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Drug: Insulin

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Total 83 results found since Jan 2013.

Comprehensive Carrier Screening and Molecular Diagnostic Testing for Recessive Childhood Diseases
Clinical Scenarios The test is designed both for preconception carrier testing of couples wishing to start a family and for molecular diagnosis in children suspected of being affected by a recessive childhood disease. The published (research) version of the test included 448 childhood recessive illnesses with severe clinical manifestations1. A revised panel is undergoing clinical validation for use as a laboratory developed test (LDT) with an intention of being offered via a laboratory regulated by the Clinical Laboratory Improvement Amendments (CLIA). The clinical panel contains 595 childhood recessive diseases that are d...
Source: PLOS Currents Evidence on Genomic Tests - May 2, 2012 Category: Genetics & Stem Cells Authors: stephenkingsmore Source Type: research

Effects of high-intensity interval training (HIIT) on skeletal muscle atrophy, function, and myokine profile in diabetic myopathy
CONCLUSION: Current findings show that diabetic myopathy develops earlier in glycolytic-fast-twitch fibers(EDL) than in oxidative-slow-twitch fibers(soleus). Furthermore, HIIT application prevents atrophy in skeletal muscle, increases resistance to fatigue, and has an anti-inflammatory effect.NEW FINDINGS: The current study analyzes the myokine profile and skeletal muscle function under the effect of diabetes HIIT-type exercise. We also measured maximal exercise capacity and tailored the exercise program individually according to the result. Diabetic myopathy is an important complication of diabetes yet still, it is not un...
Source: Cytokine - June 17, 2023 Category: Molecular Biology Authors: Ye şim Özçatal F ırat Akat Yakup Tatar Hakan F ıçıcılar Bilge Serdaro ğlu Ferda Topal Çelikkan Metin Ba ştuğ Source Type: research

Diabetic Myopathy: current molecular understanding of this novel neuromuscular disorder
Purpose of review: Here we summarize the evidence from human studies of the impairments to the structural, functional, and metabolic capacities in skeletal muscle in those with type 1 diabetes (T1D) – a condition known as diabetic myopathy. Given the importance of skeletal muscle for blood lipid and glucose management, the development and progression of diabetic myopathy would not only lead to increased insulin resistance, but also impact the ability to mitigate dysglycemic/dyslipidemic burdens. Recent findings: Despite the importance of skeletal muscle in whole-body metabolic control, studies investigating diabetic myo...
Source: Current Opinion in Neurology - September 1, 2017 Category: Neurology Tags: NEUROMUSCULAR DISEASE: MUSCLE: Edited by Benedikt Schoser Source Type: research

Novel PTRF mutation in a child with mild myopathy and very mild congenital lipodystrophy
Conclusions: The PTRF gene should be investigated in patients with hyperCKemia, mild myopathy associated with spontaneous or percussion-induced muscle contractions like rippling or mounding, and no CAV3 mutation. The analysis should be performed even if cardiac or metabolic alterations are absent, particularly in young patients in whom lipodystrophy may be difficult to ascertain.
Source: BMC Medical Genetics - Latest articles - September 11, 2013 Category: Genetics & Stem Cells Authors: Anna ArdissoneCinzia BragatoLorella CaffiFlavia BlasevichSabrina MaestriniMaria BianchiLucia MorandiIsabella MoroniMarina Mora Source Type: research

Metabolic Consequences of Adipose Trigliceride Lipase Deficiency in Humans: An In Vivo Study in Patients with Neutral Lipid Storage Disease with Myopathy.
Conclusions.In humans ATGL has a remarkable effect on cellular lipid droplets handling and its lack causes both peri-visceral, skeletal muscle and pancreas fat accumulation; in contrast, the impact on whole body insulin sensitivity and fatty acid metabolism is minor. PMID: 23824421 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - July 3, 2013 Category: Endocrinology Authors: Natali A, Gastaldelli A, Camastra S, Baldi S, Quagliarini F, Minicocci I, Bruno C, Pennisi E, Arca M Tags: J Clin Endocrinol Metab Source Type: research

