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Specialty: Allergy & Immunology
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Total 828 results found since Jan 2013.
Identification and characterization of DEAD-box RNA helicase DDX3 in rainbow trout (Oncorhynchus mykiss) and its relationship with infectious hematopoietic necrosis virus infection
This study suggests that DDX3 has an important role in host defense against IHNV infection and these results may provide new insights into IHNV pathogenesis and antiviral drug research.PMID:35840014 | DOI:10.1016/j.dci.2022.104493
Source: Developmental and Comparative Immunology - July 15, 2022 Category: Allergy & Immunology Authors: Jing-Zhuang Zhao Li-Ming Xu Guang-Ming Ren Yi-Zhi Shao Tong-Yan Lu Source Type: research
Peptidoglycan-Like Components in Z-100, Extracted from < em > Mycobacterium tuberculosis < /em > Strain Aoyama B, Increase IL-12p40 via NOD2
CONCLUSION: Z-100 induced the production of immunomodulatory cytokines from various types of macrophages and specifically increased IL-12p40 production through peptidoglycan-like components via NOD2.PMID:35785036 | PMC:PMC9242757 | DOI:10.1155/2022/3530937
Source: Journal of Immunology Research - July 5, 2022 Category: Allergy & Immunology Authors: Takayuki Horii Yuki Orikawa Yuta Ohira Runa Eta Uiko Tominaga Takanori Sato Takao Tanaka Source Type: research
Stress level of glucocorticoid exacerbates neuronal damage and A β production through activating NLRP1 inflammasome in primary cultured hippocampal neurons of APP-PS1 mice
In this study, we investigated the effects of chronic GC exposure on NOX2-NLRP1 inflammasome activation and the protective effects of NLRP1-siRNA against GC-induced neuronal injury in primary hippocampal neurons of APP/PS1 mice. The results showed that chronic dexamethasone (DEX, 1 µM) exposure 72 h had no significant effect on the primary hippocampal neurons of WT mice, but significantly increased Aβ1-42 accumulation (2.17 ± 0.19 fold in APP group and 3.06 ± 0.49 fold in APP + DEX group over WT group) and neuronal injury in primary hippocampal neurons of APP/PS1 mice. Meanwhile, chronic DEX exposure significantly incr...
Source: International Immunopharmacology - July 1, 2022 Category: Allergy & Immunology Authors: Liu Yang Huimin Zhou Lei Huang Yong Su Liangliang Kong Pengmin Ji Ran Sun Chao Wang Weiping Li Weizu Li Source Type: research
EZH2 Promotes T Follicular Helper Cell Differentiation Through Enhancing STAT3 Phosphorylation in Patients With Primary Sj ögren’s Syndrome
ConclusionsEZH2 expression was abnormally elevated in pSS CD4+ T cells, which facilitated Tfh differentiation of CD4+ T cells by enhancing STAT3 phosphorylation. EZH2 promotes Tfh differentiation and might be implicated in pSS pathogenesis.
Source: Frontiers in Immunology - June 20, 2022 Category: Allergy & Immunology Source Type: research
MiR-142-5p/FAM134B Axis Manipulates ER-Phagy to Control PRRSV Replication
In this study, we found that PRRSV infection subverted ER-phagy by downregulating ER-phagy receptor FAM134B. PRRSV-induced miR-142-5p directly targeted FAM134B and significantly promoted PRRSV replication. Meanwhile, siRNA-mediated depletion of FAM134B protein and overexpression of FAM134B mutant protein significantly disrupted ER-phagy and facilitated PRRSV replication. Furthermore, our results showed that FAM134B-mediated ER-phagy activated type I interferon signaling to inhibit PRRSV replication. Overall, this study reveals the important role of ER-phagy in PRRSV replication in a FAM134B-dependent manner. Our findings p...
Source: Frontiers in Immunology - June 20, 2022 Category: Allergy & Immunology Source Type: research
Dexmedetomidine attenuates lipopolysaccharide-induced inflammation through macrophageal IL-10 expression following α7 nAchR activation
This study aimed to illustrate the molecular mechanisms underlying dexmedetomidine-induced anti-inflammation. In the LPS-pretreated mice, subcutaneous injection of dexmedetomidine reduced the spleen weight as well as serum and spleen expression of proinflammatory cytokines, tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-1β, and increased serum and spleen expression of IL-10, a known anti-inflammatory cytokine. In addition, dexmedetomidine-attenuated proinflammatory cytokine reduction was entirely inhibited by selective α7 nicotinic acetylcholine receptor (nAChR) antagonist methyllycaconitine but not α2-adr...
