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Infectious Disease: Zika Virus
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Total 36 results found since Jan 2013.
Viruses, Vol. 15, Pages 97: HLA-A, HSPA5, IGFBP5 and PSMA2 Are Restriction Factors for Zika Virus Growth in Astrocytic Cells
Conclusions: The top ZIKV dysregulated cellular networks were antimicrobial response, cell death, and energy production while top dysregulated functions were antigen presentation, viral replication and cytopathic impact. Th1 and interferon signaling pathways were among the top dysregulated canonical pathways. siRNA-mediated KD of HLA-A, IGFBP5, PSMA2 and HSPA5 increased ZIKV titers and protein synthesis, indicating they are ZIKV restriction factors. ZIKV infection also restored HLA-A expression in HLA-A KD cells by 48 h post-infection, suggesting interactions between this gene product and ZIKV.
Source: Viruses - December 29, 2022 Category: Virology Authors: Affan A. Sher Ying Tenny Lao Kevin M. Coombs Tags: Article Source Type: research
eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production
Active hypusine-modified initiation elongation factor 5A is critical for cell proliferation and differentiation, embryonic development, and innate immune response of macrophages to bacterial infection. Here, we demonstrate that both virus infection and double-stranded RNA viral mimic stimulation induce the hypusination of eIF5A. Furthermore, we show that activation of eIF5A is essential for the replication of several RNA viruses including influenza A virus, vesicular stomatitis virus, chikungunya virus, mayaro virus, una virus, zika virus, and punta toro virus. Finally, our data reveal that inhibition of eIF5A hypusination...
Source: Frontiers in cellular and infection microbiology - July 27, 2022 Category: Microbiology Source Type: research
Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
The < i > Aedes aegypti < /i > siRNA pathway mediates broad-spectrum defense against human pathogenic viruses and modulates antibacterial and antifungal defenses
by Yuemei Dong, Shengzhang Dong, Nahid Borhani Dizaji, Natalie Rutkowski, Tyler Pohlenz, Kevin Myles, George Dimopoulos
The mosquito’s innate immune system defends against a variety of pathogens, and the conserved siRNA pathway plays a central role in the control of viral infections. Here, we show that transgenic overexpression of Dicer2 (Dcr2) orR2d2 resulted in an accumulation of 21-nucleotide viral sequences that was accompanied by a significant suppression of dengue virus (DENV), Zika virus (ZIKV), and chikungunya virus (CHIKV) replication, thus indicating the broad-spectrum antiviral response mediated by the siRNA ...
Source: PLoS Biology: Archived Table of Contents - June 9, 2022 Category: Biology Authors: Yuemei Dong Source Type: research
Hemin protects against Zika virus infection by disrupting virus-endosome fusion
This study elaborated that hemin could play anti-ZIKV activity by disrupting the virus-endosome fusion process and shed new light on developing novel agents against ZIKV infection.PMID:35643150 | DOI:10.1016/j.antiviral.2022.105347
Source: Antiviral Research - June 1, 2022 Category: Virology Authors: Meng-Meng Xu Bing Wu Guan-Gen Huang Chun-Lan Feng Xiao-Han Wang Hao-Yu Wang Yan-Wei Wu Wei Tang Source Type: research
