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Source: Free Radical Biology and Medicine

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Total 199 results found since Jan 2013.

Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1 α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE.
In conclusion, our data demonstrated that ghrelin reduced oxidative stress injury and neuronal apoptosis which was in part via the GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 signalling pathway after HI. Ghrelin may be a novel therapeutic target for treatment after neonatasl HI injury. PMID: 31279091 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - July 2, 2019 Category: Biology Authors: Huang J, Liu W, Doycheva DM, Gamdzyk M, Lu W, Tang J, Zhang JH Tags: Free Radic Biol Med Source Type: research

CHK1-CENP B/MAD2 is associated with mild oxidative damage-induced sex chromosome aneuploidy of male mouse embryos during in vitro fertilization.
Abstract A high incidence of aneuploidy is observed in in vitro fertilization (IVF)-derived embryos, but the formation and repair mechanisms are unknown. Here, we investigated the effects of slightly increased reactive oxygen species (ROS) produced by in vitro culture conditions on embryo aneuploidy and the roles of the spindle assembly checkpoint (SAC) protein, mitotic arrest-deficient 2 (MAD2), and the DNA damage response (DDR) protein, checkpoint kinase 1 (CHK1), in aneuploidy repair. By assessing chromosome abnormalities via DAPI staining, karyotype analysis and next-generation sequencing technology, we demons...
Source: Free Radical Biology and Medicine - April 27, 2019 Category: Biology Authors: Huang Y, Ha S, Li Z, Li J, Xiao W Tags: Free Radic Biol Med Source Type: research

TLR4 activation alters labile heme levels to regulate BACH1 and heme oxygenase-1 expression in macrophages.
In conclusion, alterations of labile heme levels in macrophages following TLR4 stimulation play a crucial role in BACH1-mediated regulation of HO-1 expression. PMID: 31026585 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - April 22, 2019 Category: Biology Authors: Sudan K, Vijayan V, Madyaningrana K, Gueler F, Igarashi K, Foresti R, Motterlini R, Immenschuh S Tags: Free Radic Biol Med Source Type: research

Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells.
Abstract In a previous study, p21Waf1/Cip1 (p21) promoted activation of the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway, which has an important role in regulating apoptosis triggered by oxidative stress and inhibiting development of osteoporosis. Chlorogenic acid (CGA) has a strong protective effect on osteoporosis, closely related to activating the Nrf2/HO-1 pathway. However, whether CGA can resist apoptosis by regulating p21 and consequently promote activation of the Nrf2/HO-1 pathway needs further investigation. MC3T3-E1 cells were treated with dexamethasone (Dex), with or without ...
Source: Free Radical Biology and Medicine - April 16, 2019 Category: Biology Authors: Han D, Gu X, Gao J, Wang Z, Liu G, Barkema HW, Han B Tags: Free Radic Biol Med Source Type: research

Endoplasmic reticulum-associated degradation potentiates the infectivity of influenza A virus by regulating the host redox state.
Abstract During influenza A virus (IAV) infection, significant effects of oxidative stress often emerge due to the disruption of the redox balance. Reactive oxygen species (ROS) generated during IAV infection have been known to exert various effects on both the virus and host tissue. However, the mechanisms underlying the accumulation of ROS and their physiological significance in IAV infection have been extensively studied but remain to be fully understood. Here, we show that the levels of Sp1, a key controller of Cu-Zn superoxide dismutase (SOD1) gene expression, and SOD1 are mainly dependent upon the activity o...
Source: Free Radical Biology and Medicine - March 20, 2019 Category: Biology Authors: Jung KI, Shin N, Ko DH, Pyo CW, Choi SY Tags: Free Radic Biol Med Source Type: research

Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1 α in NSCLC which can be overcome by OXPHOS inhibition.
CONCLUSION: These results describe a new cisplatin resistance mechanism in NSCLC based on a metabolic reprogramming that is therapeutically exploitable through PGC-1α downregulation or OXPHOS inhibitors. PMID: 30880247 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - March 13, 2019 Category: Biology Authors: Cruz-Bermúdez A, Laza-Briviesca R, Vicente-Blanco RJ, García-Grande A, Coronado MJ, Laine-Menéndez S, Palacios-Zambrano S, Moreno-Villa MR, Ruiz-Valdepeñas AM, Lendinez C, Romero A, Franco F, Calvo V, Alfaro C, Acosta PM, Salas C, Garcia JM, Provencio Tags: Free Radic Biol Med Source Type: research

