• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Inhibitory Effect of MicroRNA-34a on Retinal Pigment Epithelial Cell Proliferation and Migration Retinal Cell Biology
Conclusions. MicroRNA-34a is downregulated in subconfluent RPE cells. MicroRNA-34a can inhibit the proliferation and migration of RPE cells through downregulation of its targets c-Met and other cell cycle–related molecules. Our results indicated that miR-34a is involved in the regulation of RPE cells.
Source: Investigative Ophthalmology - October 3, 2013 Category: Opthalmology Authors: Hou, Q., Tang, J., Wang, Z., Wang, C., Chen, X., Hou, L., Dong, X. D., Tu, L. Tags: Retinal Cell Biology Source Type: research

Angiopoietin-Like Protein 2 Is a Potent Hemangiogenic and Lymphangiogenic Factor in Corneal Inflammation Cornea
Conclusions. Our findings demonstrated Angptl2 to be upregulated in corneal inflammation, and highlight that corneal hemangiogenesis and lymphangiogenesis may be driven by Angptk2 overexpression via macrophage infiltration and IL-1β expression. Angptl2 may be a novel therapeutic target for preventing blindness.
Source: Investigative Ophthalmology - June 26, 2013 Category: Opthalmology Authors: Toyono, T., Usui, T., Yokoo, S., Kimakura, M., Nakagawa, S., Yamagami, S., Miyata, K., Oike, Y., Amano, S. Tags: Cornea Source Type: research

Modulation of Bevacizumab-Induced Toxicity for Cultured Human Corneal Fibroblasts Cornea
Conclusions. This study determined the cellular toxicity of bevacizumab and its modulation with bFGF or NGF. Cotreatment with bFGF or NGF with bevacizumab reduced cellular damage without interfering with the original antiangiogenic function. Some components of serum have a protective effect on bevacizumab-induced corneal epithelial change.
Source: Investigative Ophthalmology - June 6, 2013 Category: Opthalmology Authors: Kim, E. K., Kang, S. W., Kim, J. Y., Min, K., Kim, T.-i. Tags: Cornea Source Type: research

Transcription Factors Runx1 to 3 Are Expressed in the Lacrimal Gland Epithelium and Are Involved in Regulation of Gland Morphogenesis and Regeneration Cornea
Conclusions. Runx1 and 2 are new markers of the LG epithelial lineage and Runx factors are important for normal LG morphogenesis and regeneration.
Source: Investigative Ophthalmology - May 1, 2013 Category: Opthalmology Authors: Voronov, D., Gromova, A., Liu, D., Zoukhri, D., Medvinsky, A., Meech, R., Makarenkova, H. P. Tags: Cornea Source Type: research

DNA-PK Phosphorylation of IGFBP-3 Is Required to Prevent Apoptosis in Retinal Endothelial Cells Cultured in High Glucose Retina Cell Biology
Conclusions. Our findings suggest Compound 49b induces DNA-PK levels through PKA activity. DNA-PK is required for Compound 49b–induced IGFBP-3 expression, leading to inhibition of REC cell death.
Source: Investigative Ophthalmology - April 30, 2013 Category: Opthalmology Authors: Zhang, Q., Steinle, J. J. Tags: Retina Cell Biology Source Type: research

Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Retina
Conclusions. Results presented in this study, for the first time, show that KA-mediated upregulation of SARM1 protein promotes Wallerian-like degeneration of RGCs and their axons.
Source: Investigative Ophthalmology - April 17, 2013 Category: Opthalmology Authors: Massoll, C., Mando, W., Chintala, S. K. Tags: Retina Source Type: research

Moesin as a key cytoskeleton regulator in corneal fibrosis.
CONCLUSIONS: : Moesin may be a potential drug target for inhibiting corneal fibrosis, and the details of moesin-related signaling pathways would be critical for understanding corneal fibrosis. PMID: 23583046 [PubMed - in process]
Source: The Ocular Surface - April 1, 2013 Category: Opthalmology Authors: Zhu HY, Yeo SW, Ng J, Htoon HM, Beuerman RW Tags: Ocul Surf Source Type: research

