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UCLA-led team gets $8.4 million NIH grant to probe mysteries of Valley Fever
Why do some people infected with Valley Fever develop a potentially fatal form of the disease that ravages their body while most experience only mild symptoms or none at all?A team led by UCLA ’s Dr. Manish Butte has been awarded an $8.4 million grant from the National Institute of Allergy and Infectious Diseases to study this and other questions related to genetic risk factors and immune responses to the disease, which occurs when people breathe in microscopic spores of the fungusCoccidioides that are present in soil.First identified in Argentina in the late 1800s, Valley Fever today is seen in a geographic swath that s...
Source: UCLA Newsroom: Health Sciences - February 15, 2022 Category: Universities & Medical Training Source Type: news

Study vaccine protects monkeys against four types of hemorrhagic fever viruses
(NIH/National Institute of Allergy and Infectious Diseases) Scientists funded by the National Institutes of Health have developed an investigational vaccine that protected cynomolgus macaques against four types of hemorrhagic fever viruses endemic to overlapping regions in Africa. The University of Texas Medical Branch in Galveston and Profectus BioSciences of New York are developing and testing the candidate quadrivalent VesiculoVax vaccine, with support from NIH's National Institute of Allergy and Infectious Diseases (NIAID) and Redeemer's University in Nigeria.
Source: EurekAlert! - Infectious and Emerging Diseases - November 8, 2019 Category: Infectious Diseases Source Type: news

Surface (S) Layer Proteins of Lactobacillus acidophilus Block Virus Infection via DC-SIGN Interaction
We describe the unexpected binding of S-layer to cells devoid of DC-SIGN but also confirm that the presence of DC-SIGN was essential for S-layer’s antiviral activity. S-layer protein exerted its antiviral effect with different kinetics than mannan, a known viral inhibitor that also acts on DC-SIGN (Yu et al., 2017). Together our results suggest that inhibition of viral entry by S-layer occurs via a novel S-layer/DC-SIGN interaction. Materials and Methods Isolation of S-Layer Proteins S-layer proteins were extracted from overnight cultures of L. acidophilus ATCC 4356 cells grown in MRS medium at 37°C by usi...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

5 Ways The Zika Virus Is Here To Stay
Zika virus’ status as a global health threat may officially be over, but the disease’s impact is far from contained.  The World Health Organization decided in November to end its designation of Zika virus as a public health emergency, but that doesn’t mean that Zika virus has disappeared, explained Dr. Carlos Pardo-Villamizar, a clinical neurologist with an expertise in infectious disorders at Johns Hopkins Medicine. Alongside pressing concerns about how to prevent a resurgence of the disease, health care systems in Brazil and other countries that saw births of babies infected with the disease in ute...
Source: Science - The Huffington Post - January 4, 2017 Category: Science Source Type: news