Inhibiting Inflammation and Modulating Oxidative Stress in Oxalate-Induced Nephrolithiasis with the Nrf2 Activator Dimethyl Fumarate.
This study aimed to investigate whether nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also called Nfe2l2) induced by dimethyl fumarate (DMF) could protect renal epithelial cells against oxalate-mediated injury both in vivo and in vitro. Glyoxylic acid monohydrate was intraperitoneally injected into Sprague-Dawley rats with or without intragastric administration of DMF. We showed that calcium oxalate crystallisation, accompanied by overexpression of oxidant species and inflammatory cytokines and apoptosis in the rat kidney, was partially reversed by treatment with DMF. Furthermore, oxalate induced a reduction in cell v...
Source: Free Radical Biology and Medicine - December 29, 2018 Category: Biology Authors: Zhu J, Wang Q, Li C, Lu Y, Hu H, Qin B, Xun Y, Zhu Y, Wu Y, Zhang J, Wang S Tags: Free Radic Biol Med Source Type: research

VAOS, a novel vanadyl complexes of alginate saccharides, inducing apoptosis via activation of AKT-dependent ROS production in NSCLC.
In this study, VAOS exhibited effective inhibitory effects in NSCLC both in cultured cells and in a xenograft mouse model. VAOS was further identified to induce NSCLC cell apoptosis through activating protein kinase B (AKT) to elevate intracellular reactive oxygen species (ROS) levels by increasing in oxygen consumption and impairing the ROS-scavenging system. Neither silencing of PTP1B by siRNA nor transient overexpression of PTP1B had an effect on the AKT phosphorylation triggered by VAOS, indicating that PTP1B inhibition was not involved in VAOS-induced apoptosis. Through phosphorus colorimetric assay, we demonstrated t...
Source: Free Radical Biology and Medicine - September 14, 2018 Category: Biology Authors: Zhou L, Yi Y, Yuan Q, Zhang J, Li Y, Wang P, Xu M, Xie S Tags: Free Radic Biol Med Source Type: research

Caffeic Acid Attenuates Rat Liver Injury after Transplantation Involving PDIA3-Dependent Regulation of NADPH Oxidase.
This study was undertaken to explore the effect of Caffeic acid (CA), a naturally occurring antioxidant, on I/R injury of grafted liver and the mechanisms involved. Male Sprague-Dawley rats underwent orthotopic liver transplantation (LT) in the absence or presence of CA administration. In vitro, HL7702 cells were subjected to hypoxia/reoxygenation. LT led to apparent hepatic I/R injury, manifested by deteriorated liver function, microcirculatory disturbance and increased apoptosis, along with increased PDIA3 expression and nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase activity, and membrane translocation of...
Source: Free Radical Biology and Medicine - September 12, 2018 Category: Biology Authors: Mu HN, Li Q, Fan JY, Pan CS, Liu YY, Yan L, Sun K, Hu BH, Huang DD, Zhao XR, Chang X, Wang CS, He SY, He K, Yang BX, Han JY Tags: Free Radic Biol Med Source Type: research

AMPK/PGC1 α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis.
AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. Free Radic Biol Med. 2018 Aug 30;: Authors: Liu D, Ma Z, Di S, Yang Y, Yang J, Xu L, Reiter RJ, Qiao S, Yuan J Abstract Doxorubicin (DOX) is a highly effective anticancer anthracycline drug, but its side effects at the level of the heart has limited its widespread clinical application. Melatonin is a documented potent antioxidant, nontoxic and cardioprotective agent, and it is involved in maintaining mitochondrial homeostasis and function. The present study esta...
Source: Free Radical Biology and Medicine - August 30, 2018 Category: Biology Authors: Liu D, Ma Z, Di S, Yang Y, Yang J, Xu L, Reiter RJ, Qiao S, Yuan J Tags: Free Radic Biol Med Source Type: research

