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Hygiene Hypothesis Indicators and Prevalence of Antinuclear Antibodies in US Adolescents
We examined associations of hygiene hypothesis indicators, including asthma, allergies, and antibodies to infectious agents, with ANA prevalence, measured by HEp-2 immunofluorescence, in adolescents (aged 12-19 years) over a 25-year time span in the National Health and Nutrition Examination Survey (NHANES) (N=2,709), adjusting for age, sex, race/ethnicity, body mass index, education and survey cycle, overall and within individual time periods, using logistic regression. Prevalence of ANA in adolescents increased from 5.0% in 1988-1991 to 12.8% in 2011-2012. ANA were positively associated with diagnosis of asthma in early c...
Source: Frontiers in Immunology - January 28, 2022 Category: Allergy & Immunology Source Type: research

The Protective Effects of < b > < i > Helicobacter pylori < /i > < /b > Infection on Allergic Asthma
As an ancient Gram-negative bacterium,Helicobacter pylori has settled in human stomach. EradicatingH. pylori increases the morbidities of asthma and other allergic diseases. Therefore,H. pylori might play a protective role against asthma. The “disappearing microbiota” hypothesis suggests that the absence of certain types of the ancestral microbiota could change the development of immunology, metabolism, and cognitive ability in our early life, contributing to the development of some diseases. And the Hygiene Hypothesis links early en vironmental and microbial exposure to the prevalence of atopic allergies and asthma. E...
Source: International Archives of Allergy and Immunology - October 20, 2020 Category: Allergy & Immunology Source Type: research

Transmaternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T cells
Transmaternal exposure to tobacco, microbes, nutrients, and other environmental factors shapes the fetal immune system through epigenetic processes. The gastric microbe Helicobacter pylori represents an ancestral constituent of the human microbiota that causes gastric disorders on the one hand and is inversely associated with allergies and chronic inflammatory conditions on the other.
Source: Journal of Allergy and Clinical Immunology - September 18, 2018 Category: Allergy & Immunology Authors: Andreas Kyburz, Angela Fallegger, Xiaozhou Zhang, Aleksandra Altobelli, Mariela Artola-Boran, Timothy Borbet, Sabine Urban, Petra Paul, Christian M ünz, Stefan Floess, Jochen Huehn, Timothy L. Cover, Martin J. Blaser, Christian Taube, Anne Müller Source Type: research

Association between infection with Helicobacter pylori and atopy in young Ethiopian children: A longitudinal study
ConclusionThese data are consistent with the hypothesis that early exposure to H. pylori is inversely associated with atopy and allergic conditions. A possible modest protective association against atopy was observed in those infected with a more virulent CagA+ strain of H. pylori.
Source: Clinical and Experimental Allergy - September 4, 2017 Category: Allergy & Immunology Authors: B. Taye, F. Enquselassie, A. Tsegaye, A. Amberbir, G. Medhin, A. Fogarty, K. Robinson, G. Davey Tags: ORIGINAL ARTICLE Source Type: research

Association between infection with H. pylori  and atopy in young Ethiopian Children: a longitudinal study
ConclusionThese data are consistent with the hypothesis that early exposure to H. pylori is inversely associated with atopy and allergic conditions. A possible modest protective association against atopy was observed in those infected with a more virulent CagA+ strain of H. pylori.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - August 8, 2017 Category: Allergy & Immunology Authors: Bineyam Taye, Fikre Enquselassie, Aster Tsegaye, Alemayehu Amberbir, Girmay Medhin, Andrew Fogarty, Karen Robinson, Gail Davey Tags: Original Article ‐Epidemiology of Allergic Disease Source Type: research

4th Pediatric Allergy and Asthma Meeting (PAAM)
DISCUSSION SESSION 1: Food allergy (PD01 –PD05)PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactionsMarta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel JuanPD02 FoxP3 epigenetic features in children with cow milk allergyLorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni CananiPD04 Combined milk and egg allergy in early childhood: let them eat cake?Santanu Maity, Giuseppina Rotiroti, Minal GandhiPD05 Introduction of complementary foods in relation to allergy and gut mic...
Source: Clinical and Translational Allergy - October 31, 2016 Category: Allergy & Immunology Source Type: research