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Endoscopic Study of the Distribution of Olfactory Filaments: A Cadaveric Study.
Abstract OBJECTIVE: Provide a detailed anatomical description of the olfactory filaments (OF) and their distribution in the nasal cavity through endoscopic endonasal dissection. METHODS: Four cadaveric specimens (8 sides) were used in this study. Nasoseptal (NSM), middle (MTM) and superior turbinate (STM) mucosa dissection was performed to identify the OF and follow them superiorly to the cribriform plate (CP). Measurements of the OF were taken on the NSM, MTM, STM under direct endoscopic visualization. A Student's T-Test was performed to compare means. RESULTS: The NSM contained a mean of 11 OF, distrib...
Source: American Journal of Rhinology and Allergy - August 5, 2020 Category: ENT & OMF Authors: Soriano RM, Arturo Solares C, Pradilla G, DelGaudio JM Tags: Am J Rhinol Allergy Source Type: research

PARP-14 Promotes Survival of Mammalian α but Not β Pancreatic Cells Following Cytokine Treatment
Conclusion This study must be seen as a first piece of a puzzle where PARP-14, JNKs and PJ-34 play key roles in the pancreatic microenvironment and provide starting points from which to explore further. Author Contributions VS-P conceived the project and designed the experiments together with MP and CD. MR and FD performed molecular experiments as RT-PCR and western analysis. CS and MS performed confocal analysis. FD, NM, and VB performed cytofluorimetric analysis. FD and MC were in charge of cell culture and treatment. FD performed computational and statistical data analysis, together with AT-S. VS-P and FD wrote the p...
Source: Frontiers in Endocrinology - May 2, 2019 Category: Endocrinology Source Type: research

Systems Biology Analysis of the Effect and Mechanism of Qi-Jing-Sheng-Bai Granule on Leucopenia in Mice
Conclusion In summary, our data reveal the therapeutic mechanism of QJSB by integrative application of transcriptomics-based network pharmacology and metabolomics technologies. QJSB exerts protective effect against leucopenia in mice through participating in multi-pathways, mainly including accelerating cell proliferation and differentiation, regulating metabolism response pathways and modulating immunologic function. Ethics Statement All animal studies were performed according to the institutional ethical guidelines of animal care and were approved by the Committee on the Ethics of Animal Experiments of the Second Mili...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice
Conclusion: Our data suggest that mirtazapine can attenuate hepatic innate immune responses that critically regulate the subsequent development of autoimmune liver injury. Therefore, given that it is a safe and widely used medication, mirtazapine may represent a novel therapeutic approach to autoimmune liver disease. Introduction Classically, autoimmune disease was considered a disorder of adaptive immunity (1). However, early innate immune responses are clearly important for driving subsequent adaptive immune responses in autoimmunity. In numerous autoimmune disease models, activation of resident tissue macrophages,...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

NIH launches 3D Print Exchange
The National Institutes of Health (NIH) recently launched the NIH 3D Print Exchange, a public website that enables users to share, download, and edit 3D print files related to health and science. These files can be used, for example, to print custom laboratory equipment and models of bacteria and human anatomy. The NIH 3D Print Exchange also provides video tutorials and additional resources with instruction on 3D modeling software to enable users to customize and create 3D prints. “3D printing is a potential game changer for medical research,” said NIH Director Francis S. Collins, M.D., Ph.D. “At NIH, we have seen an...
Source: Network News - June 24, 2014 Category: Databases & Libraries Authors: Emily Hurst Tags: General (all entries) Technology 3d 3d printing NIH open data open science Source Type: news