Filtered By:
Drug: Insulin
This page shows you your search results in order of date.
Order by Relevance | Date
Total 1048 results found since Jan 2013.
GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis
ConclusionsGCH1 inhibited ferroptosis in LPS-stimulated macrophages, reduced macrophage toward to M1 polarization and inflammatory response.
Source: Inflammation Research - September 21, 2023 Category: Research Source Type: research
Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia
Neurochem Res. 2023 Sep 13. doi: 10.1007/s11064-023-04022-7. Online ahead of print.ABSTRACTActivation of glial cells, astrocytes and microglia, has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Amyloid β (Aβ), which is aggregated and the aggregation is detected as characteristic pathology in AD brain, is known to be produced by neurons and to activate glial cells. Clearance of Aβ from the brain via active transport system is important to prevent the accumulation and aggregation. Low density lipoprotein receptor-related protein 2 (LRP2/megalin) is an Aβ transporter. However, expression ...
Source: Neurochemical Research - September 13, 2023 Category: Neuroscience Authors: Katsura Takano-Kawabe Kazuyuki Matoba Yoichi Nakamura Mitsuaki Moriyama Source Type: research
Spexin role in human granulosa cells physiology and PCOS: expression and negative impact on steroidogenesis and proliferation
Biol Reprod. 2023 Sep 2:ioad108. doi: 10.1093/biolre/ioad108. Online ahead of print.ABSTRACTSpexin (SPX) is a novel neuropeptide and adipokine negatively correlated with obesity and insulin resistance. A recent study investigated expression and regulatory function of SPX in the hypothalamus and pituitary; however, the effect on ovarian function is still unknown. The aim of this study was to characterize the expression of SPX and its receptors, galanin receptors 2 and 3 (GALR2/3) in the human ovary and to study its in vitro effect on granulosa cells (GC) function. Follicular fluid (FF) and GC were obtained from normal weigh...
Source: Reproductive Biology - September 2, 2023 Category: Reproduction Medicine Authors: Patrycja Kurowska Monika Dawid Julia Oprocha Natalia Repekta Lo ïse Serra Anthony Estienne Piotr Pawlicki Ma łgorzata Kotula-Balak Fabrice Gu érif Joelle Dupont Agnieszka Rak Source Type: research
Role of < em > Dgat2 < /em > in Glucose Uptake and Fatty Acid Metabolism in C2C12 Skeletal Myotubes
J Microbiol Biotechnol. 2023 Aug 18;33(12):1-9. doi: 10.4014/jmb.2307.07018. Online ahead of print.ABSTRACTAcyl-coenzyme A (CoA):diacylglycerol acyltransferase 2 (DGAT2) catalyzes the last stage of triacylglycerol (TAG) synthesis, a process that forms ester bonds with diacylglycerols (DAG) and fatty acyl-CoA substrates. The enzymatic role of Dgat2 has been studied in various biological species. Still, the full description of how Dgat2 channels fatty acids in skeletal myocytes and the consequence thereof in glucose uptake have yet to be well established. Therefore, this study explored the mediating role of Dgat2 in glucose ...
Source: Journal of Microbiology and Biotechnology - August 30, 2023 Category: Biotechnology Authors: So Young Bu Source Type: research
Resveratrol improves palmitic acid ‑induced insulin resistance via the DDIT4/mTOR pathway in C2C12 cells
In conclusion, RSV may improve PA‑induced IR in C2C12 cells through the DDIT4/mTOR/IRS‑1/PI3K/AKT/GLUT4 signaling pathway, as well as via improvements in glucose and lipid metabolism.PMID:37594055 | DOI:10.3892/mmr.2023.13068
Source: Molecular Medicine Reports - August 18, 2023 Category: Molecular Biology Authors: Xinyan Pan Chunqiao Liu Xing Wang Ming Zhao Zhimei Zhang Xuemei Zhang Chao Wang Guangyao Song Source Type: research
