neonatology Authors: Chakrabarti, R., Mittal, M., Yadav, B. S., Wazir, S. Tags: Surgery, Journalology, Immunology (including allergy), HIV/AIDS, Pneumonia (infectious disease), TB and other respiratory infections, Pregnancy, Reproductive medicine, Child health, Infant health, Pathology, Radiology, Airway biology, Pneumonia (respirato Source Type: research

Factors associated with withdrawal of the anti‐TNFα biologics in the treatment of rheumatic diseases: data from the Hong Kong Biologics Registry
ConclusionsIn our registry, the retention rate of the anti‐TNFα agents was lowest but the incidence of tuberculosis, serious infections and infusion reaction was highest with IFX. Older female patients with RA and the use of IFX were independently associated with drug withdrawal.
Source: APLAR Journal of Rheumatology - December 30, 2013 Category: Rheumatology Authors: Chi Chiu Mok, Ka Yan Chan, Ka Lai Lee, Lai Shan Tam, Ka Wing Lee, Tags: Original Article Source Type: research

On the edge of the film...
Question 1 Select one option from the following: Morgagni hernia Intramural gas Spigelian hernia Diaphragmatic eventration Chilaiditi's sign Free intraperitoneal gas Abdominal situs inversus Bochdalek hernia Question 2 Select one option from the following: Atpyical mycobacterial infection Mycoplasma pneumonia Metastatic malignancy Tuberculosis Lymphadenitis Previous BCG vaccination Neuroblastoma Cat scratch disease Introduction Review areas: in radiology these are areas on a radiograph where pathology can be easily overlooked. The term is usually applied to the chest radiograph (CXR) where review areas include behind the h...
Source: Archives of Disease in Childhood - Education and Practice - January 13, 2014 Category: Pediatrics Authors: Williams, H. Tags: Oncology, Oesophagus, Editor's choice, Immunology (including allergy), Drugs: infectious diseases, Pneumonia (infectious disease), TB and other respiratory infections, Vaccination / immunisation, Child health, Radiology, Clinical diagnostic tests, Radiolo Source Type: research

Successful rifampin desensitization in a pediatric patient with latent tuberculosis
Source: Pediatric Allergy and Immunology - January 13, 2014 Category: Allergy & Immunology Authors: Stephanie Logsdon, Lynn Ramirez‐Avila, Mariana Castells, Anahita Dioun Tags: Correspondence Source Type: research

Design, synthesis and evaluation of acridine and fused-quinoline derivatives as potential anti-tuberculosis agents.
Abstract The synthesis of twelve acridine and polycyclic acridine derivatives prepared via the Friedländer reaction is described. The one-pot reactions of 2-amino-5-chloro or 5-nitro-benzophenones and a variety of cyclanones and indanones were carried out in a MW oven under TFA catalysis in good yields. The products were designed according natural antituberculosis products and were evaluated for growth inhibitory activity towards Mycobacterium tuberculosis H37Rv (Mtb) through the National Institute of Allergy and Infectious Diseases (NIAID, USA). Three of them underwent additional testings. The cyclopenta[b]quino...
Source: European Journal of Medicinal Chemistry - December 25, 2013 Category: Chemistry Authors: Muscia GC, Buldain GY, Asís SE Tags: Eur J Med Chem Source Type: research

Safety of synthetic and biological DMARDs: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis
Conclusions The findings from this SLR confirm the known safety pattern of sDMARDs and bDMARDs for the treatment of RA.
Source: Annals of the Rheumatic Diseases - February 4, 2014 Category: Rheumatology Authors: Ramiro, S., Gaujoux-Viala, C., Nam, J. L., Smolen, J. S., Buch, M., Gossec, L., van der Heijde, D., Winthrop, K., Landewe, R. Tags: Immunology (including allergy), Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Efficacy and safety of adalimumab in Chinese adults with active ankylosing spondylitis: results of a randomised, controlled trial
Conclusions Adalimumab significantly reduced the signs and symptoms, improved physical function and quality of life of Chinese patients with active AS, and was generally safe and well tolerated in this population.
Source: Annals of the Rheumatic Diseases - February 4, 2014 Category: Rheumatology Authors: Huang, F., Gu, J., Zhu, P., Bao, C., Xu, J., Xu, H., Wu, H., Wang, G., Shi, Q., Andhivarothai, N., Anderson, J., Pangan, A. L. Tags: Immunology (including allergy), Ankylosing spondylitis, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology, Calcium and bone Source Type: research

