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Total 621 results found since Jan 2013.
Got milk? Understanding the farm milk effect in allergy and asthma prevention
Cow's milk is a major component of most of our diets, but concerns about its ingestion have been in and out of public health dialogues for decades. Raw milk has long been associated with numerous foodborne illnesses and outbreaks due to enteric and opportunistic bacteria such as Brucella, Salmonella, Listeria monocytogenes, Yersinia, Campylobactor species, Staphylococcus aureus, and Escherichia coli species.1,2 Mycobacterium bovis infection was transmitted to humans following drinking unpasteurized milk from infected cows, causing tuberculosis and scrofula.
Source: Journal of Allergy and Clinical Immunology - April 11, 2016 Category: Allergy & Immunology Authors: Joyce E. Yu, Rachel L. Miller Tags: Editorial Source Type: research
Identification of the major allergenic epitopes of Eriocheir sinensis roe hemocyanin: A novel tool for food allergy diagnoses
Publication date: June 2016 Source:Molecular Immunology, Volume 74 Author(s): Yingying Zhang, Lina Zhu, Shaoshen Li, Jiayi Zhang, Tiantian She, Juanjuan Yan, Ying Bian, Huiqiang Li Crab meat and roe are highly nutritious delicacies in China. While extensive research has been conducted for allergens derived from crab-meat, data relevant to the allergenic potential of crab roe derived proteins, of which hemocyanin is a principal contender, are almost entirely absent. Using bioinformatics prediction and IgE-binding assays, the three principal immunodominant epitopes of hemocyanin were identified and then combined as...
Source: Molecular Immunology - May 18, 2016 Category: Allergy & Immunology Source Type: research
Dust mite allergen Der f 4: Expression, characterization, and IgE binding in pediatric asthma
ConclusionsThis initial cloning and characterization of the Der f 4 allergen serves as a foundation for future studies into the clinical importance and application of this protein for house dust mite allergy.
Source: Pediatric Allergy and Immunology - May 26, 2016 Category: Allergy & Immunology Authors: Yu‐bao Cui, Li‐li Yu, Fei‐xiang Teng, Nan Wang, Ying Zhou, Li Yang, Cheng‐bo Zhang Tags: Original Article Source Type: research
Identification and Characterization of IgE-Binding Tropomyosins in Aedes aegypti
Background: The mosquito Aedes aegypti is a potential source of important clinically relevant allergens. However, the allergenicity and cross-reactivity of most of these has not been fully described. Methods: Natural wild-type mosquito tropomyosin was purified by size exclusion and anionic-exchange chromatography from an A. aegypti extract. Further characterization was accomplished by MALDI-TOF/TOF. Two recombinant variants of tropomyosin were obtained by expression in Escherichia coli. Specific IgE measurement by ELISA and skin tests for mosquito extract were performed in 12 patients with asthma or allergy rhinitis residi...
Source: International Archives of Allergy and Immunology - June 29, 2016 Category: Allergy & Immunology Source Type: research
Heat ‐labile Escherichia coli toxin enhances the induction of allergen‐specific IgG antibodies in epicutaneous patch vaccination
This article is protected by copyright. All rights reserved.
Source: Allergy - August 28, 2016 Category: Allergy & Immunology Authors: C. R. Cabauatan, R. Campana, K. Niespodziana, C. Reinisch, U. Lundberg, A. Meinke, R. Henning, A. Neubauer, R. Valenta Tags: Brief Communication Source Type: research
Patching it together: epicutaneous vaccination with heat ‐labile Escherichia coli toxin against birch pollen allergy
Source: Allergy - December 12, 2016 Category: Allergy & Immunology Authors: S. S. Killingbeck, M. Q. Ge, A. Haczku Tags: Editorial Source Type: research
Smith-Magenis Syndrome Patients Often Display Antibody Deficiency but Not Other Immune Pathologies
Conclusions Patients with SMS with heterozygous 17p.11.2 deletions display an increased susceptibility to sinopulmonary infections, but not to autoimmune, allergic, or malignant diseases. SMS sera display an antibody reactivity profile favoring neither recognition of pathogen-associated antigens nor self-antigens. Prophylactic strategies to prevent infections may also provide neurobehavioral benefits to selected patients with SMS.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 9, 2017 Category: Allergy & Immunology Source Type: research
Der f 35: an MD ‐2−like house dust mite allergen that cross‐reacts with Der f 2 and Pso o 2
ConclusionDer f 35 is a candidate major allergen from D. farinae, which is more similar to group 2 allergens from sheep scab mite and storage mites. Der f 35 could be responsible for the cross‐reactivity among group 2 mite allergens.This article is protected by copyright. All rights reserved.