F2-isoprostanes affect macrophage migration and csf-1 signalling.
F2-ISOPROSTANES AFFECT MACROPHAGE MIGRATION AND CSF-1 SIGNALLING. Free Radic Biol Med. 2018 Aug 07;: Authors: Proudfoot JM, Murrey MW, McLean S, Greenland EL, Barden AE, Croft KD, Galano JM, Durand T, Mori TA, Pixley FJ Abstract F2-isoprostanes (F2-IsoP) are formed in vivo via free radical peroxidation of arachidonic acid. Enhanced oxidative stress is implicated in the development of atherosclerosis in humans and F2-IsoP have been detected in atherosclerotic plaque. Colony stimulating factor-1 (CSF-1) is essential to macrophage survival, proliferation and differentiation and has been detected in human...
Source: Free Radical Biology and Medicine - August 7, 2018 Category: Biology Authors: Proudfoot JM, Murrey MW, McLean S, Greenland EL, Barden AE, Croft KD, Galano JM, Durand T, Mori TA, Pixley FJ Tags: Free Radic Biol Med Source Type: research

Induction of REDD1 via AP-1 prevents oxidative stress-mediated injury in hepatocytes.
Abstract Regulated in development and DNA damage responses 1 (REDD1) is an inducible gene in response to various stresses, which functions as a negative regulator of the mammalian target of rapamycin protein kinase in complex 1. In the present study, we identified the role of REDD1 under the oxidative stress-mediated hepatocyte injury and its regulatory mechanism. REDD1 protein was increased in H2O2 or tert-butylhydroperoxide (t-BHP)-treated hepatocytes. H2O2 also elevated REDD1 mRNA levels. This event was inhibited by antioxidants such as diphenyleneiodonium chloride, N-acetyl-L-cysteine, or butylated hydroxy ani...
Source: Free Radical Biology and Medicine - June 14, 2018 Category: Biology Authors: Cho SS, Kim KM, Yang JH, Kim JY, Park SJ, Kim SJ, Kim JK, Cho IJ, Ki SH Tags: Free Radic Biol Med Source Type: research

C1QTNF1 attenuates angiotensin II-induced cardiac hypertrophy via activation of the AMPKa pathway.
CONCLUSION: Our results demonstrated that C1QTNF1 improves cardiac function and inhibits cardiac hypertrophy and fibrosis by increasing and activating AMPKa, suggesting that C1QTNF1 could be a therapeutic target for cardiac hypertrophy and heart failure. PMID: 29733904 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - May 4, 2018 Category: Biology Authors: Wu L, Gao L, Zhang D, Yao R, Huang Z, Du B, Wang Z, Xiao L, Li P, Li Y, Liang C, Zhang Y Tags: Free Radic Biol Med Source Type: research

ROS Modifiers and NOX4 Affect the Expression of the Survivin-Associated Radio-Adaptive Response.
Abstract The survivin-associated radio-adaptive response can be induced following exposure to ionizing radiation in the dose range from 5 to 100 mGy, and its magnitude of expression is dependent upon the TP53 mutational status of cells and ROS signaling. The purpose of the study was to investigate the potential role of ROS in the development of the survivin-associated adaptive response. Utilizing human colon carcinoma HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures, the roles of inter- and intracellular ROS signaling on expression of the adaptive response as evidenced by changes...
Source: Free Radical Biology and Medicine - April 13, 2018 Category: Biology Authors: Murley JS, Arbiser JL, Weichselbaum RR, Grdina DJ Tags: Free Radic Biol Med Source Type: research

Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation.
In this study, we explored protective mechanisms in breast cancer cells in the setting of glucose deprivation. While breast cancer cells (MCF7 and T47D) survive in glucose-free medium for three days or more, autophagy is induced in this setting. Blocking autophagy pharmacologically with chloroquine or by knock-out of an essential autophagy gene, such as Beclin 1 or ATG7, markedly reduces the ability of cells to survive during glucose deprivation. Autophagy previously was shown to degrade p62, a protein that sequesters KEAP1, and KEAP1 in turn sequesters Nrf2, a master regulator of the antioxidant response. Hence, we invest...
Source: Free Radical Biology and Medicine - April 9, 2018 Category: Biology Authors: Walker A, Singh A, Tully E, Woo J, Le A, Nguyen T, Biswal S, Sharma D, Gabrielson E Tags: Free Radic Biol Med Source Type: research