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Total 442 results found since Jan 2013.

LncRNA AK094457 promotes AngII-mediated hypertension and endothelial dysfunction through suppressing of activation of PPARγ
In conclusion, lncRNA AK094457 is identified as a key regulator in blood pressure and endothelial function, which can increase AngII-induced hypertension and endothelial dysfunction via suppression of PPARγ.
Source: Life Sciences - August 14, 2019 Category: Biology Source Type: research

Oxidized base 8-oxoguanine, a product of DNA repair processes, contributes to dendritic cell activation.
Abstract A growing body of evidence suggests that elevated levels of reactive oxygen species (ROS) in the airways caused by exposure to gas phase pollutants or particulate matter are able to activate dendritic cells (DCs); however, the exact mechanisms are still unclear. When present in excess, ROS can modify macromolecules including DNA. One of the most abundant DNA base lesions is 7,8-dihydro-8-oxoguanine (8-oxoG), which is repaired by the 8-oxoguanine DNA glycosylase 1 (OGG1)-initiated base excision repair (BER) pathway. Studies have also demonstrated that in addition to its role in repairing oxidized purines, ...
Source: Free Radical Biology and Medicine - August 9, 2019 Category: Biology Authors: Pázmándi K, Sütő M, Fekete T, Varga A, Boldizsár E, Boldogh I, Bácsi A Tags: Free Radic Biol Med Source Type: research

The first cloned echinoderm tumor necrosis factor receptor from Holothuria leucospilota: Molecular characterization and functional analysis
This study provides evidences for the potential roles of sea cucumber TNFR in the innate immunity.
Source: Fish and Shellfish Immunology - August 8, 2019 Category: Biology Source Type: research

Molecular cloning of Y-Box binding protein-1 from mandarin fish and its roles in stress-response and antiviral immunity
Publication date: October 2019Source: Fish & Shellfish Immunology, Volume 93Author(s): Jian He, Tao-Lin Xie, Xiao Li, Yang Yu, Zhi-Peng Zhan, Shao-Ping Weng, Chang-Jun Guo, Jian-Guo HeAbstractMandarin fish (Siniperca chuatsi) is a universally farmed fish species in China and has a large farming scale and economic value. With the high-density cultural mode in mandarin fish, viral diseases, such as infectious spleen and kidney necrosis virus (ISKNV) and Siniperca chuatsi rhabdovirus (SCRV), have increased loss, which has seriously restricted the development of aquaculture. Y-Box binding protein 1 (YB-1) is a member of cold s...
Source: Fish and Shellfish Immunology - August 3, 2019 Category: Biology Source Type: research

Berberine induces ZIP14 expression and modulates zinc redistribution to protect intestinal mucosal barrier during polymicrobial sepsis
Publication date: 15 September 2019Source: Life Sciences, Volume 233Author(s): Yan He, Xiaoming Yuan, Hao Zuo, Xiangwei Li, Ying Sun, Aiwen FengAbstractAimsThe present study investigated if berberine might induce Zrt-Irt-like protein 14 (ZIP14) and affect zinc redistribution to protect intestinal barrier in sepsis.Main methodsRodent model of sepsis was induced by cecal ligation and puncture (CLP). Plasma endotoxin was assayed by LAL test and plasma zinc was measured by flame atomic spectrophotometer. Gut mucosal permeability was determined by plasma FITC-dextran. Zinc content and ZIP14 mRNA in gut mucosa were assayed by sp...
Source: Life Sciences - July 31, 2019 Category: Biology Source Type: research

Litopenaeus vannamei Src64B restricts white spot syndrome virus replication by modulating apoptosis
In conclusion, the current data strongly suggest that Src64B is a host factor that inhibits WSSV replication by modulating apoptosis in shrimp.
Source: Fish and Shellfish Immunology - July 28, 2019 Category: Biology Source Type: research

Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury.
Conclusions: TL potentiate ROS by mitochondria which activate mitochondrial oxidative stress, decrease ATP production, increase mitochondrial proton leak and glycolysis rate, and mitochondria DNA damage. Additionally, CPT1A1 siRNA knockdown suppresses oxidative stress and prevents mitochondrial dysfunction and vascular inflammation in TL treated HBMECs. TL activates ATF3-MAPKinase, TNF, and NRF2 signaling pathways. Furthermore, the NRF2 signaling pathway which is upstream of the ATF3-MAPKinase signaling pathway, is also regulated by the mitochondrial oxidative stress. We are the first to report differential inflammatory ch...
Source: Free Radical Biology and Medicine - July 25, 2019 Category: Biology Authors: Nyunt T, Britton M, Wanichthanarak K, Budamagunta M, Voss JC, Wilson DW, Rutledge JC, Aung HH Tags: Free Radic Biol Med Source Type: research