Source: Allergy - April 25, 2017 Category: Allergy & Immunology Authors: Takashi Fujimura, Tsunehiro Aki, Toshihide Isobe, Akito Matsuoka, Takaharu Hayashi, Kazuhisa Ono, Seiji Kawamoto Tags: Original Article: Experimental Allergy and Immunology Source Type: research
House dust mites as potential carriers for IgE sensitization to bacterial antigens
ConclusionHouse dust mites (HDM) may serve as carriers of bacteria responsible for the induction of IgE sensitization to microbial antigens.
Source: Allergy - September 7, 2017 Category: Allergy & Immunology Authors: S. Dzoro, I. Mittermann, Y. Resch ‐Marat, S. Vrtala, M. Nehr, A. M. Hirschl, G. Wikberg, L. Lundeberg, C. Johansson, A. Scheynius, R. Valenta Tags: ORIGINAL ARTICLE Source Type: research
Distinct epitope structures of defensin ‐like proteins linked to proline‐rich regions give rise to differences in their allergenic activity
ConclusionsDespite structural similarity, different IgE‐binding profiles and proteolytic processing impacted the allergenic capacity of defensin‐polyproline–linked molecules. Based on the fact that Amb a 4 demonstrated distinct IgE‐binding epitopes, we suggest inclusion in molecule‐based allergy diagnosis.
Source: Allergy - September 27, 2017 Category: Allergy & Immunology Authors: I. Pablos, S. Eichhorn, Y. Machado, P. Briza, A. Neunkirchner, B. Jahn ‐Schmid, S. Wildner, W. T. Soh, C. Ebner, J.‐W. Park, W. F. Pickl, N. Arora, S. Vieths, F. Ferreira, G. Gadermaier Tags: ORIGINAL ARTICLE Source Type: research
Drug allergy testing and oral challenge test protocol with metronidazole
Metronidazole is the representative of nitroimidazoles the only class of medicines that is used for treatment of Trichomonas vaginalis and also a drug of choice in other infections: amebiasis; giardiasis; anaerobic bacterial and treponemal infections. Types I, II, and IV hypersensitivity reactions to metronidazole have been reported in the literature. Development of comprehensive protocol with validation of non-irritant concentrations for skin testing and intradermal testing was an unmet need that we addressed in our centre.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Michael Rudenko Source Type: research
Campylobacter infection in adult patients with primary antibody deficiency
Publication date: Available online 6 July 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jérémie Dion, Marion Malphettes, Lucie Bénéjat, Francis Megraud, Alain Wargnier, David Boutboul, Lionel Galicier, Vincent Le Moing, Patrick Giraud, Arnaud Jaccard, Raphaële Nove-Josserand, Claire Fieschi, Eric Oksenhendler, Laurence Gérard, DEFI study group
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 6, 2018 Category: Allergy & Immunology Source Type: research
A Hypoallergenic Polygalacturonase Isoform from Olive Pollen Is Implicated in Pollen-Pollen Cross-Reactivity
Conclusions: A new allergen from olive pollen, Ole e 14, has been identified, produced as a recombinant isoform, and structurally and immunologically characterized. Its role in cross-reactivity has been confirmed and, due to its smaller IgE binding capacity, it could have an important role for therapeutic purposes.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - September 2, 2018 Category: Allergy & Immunology Source Type: research
Prophylactic and therapeutic inhibition of allergic airway inflammation by probiotic Escherichia coli O83
Oral supplementation with probiotic bacteria is a promising alternative for allergy prevention. However, a recent meta-analysis has demonstrated that orally delivered bacteria only prevented the development of certain allergic manifestations, such as atopic eczema, but had limited efficacy on respiratory allergies.1 Similarly, oral delivery of the gram-negative probiotic bacterial strain Escherichia coli A0 34/86 (E coli O83; serotype O83:K24:H31; a commercially available oral live vaccine, Colinfant Newborn) to high-risk infants reduced development of atopic diseases in later life but had no beneficial effects on respiratory allergies.
Source: Journal of Allergy and Clinical Immunology - August 17, 2018 Category: Allergy & Immunology Authors: Christian Zwicker, Priya Sarate, Mirjana Drini ć, Katharina Ambroz, Elke Korb, Ursula Smole, Cordula Köhler, Mark S. Wilson, Hana Kozakova, Peter Sebo, Miloslav Kverka, Ursula Wiedermann, Irma Schabussova Tags: Letter to the Editor Source Type: research
