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Infectious Disease: Hepatitis C
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Total 16439 results found since Jan 2013.
Refinement and validation of a comprehensive clinical diagnostic model (GAMAD) based on gender, age, multitarget circulating tumour DNA methylation signature and commonly used serological biomarkers for early detection of hepatocellular carcinoma: a multicentre, prospective observational study protocol
This study aims to establish a non-invasive diagnostic model for early HCC detection in the Chinese population.
Methods and analysis
This prospective, multicentre, observational study will enrol 2000 participants, including HCC patients, those with chronic liver diseases (hepatitis, cirrhosis and benign liver space-occupying lesions), and healthy individuals. The study will collect demographic data and blood samples, which will be used to test α-fetoprotein (AFP), des--carboxy-prothrombin (DCP) and circulating tumour DNA (ctDNA) methylation. The GAMAD (Gender+Age+Methylation+AFP+DCP) model involving gender, age, ctD...
Source: BMJ Open - September 18, 2023 Category: General Medicine Authors: Yang, T., Wang, N., Wang, F., Liu, H., Shen, F., Lv, G. Tags: Open access, Diagnostics Source Type: research
Analysis of the mechanism of action of Euphorbia fischeriana Steud on cirrhosis based on network pharmacology
This study aimed to employ network pharmacology to elucidate the mechanism by which Euphorbia fischeriana Steud (EFS) exhibits the efficacy on cirrhosis. The compounds and targets of EFS were retrieved from Traditional Chinese Medicine Integrated Database and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Next, these compounds and targets were analyzed based on protein-protein interaction (PPI) network. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling network was established based on KEGG database. We constructed a compound-compound target-intersection target-...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Lu Liu Yinliang Xu Liu Yang Zhenzhong Jiang Xiaoyan Li Source Type: research
MicroRNA signature from extracellular vesicles of HCV/HIV co-infected individuals differs from HCV mono-infected
J Mol Med (Berl). 2023 Sep 14. doi: 10.1007/s00109-023-02367-8. Online ahead of print.ABSTRACTHepatitis C virus (HCV) coinfection with human immunodeficiency virus (HIV) has a detrimental impact on disease progression. Increasing evidence points to extracellular vesicles (EVs) as important players of the host-viral cross-talk. The microRNAs (miRNAs), as essential components of EVs cargo, are key regulators of normal cellular processes and also promote viral replication, viral pathogenesis, and disease progression. We aimed to characterize the plasma-derived EVs miRNA signature of chronic HCV infected and HIV coinfected pat...
Source: Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Victoria Cairoli Daniel Valle-Millares Mar ía C Terrón-Orellano Daniel Luque Pablo Ryan Lourdes Dominguez Luz Mart ín-Carbonero Ignacio De Los Santos Elena De Matteo Beatriz Ameigeiras Ver ónica Briz Paola Casciato Mar ía Victoria Preciado Pamela Val Source Type: research
Stages of care for patients with chronic hepatitis C at a hospital in southern Brazil
CONCLUSION: With the elaboration of the HCV cascade of care using local data, it was possible to stratify and evaluate risk factors associated with losses between each step of the cascade, to inform new strategies to guide elimination efforts in the future.PMID:37701918 | PMC:PMC10494563 | DOI:10.4254/wjh.v15.i8.973
Source: World Journal of Hepatology - September 13, 2023 Category: Gastroenterology Authors: Manoela Badinelli Vaucher Camila Ubirajara Silva Ivana Ros ângela Santos Varella Arthur Yu-Shin Kim Dimas Alexandre Kliemann Source Type: research
People Infected With Hepatitis C May Need the Hepatitis B Shot
MONDAY, Sept. 11, 2023 -- Patients with hepatitis C should consider being vaccinated again for hepatitis B, because their immune response to the initial shot may be inadequate, a new study suggests.
Researchers at the University of Minnesota Medical...
Source: Drugs.com - Daily MedNews - September 11, 2023 Category: General Medicine Source Type: news
IHCP: interpretable hepatitis C prediction system based on black-box machine learning models
Hepatitis C is a prevalent disease that poses a high risk to the human liver. Early diagnosis of hepatitis C is crucial for treatment and prognosis. Therefore, developing an effective medical decision system i...
Source: BMC Bioinformatics - September 6, 2023 Category: Bioinformatics Authors: Yongxian Fan, Xiqian Lu and Guicong Sun Tags: Research Source Type: research
A case of difficult-to-diagnose hepatic reactive lymphoid hyperplasia finally diagnosed by using PCR analysis of IgH-gene rearrangements: a case report
AbstractReactive lymphoid hyperplasia (RLH) of the liver is extremely rare. Despite advancements in diagnostic imaging technology, it is still difficult to distinguish from hepatocellular carcinoma (HCC). Herein, we present a case of hepatic RLH mimicking HCC that was postoperatively diagnosed using several imaging modalities. A 78-year-old female was referred to our hospital with a positive hepatitis C virus antibody (HCV Ab) test. Ultrasonography revealed a 13 mm isoechoic lesion in segment 8 of the liver. Contrast-enhanced computed tomography (CE-CT) demonstrated arterial hyperintensity and washout during the later ph...
Source: International Cancer Conference Journal - September 5, 2023 Category: Cancer & Oncology Source Type: research
Transcription Factor JunB Suppresses Hepatitis C Virus Replication
Kobe J Med Sci. 2023 Aug 31;69(3):E86-E95.ABSTRACTWe previously reported that hepatitis C virus (HCV) infection activates the reactive oxygen species (ROS)/c-Jun N-terminal kinase (JNK) signaling pathway. Activation of JNK contributes to the development of liver diseases, including metabolic disorders, steatosis, liver cirrhosis and hepatocellular carcinoma. JNK is known to have numerous target genes, including JunB, a member of activator protein-1 transcription factor family. However, the roles of JunB in the HCV life cycle and HCV-associated pathogenesis remain unclear. To clarify a physiological role of JunB in HCV infe...
Source: Kobe J Med Sci - September 4, 2023 Category: General Medicine Authors: Adi Ariffianto Lin Deng Saki Harada Yujiao Liang Chieko Matsui Takayuki Abe Ikuo Shoji Source Type: research