The effects of Tel2 on cardiomyocyte survival
Publication date: 1 September 2019Source: Life Sciences, Volume 232Author(s): Naaiko Yorichika, Yuichi Baba, Briana K. Shimada, Manoj Thakore, Sharon M. Wong, Motoi Kobayashi, Jason K. Higa, Takashi MatsuiAbstractAimsOverexpression of the mechanistic target of rapamycin (mTOR), a member of the PIKK (phosphoinositide kinase-related kinase) family, protects cardiomyocytes from cell death induced by pathological stimuli such as ischemia. We previously reported that posttranslational modification of mTOR plays an important role in regulating cardiac mTOR expression. The aim of this study was to see if Tel2 (telomere maintenanc...
Source: Life Sciences - July 25, 2019 Category: Biology Source Type: research

S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2.
This study provides insights on the potential of CySSPe as an onion-derived dietary agent that modulates redox homeostasis and combats oxidative stress. PMID: 31349040 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - July 22, 2019 Category: Biology Authors: Tocmo R, Parkin K Tags: Free Radic Biol Med Source Type: research

MicroRNA-92b-3p suppresses angiotensin II-induced cardiomyocyte hypertrophy via targeting HAND2
In this study, we want to investigate the role of microRNA-92b-3p (miR-92b-3p) in cardiomyocyte hypertrophy and the mechanisms involved.Materials and methodsNeonatal mouse ventricular cells (NMVCs) were isolated from the hearts of 1–3-d-old newborn C57BL6 mice. The isolated NMVCs were induced hypertrophic phenotype by Angiotensin-II (Ang-II) and the cell size was examined by FITC-phalloidin staining assay. The expression of miR-92b-3p was determined by quantitative real-time PCR (qRT-qPCR). MRNA and protein level of β-MHC, ACTA1 and HAND2 in NMVCs transfected with miR-92b-3p mimic and inhibition were assessed by RT-qPCR...
Source: Life Sciences - July 6, 2019 Category: Biology Source Type: research

Calpain silencing alleviates myocardial ischemia-reperfusion injury through the NLRP3/ASC/Caspase-1 axis in mice
Publication date: Available online 3 July 2019Source: Life SciencesAuthor(s): Rong-Chuan Yue, Sheng-Zhong Lu, Yu Luo, Tao Wang, Hao Liang, Jing Zeng, Jie Liu, Hou-Xiang HuAbstractAimsPrior to reperfusion, Calpains remain inactive due to the acidic pH and elevated ionic strength in the ischemic myocardium; but Calpain is activated during myocardial reperfusion. The underlying mechanism of Calpain activation in the ischemia-reperfusion (I/R) is yet to be determined. Therefore, the present study aims to investigate the mechanism of Calpain in I/R-induced mice.Main methodsIn order to detect the function of Calpain and the NLRP...
Source: Life Sciences - July 4, 2019 Category: Biology Source Type: research

Elevated expression of hypoxia-inducible factor-2alpha regulated catabolic factors during intervertebral disc degeneration
Publication date: Available online 26 June 2019Source: Life SciencesAuthor(s): Yuelong Huang, Ying Wang, Chengai Wu, Wei TianAbstractHeadings aimsThe present study determined whether nucleus pulposus (NP) cells express hypoxia-inducible factor-2alpha (HIF-2α) and assessed its role in regulating the expression of catabolic factors during intervertebral disc degeneration.Materials and methodsHuman degenerated NP tissues were acquired to examine the HIF-2α expression levels using immunohistochemistry, western blotting, and Real-time PCR. Human NP cells were cultivated under normoxic or hypoxic conditions, and the HIF-2α ex...
Source: Life Sciences - June 26, 2019 Category: Biology Source Type: research

Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis
ConclusionHispidulin is a neuroprotective agent with clinical potential against IR-induced neurological injury.
Source: Life Sciences - June 25, 2019 Category: Biology Source Type: research

BmSd gene regulates the silkworm wing size by affecting the Hippo pathway
This article is protected by copyright. All rights reserved
Source: Insect Science - June 20, 2019 Category: Biology Authors: Jin Yin, Jing Zhang, Tao Li, Xia Sun, Sheng Qin, Cheng ‐Xiang Hou, Guo‐Zheng Zhang, Mu‐Wang Li Tags: ORIGINAL ARTICLE Source Type: research

Role of PGRMC1 in cell physiology of cervical cancer
In this study, we performed 2D-DIGE and MALDI-TOF/TOF MS to analyze differentially expressed proteins between HeLa and invasive HeLa-I5 cells..Key findingsAccording to our proteomics data, 68 differentially expressed proteins between the HeLa and HeLa-I5 cells were identified. One of these differentially expressed proteins, Progesterone receptor membrane component 1 (PGRMC1), was selected as a candidate for further studies. To correlate the role of PGRMC1 with cellular migration and cancer progression, small interfering RNA (siRNA) was used to knockdown the expression of PGRMC1. Similar function of PGRMC1 was also observed...
Source: Life Sciences - June 18, 2019 Category: Biology Source Type: research