Source: International Immunopharmacology - June 12, 2022 Category: Allergy & Immunology Authors: Qiao-Qiao Han Xin-Yan Li Yong-Xiang Wang Source Type: research
CaMK4 Promotes Acute Lung Injury Through NLRP3 Inflammasome Activation in Type II Alveolar Epithelial Cell
ConclusionCaMK4 controls the activation of NLRP3 inflammasome in AEC II during LPS-induced ALI. CaMK4 inhibition could be a novel therapeutic approach for the treatment of ALI.
Source: Frontiers in Immunology - June 6, 2022 Category: Allergy & Immunology Source Type: research
Molecular identification and functional analysis of a tumor necrosis factor superfamily gene from Chinese mitten crab (Eriocheir sinensis)
Dev Comp Immunol. 2022 May 27:104456. doi: 10.1016/j.dci.2022.104456. Online ahead of print.ABSTRACTTumor necrosis factor (TNF) is one of the most important cytokines involved in various biological processes in vertebrates and invertebrates. In the present study, a new member of the TNF superfamily (named EsTNFSF) was identified from the Chinese mitten crab (Eriocheir sinensis). The full-length cDNA of EsTNFSF is 2462 bp and encodes a polypeptide with 499 amino acids. The deduced EsTNFSF protein contained a transmembrane region and a conserved extracellular C-terminal TNF domain. Phylogenetic analysis indicated that EsTNFS...
Source: Developmental and Comparative Immunology - May 31, 2022 Category: Allergy & Immunology Authors: Ying Huang Qin Si Shenghao Du Jie Du Qian Ren Source Type: research
The truncated MyD88s negatively regulates TLR2 signal on expression of IL17-1 in oyster Crassostrea gigas
Dev Comp Immunol. 2022 May 12:104446. doi: 10.1016/j.dci.2022.104446. Online ahead of print.ABSTRACTToll like receptor (TLR) signaling plays a key role in the innate immune recognition and inflammatory regulation in both vertebrates and invertebrates. The expanded TLR signaling components, including 83 TLRs and 10 MyD88s, have been reported in the genome of the Pacific oyster Crassostrea gigas. In the present study, one endogenous TLR (designated CgTLR2) and two MyD88s (including a full-length CgMyD88-2 containing intact TIR domain and Death-domain, and a truncated CgMyD88s with only TIR domain) were identified from oyster...
Source: Developmental and Comparative Immunology - May 15, 2022 Category: Allergy & Immunology Authors: Siqi Fan Weilin Wang Jialuo Li Wanqing Cao Qing Li Shasha Wu Lingling Wang Linsheng Song Source Type: research
Tetrandrine, an immunosuppressive alkaloid isolated from Steohania tetrandra S. Moore, induces the generation of Treg cells through enhancing fatty acid oxidation
CONCLUSION: The findings indicate that tetrandrine promotes Treg cell differentiation by enhancing FAO-mediated Foxp3 acetylation, and the CPT1-mediated FAO can serve as the target for the discovery of novel inducers of Treg cell generation. This article is protected by copyright. All rights reserved.PMID:35569103 | DOI:10.1111/imm.13500
Source: Immunology - May 15, 2022 Category: Allergy & Immunology Authors: Yulai Fang Qin Zhang Xusheng Yuan Changjun Lv Jing Zhang Yanrong Zhu Zhifeng Wei Yufeng Xia Yue Dai Source Type: research
The truncated MyD88s negatively regulates TLR2 signal on expression of IL17-1 in oyster Crassostrea gigas
Dev Comp Immunol. 2022 May 12:104446. doi: 10.1016/j.dci.2022.104446. Online ahead of print.ABSTRACTToll like receptor (TLR) signaling plays a key role in the innate immune recognition and inflammatory regulation in both vertebrates and invertebrates. The expanded TLR signaling components, including 83 TLRs and 10 MyD88s, have been reported in the genome of the Pacific oyster Crassostrea gigas. In the present study, one endogenous TLR (designated CgTLR2) and two MyD88s (including a full-length CgMyD88-2 containing intact TIR domain and Death-domain, and a truncated CgMyD88s with only TIR domain) were identified from oyster...
Source: Developmental and Comparative Immunology - May 15, 2022 Category: Allergy & Immunology Authors: Siqi Fan Weilin Wang Jialuo Li Wanqing Cao Qing Li Shasha Wu Lingling Wang Linsheng Song Source Type: research