Vitamin A may help boost immune system to fight tuberculosis
Tuberculosis is a major global problem, affecting 2 billion people worldwide and causing an estimated 2 million deaths annually. Western countries are once again tackling the disease, with recent outbreaks in Los Angeles and London.   The rise of drug-resistant TB, called a "ticking time bomb" by the World Health Organization, and the high cost of fighting the disease highlight the need for new approaches to treatment.   In findings published in the March 1 issue of the Journal of Immunology, UCLA researchers investigating the role of nutrients in helping the immune system fight against major infectio...
Source: UCLA Newsroom: Health Sciences - February 25, 2014 Category: Universities & Medical Training Source Type: news

Fifteen-minute consultation: Bacillus Calmette-Guerin abscess and lymphadenitis
Bacillus Calmette–Guérin (BCG) vaccine contains a live attenuated strain of Mycobacterium bovis, which provides 64% efficacy against tuberculous meningitis and 78% efficacy against disseminated tuberculosis.1 A number of local adverse reactions are recognised (abscess, suppurative lymphadentitis, keloid formation). An increased number of local complications were reported in the UK and Ireland since the introduction of a new BCG strain in 2002.2 3 It is important to distinguish between a normal vaccine response, a local complication and the very rare cases of systemic BCG infection that occur with immunodeficie...
Source: Archives of Disease in Childhood - Education and Practice - May 14, 2014 Category: Pediatrics Authors: Riordan, A., Cole, T., Broomfield, C. Tags: Epidemiologic studies, Immunology (including allergy), Drugs: infectious diseases, HIV/AIDS, Meningitis, Vaccination / immunisation, Infection (neurology), Pregnancy, Reproductive medicine, Child health, Infant health, Rheumatology, Sexual health, Dermato Source Type: research

Lymphadenopathy in children: refer or reassure?
INTRODUCTION Fareed, a 15-year-old British boy of Pakistani origin, was brought to his general practitioner (GP). His parents had become concerned about a ‘lump’ which had recently appeared on his neck and had now been present for approximately 2 weeks. Fareed had been unwell in the last fortnight with a history of a mild fever, coryzal symptoms and a sore throat. These symptoms had resolved although he was still feeling quite tired. There was no history of night sweats, weight loss or pruritus and he had not noticed any unusual lumps in other places. There was no significant past medical history. Fareed w...
Source: Archives of Disease in Childhood - Education and Practice - May 14, 2014 Category: Pediatrics Authors: King, D., Ramachandra, J., Yeomanson, D. Tags: Oncology, Immunology (including allergy), TB and other respiratory infections, Vaccination / immunisation, Pain (neurology), Child health, Rheumatology, Sexual health, Dermatology, Ear, nose and throat/otolaryngology Review Source Type: research

Immune activation alters cellular and humoral responses to yellow fever 17D vaccine
Conclusion. Together, these results demonstrate that an activated immune microenvironment prior to vaccination impedes efficacy of the YF-17D vaccine in an African cohort and suggest that vaccine regimens may need to be boosted in African populations to achieve efficient immunity.Trial registration. Registration is not required for observational studies.Funding. This study was funded by Canada’s Global Health Research Initiative, Defense Threat Reduction Agency, National Institute of Allergy and Infectious Diseases, Bill & Melinda Gates Foundation, and United States Agency for International Development.
Source: Journal of Clinical Investigation - June 10, 2014 Category: Biomedical Science Authors: Enoch Muyanja, Aloysius Ssemaganda, Pearline NGauv, Rafael Cubas, Helene Perrin, Divya Srinivasan, Glenda Canderan, Benton Lawson, Jakub Kopycinski, Amanda S. Graham, Dawne K. Rowe, Michaela J. Smith, Sharon Isern, Scott Michael, Guido Silvestri, Thomas H Source Type: research

NIH scientists establish proof-of-concept for host-directed tuberculosis therapy
(NIH/National Institute of Allergy and Infectious Diseases) In a new study published in Nature, scientists describe a new type of tuberculosis treatment that involves manipulating the body's response to TB bacteria rather than targeting the bacteria themselves, a concept called host-directed therapy.
Source: EurekAlert! - Infectious and Emerging Diseases - June 26, 2014 Category: Infectious Diseases Source Type: news