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EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex
Conclusions: The PEI nanocomplex fabricated with EpApt and siEp was able to target EpCAM tumor cells, deliver the siRNA and silence the target gene. This nanocomplex exhibited decreased cell proliferation than the scrambled aptamer loaded nanocomplex in the EpCAM expressing cancer cells and may have potential for EpCAM targeting in vivo.
Source: Epidemiologic Perspectives and Innovations - January 9, 2015 Category: Epidemiology Authors: Nithya SubramanianJagat R KanwarPrasanna AthalyaNarayanan JanakiramanVikas KhetanRupinder K KanwarSailaja EluchuriSubramanian Krishnakumar Source Type: research

Synergistic inhibition of avian leukosis virus subgroup J replication by miRNA-embedded siRNA interference of double-target
Conclusions: These data demonstrated that the miRNA-embedded siRNA interference is an efficient method for inhibition of ALV-J replication, especially double targets.
Source: Epidemiologic Perspectives and Innovations - March 21, 2015 Category: Epidemiology Authors: Rongrong WeiXiaoqian MaGuihua WangHuijun GuoJianzhu LiuLingxiao FanZiqiang Cheng Source Type: research

Effects of hypoxia inducible factor-1α on apoptotic inhibition and glucocorticoid receptor downregulation by dexamethasone in AtT-20 cells
Conclusions: These findings strongly suggest that HIF-1α exerts an antiapoptotic role and participates in the downregulation of GR by dexamethasone in hypoxic AtT-20 cells.
Source: Epidemiologic Perspectives and Innovations - May 22, 2015 Category: Epidemiology Authors: Chenran ZhangQiang QiangYing JiangLiuhua HuXuehua DingYicheng LuGuohan Hu Source Type: research

CRTC2 enhances HBV transcription and replication by inducing PGC1alpha expression
Conclusions: Our results clearly indicate that non-phosphorylated CRTC2 strongly enhances HBV biosynthesis through inducing PGC1alpha expression. Further study of the mechanisms will elucidate the importance of metabolic signals on HBV transcription and replication, and offer insight into potential targets for developing anti-HBV agents.
Source: Epidemiologic Perspectives and Innovations - February 14, 2014 Category: Epidemiology Authors: Xiaohui TianFei ZhaoWeihua SunXiaoguang ZhiZhikui ChengMing ZhouKanghong Hu Source Type: research

Peptide deformylase inhibitor actinonin reduces celastrol's HSP70 induction while synergizing proliferation inhibition in tumor cells
Conclusions: Concurrent use of the chemical agent actinonin could reduce celastrol's HSP70 elevation and also enhance proliferation inhibition by celastrol. This combination presents a novel alternative to siRNA technology and is worth further investigation for its potentially effective anti-tumor action.
Source: Epidemiologic Perspectives and Innovations - March 4, 2014 Category: Epidemiology Authors: Bin PengXue ZhangFanfan CaoYing WangLimin XuLu CaoChunxin YangMaoquan LiGeorges UzanDenghai Zhang Source Type: research

Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer
Conclusions: Our approach has identified genes required for the migration and invasion of metastatic tumor cells, and we propose that our new in vivo model system will be a powerful tool to interrogate the metastatic cascade in prostate cancer.
Source: Epidemiologic Perspectives and Innovations - May 30, 2014 Category: Epidemiology Authors: Jacqueline BanyardIvy ChungMatthew MigliozziDerek T PhanArianne M WilsonBruce R ZetterDiane R Bielenberg Source Type: research

Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment
Conclusions: Deregulation of HDAC8 is frequent in urothelial cancer, but neither specific pharmacological inhibition nor siRNA-mediated knockdown of HDAC8 impaired viability of urothelial cancer cell lines in a therapeutic useful manner. Accordingly, HDAC8 on its own is not a promising drug target in bladder cancer.
Source: Epidemiologic Perspectives and Innovations - July 10, 2014 Category: Epidemiology Authors: Maria LehmannMichèle J HoffmannAnnemarie KochScott M UlrichWolfgang A SchulzGünter Niegisch Source Type: research

Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells
Conclusions: Our results suggest that the extracts of this polyherbal combination increase histone 3 acetylation, inhibit the expression of class I and class II histone deacetylases, increase the activation of CBP/p300 and inhibit cell proliferation, in part, by up regulating p21 expression.
Source: Epidemiologic Perspectives and Innovations - February 21, 2014 Category: Epidemiology Authors: E-Chu HuangYi ZhaoGuoxun ChenSeung Joon BaekMichael F McEnteeSteven MinkinJohn P BiggerstaffJay Whelan Source Type: research

Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells
Conclusions: Our results suggest that olaparib, a PARP inhibitor, is effective on certain endometrial cancer cell lines. Inactivation of PTEN might not affect the DNA repair function. Predictive biomarkers are warranted to utilize olaparib in endometrial cancer.
Source: Epidemiologic Perspectives and Innovations - March 13, 2014 Category: Epidemiology Authors: Aki MiyasakaKatsutoshi OdaYuji IkedaOsamu Wada-HiraikeTomoko KashiyamaAtsushi EnomotoNoriko HosoyaTakahiro KosoTomohiko FukudaKanako InabaKenbun SoneYuriko UeharaReiko KurikawaKazunori NagasakaYoko MatsumotoTakahide ArimotoShunsuke NakagawaHiroyuki Kuramo Source Type: research

PSMD9 expression predicts radiotherapy response in breast cancer
Conclusions: We conclude that PSMD9 expression may predict radiotherapy benefit, with low expression indicative of relative radio-sensitivity, the opposite of previous reports relating to 26S proteasome expression. Our conclusion is compatible with use of proteasome inhibitors as radio-sensitizers, and highlights PSMD9 as a potential target for radio-sensitizing drugs.
Source: Epidemiologic Perspectives and Innovations - March 28, 2014 Category: Epidemiology Authors: Fiona E LanglandsDavid DodwellAndrew M HanbyKieran HorganRebecca A Millican-SlaterValerie SpeirsEldo T VergheseLaura SmithThomas A Hughes Source Type: research

Repression of phosphoinositide-dependent protein kinase 1 expression by ciglitazone via Egr-1 represents a new approach for inhibition of lung cancer cell growth
Conclusion: Collectively, our results demonstrate that ciglitazone inhibits PDK1 expression through AMPKalpha-mediated induction of Egr-1 and Egr-1 binding to the specific DNA site in the PDK1 gene promoter, which is independent of PPARgamma. Activation of AMPKalpha by metformin enhances the effect of ciglitazone. In turn, this leads to inhibition of NSCLC cell proliferation.
Source: Epidemiologic Perspectives and Innovations - June 13, 2014 Category: Epidemiology Authors: SWei Sunny HannQing TangFang ZhengShunyu ZhaoJianping ChenZhiYu Wang Source Type: research

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia
Conclusions: These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via ROS-αvβ3 integrin-FAK/Pyk2 signaling pathways. This provides evidence that melatonin may be a potential therapeutic molecule targeting the hypoxic microenvironment of glioma.
Source: Epidemiologic Perspectives and Innovations - March 20, 2015 Category: Epidemiology Authors: Cheng-Shi XuZe-Fen WangXiao-Dong HuangLi-Ming DaiChang-Jun CaoZhi-Qiang Li Source Type: research

Uterine NDRG2 expression is increased at implantation sites during early pregnancy in mice, and its down-regulation inhibits decidualization of mouse endometrial stromal cells
Conclusions: These results suggest that NDRG2 might play an important role in the process of decidualization during early pregnancy.
Source: Epidemiologic Perspectives and Innovations - May 26, 2015 Category: Epidemiology Authors: Yan GuXuan ZhangQian YangJian-mei WangYa-ping HeZhao-gui SunHui-qin ZhangJian Wang Source Type: research

The novel IGF-IR/Akt-dependent anticancer activities of glucosamine
Conclusions: Taken together, our results suggest that targeting the IGF-1R/Akt pathway with glucosamine may be an effective therapeutic strategy for treating some type of cancer.
Source: Epidemiologic Perspectives and Innovations - January 20, 2014 Category: Epidemiology Authors: Ki-Hoon SongJu-Hee KangJong-Kyu WooJeong-Seok NamHye-Young MinHo-Young LeeSoo-Youl KimSeung-Hyun Oh Source Type: research

TGFbetaR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness
Conclusion: The present study reports an involvement of miR-93-mediated TGFbetaR2 down-regulation in NPC aggressiveness, thus giving extended insights into molecular mechanisms underlying cancer aggressiveness. Approaches aimed at blocking miR-93 may serve as a promising therapeutic strategy for treating NPC patients.
Source: Epidemiologic Perspectives and Innovations - March 8, 2014 Category: Epidemiology Authors: Xiaoming LyuWeiyi FangHang ZhengLongmei CaiYanfen YeLan ZhangJinbang liHong PengWilliam C ChoEna WangFrancesco M MarincolaKaitai YaoHongbing CaiJiliang LiXin Li Source Type: research

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