Epithelial Membrane Protein 2 Controls VEGF Expression in ARPE-19 Cells Retinal Cell Biology
Conclusions. This study establishes a novel connection between EMP2 and VEGF and may reflect either a direct effect through the tetraspan web or an indirect change through FAK activation. This connection is functionally significant. In addition to the direct use of anti-VEGF antibodies, modulation of EMP2 with impact on VEGF is potentially a distinct therapeutic target for the treatment of neovascularization associated with retinal diseases that involve pathologic angiogenesis.
Source: Investigative Ophthalmology - March 28, 2013 Category: Opthalmology Authors: Morales, S. A., Telander, D. G., Leon, D., Forward, K., Braun, J., Wadehra, M., Gordon, L. K. Tags: Retinal Cell Biology Source Type: research

MRP4-Mediated Regulation of Intracellular cAMP and cGMP Levels in Trabecular Meshwork Cells and Homeostasis of Intraocular Pressure Physiology and Pharmacology
Conclusions. These observations reveal that cyclic nucleotide efflux controlling transporter-MRP4 plays a significant role in IOP homeostasis potentially by regulating the relaxation characteristics of AH outflow pathway cells.
Source: Investigative Ophthalmology - March 5, 2013 Category: Opthalmology Authors: Pattabiraman, P. P., Pecen, P. E., Rao, P. V. Tags: Physiology and Pharmacology Source Type: research

MRP8/14 Enhances Corneal Susceptibility to Pseudomonas aeruginosa Infection by Amplifying Inflammatory Responses Immunology and Microbiology
Conclusions. Our study demonstrated a dual role for MRP8/14 in bacterial keratitis. Although MRP8/14 promotes bacterial clearance by enhancing ROS production, it functions more importantly as an inflammatory amplifier at the ocular surface by enhancing pro-inflammatory cytokine expression, thus contributing to the corneal susceptibility.
Source: Investigative Ophthalmology - February 12, 2013 Category: Opthalmology Authors: Deng, Q., Sun, M., Yang, K., Zhu, M., Chen, K., Yuan, J., Wu, M., Huang, X. Tags: Immunology and Microbiology Source Type: research

TGF{beta} Signaling Induces Expression of Gadd45b in Retinal Ganglion Cells Biochemistry and Molecular Biology
Conclusions. TGFβ signaling induced Gadd45b expression in RGCs. Modulation of the TGFβ/NFB/Gadd45b signaling pathway may provide a means to enhance the neuroprotective effect of Gadd45b in RGCs.
Source: Investigative Ophthalmology - February 5, 2013 Category: Opthalmology Authors: Liu, B., Sun, X., Suyeoka, G., Garcia, J. G. N., Leiderman, Y. I. Tags: Biochemistry and Molecular Biology Source Type: research

Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91.
Abstract Recent research using a rat oxygen-induced retinopathy model has demonstrated that the G protein-coupled receptor 91 (GPR91) of retinal ganglion neurons is the principal respondent to succinate and consequently induces the release of angiogenic factor vascular endothelial growth factor (VEGF). The aim of this study was to determine whether GPR91 modulate the release of VEGF from retinal ganglion cells in a high-glucose model in vitro and to dissect the role of GPR91 in the pathogenesis of diabetic retinopathy. We constructed a lentiviral small hairpin RNA (shRNA) expression vector targeting GPR91 (LV.shGP...
Source: Experimental Eye Research - February 1, 2013 Category: Opthalmology Authors: Hu J, Wu Q, Li T, Chen Y, Wang S Tags: Exp Eye Res Source Type: research

Epigenetic Modification of Sod2 in the Development of Diabetic Retinopathy and in the Metabolic Memory: Role of Histone Methylation Retinal Cell Biology
Conclusions. Histone methylation of retinal Sod2 has an important role in the development of diabetic retinopathy and in the metabolic memory phenomenon associated with its continued progression. Targeting enzymes important for histone methylation may serve as a potential therapy to halt the development of diabetic retinopathy.
Source: Investigative Ophthalmology - January 14, 2013 Category: Opthalmology Authors: Zhong, Q., Kowluru, R. A. Tags: Retinal Cell Biology Source Type: research

ERK5 Regulates Glucose-Induced Increased Fibronectin Production in the Endothelial Cells and in the Retina in Diabetes Retina
Conclusions. Our experiments demonstrated a novel mechanism of glucose-induced increased FN production in diabetic retinopathy, which is mediated through decreased ERK5 signaling.
Source: Investigative Ophthalmology - December 19, 2012 Category: Opthalmology Authors: Wu, Y., Feng, B., Chen, S., Chakrabarti, S. Tags: Retina Source Type: research

Pages: 1  2  3  4  5  6  7