Interventions for preventing critical illness polyneuropathy and critical illness myopathy.
CONCLUSIONS: There is moderate quality evidence from two large trials that intensive insulin therapy reduces CIP/CIM, and high quality evidence that it reduces duration of mechanical ventilation, ICU stay and 180-day mortality, at the expense of hypoglycaemia. Consequences and prevention of hypoglycaemia need further study. There is moderate quality evidence which suggests no effect of corticosteroids on CIP/CIM and high quality evidence that steroids do not affect secondary outcomes, except for fewer new shock episodes. Moderate quality evidence suggests a potential benefit of early rehabilitation on CIP/CIM which is acc...
Source: Cochrane Database of Systematic Reviews - February 3, 2014 Category: Journals (General) Authors: Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G Tags: Cochrane Database Syst Rev Source Type: research

Insulin resistance and increased muscle cytokine levels in patients with mitochondrial myopathy.
Conclusions: In patients with a variety of mitochondrial myopathies, insulin sensitivity of muscle, adipose tissue and pancreatic A cells is reduced, supporting that mitochondrial function influences insulin action. Furthermore, a local, low-grade inflammation of potential clinical importance exists in muscle of these patients. PMID: 25057876 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - July 24, 2014 Category: Endocrinology Authors: Rue N, Vissing J, Galbo H Tags: J Clin Endocrinol Metab Source Type: research

Diabetes in the young - a case of Alström syndrome with myopathy.
In this report, we describe a patient with features of Alström syndrome and a clinical picture suggestive of a recurrent, severe, steroid responsive myopathy which, to the best of our knowledge, has not been reported so far. PMID: 25874828 [PubMed - in process]
Source: Journal of the Royal College of Physicians of Edinburgh - November 30, 2015 Category: Journals (General) Tags: J R Coll Physicians Edinb Source Type: research

Early Onset of Diabetes Mellitus Accelerates Cognitive Decline in Japanese Patients with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes.
Abstract Approximately 80% of patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) carry the A3243G mutation in the mitochondrial tRNALeu (UUR) gene. Conversely, this mutation has also been identified as one of the most prevalent genetic abnormalities in patients with diabetes mellitus. Mitochondrial diabetes mellitus complicated with MELAS is relatively common, and 12.5% of patients with the A3243G mutation develop MELAS after being diagnosed with diabetes mellitus. However, the clinical impact of diabetes mellitus in MELAS patients remains unclear. Therefore, we...
Source: The Tohoku Journal of Experimental Medicine - April 13, 2016 Category: Research Authors: Murakami T, Shinoto Y, Yonemitsu S, Muro S, Oki S, Koga Y, Goto Y, Kaneda D Tags: Tohoku J Exp Med Source Type: research

Homozygous LIPE mutation in siblings with multiple symmetric lipomatosis, partial lipodystrophy, and myopathy
Despite considerable progress in identifying causal genes for lipodystrophy syndromes, the molecular basis of some peculiar adipose tissue disorders remains obscure. In an Israeli–Arab pedigree with a novel autosomal recessive, multiple symmetric lipomatosis (MSL), partial lipodystrophy and myopathy, we conducted exome sequencing of two affected siblings to identify the disease‐causing mutation. The 41‐year‐old female proband and her 36‐year‐old brother reported marked accumulation of subcutaneous fat in the face, neck, axillae, and trunk but loss of subcutaneous fat from the lower extremities and progressive d...
Source: American Journal of Medical Genetics Part A - November 10, 2016 Category: Genetics & Stem Cells Authors: Sagit Zolotov, Chao Xing, Riad Mahamid, Adel Shalata, Mohammed Sheikh ‐Ahmad, Abhimanyu Garg Tags: Clinical Report Source Type: research

Patients with low IGF-I after curative surgery for Cushing's syndrome have an adverse long-term outcome of hypercortisolism-induced myopathy
CONCLUSION: Lower individual IGF-I concentrations six months after curative surgery for Cushing's syndrome are associated with adverse long-term myopathy outcome and IGF-I might be essential for muscle regeneration in the early phase after correction of hypercortisolism.PMID:33830940 | DOI:10.1530/EJE-20-1285
Source: European Journal of Endocrinology - April 8, 2021 Category: Endocrinology Authors: Frederick Vogel Leah Braun German Rubinstein Stephanie Zopp Sarina Benedix Holger Schneider Katrin Ritzel Katharina Schilbach Ralf Schmidmaier Felix Beuschlein Martin Bidlingmaier Martin Reincke Source Type: research