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Risk of thromboembolism in patients with COVID-19 who are using hormonal contraception
CONCLUSIONS: There are no comparative studies assessing risk of thromboembolism in COVID-19 patients who use hormonal contraception, which was the primary objective of this review. Very little evidence exists examining the risk of increased COVID-19 disease severity for combined hormonal contraception users compared to non-users of hormonal contraception, and the evidence that does exist is of very low certainty. The odds of hospitalization for COVID-19 positive users of combined hormonal contraceptives may be slightly decreased compared with those of hormonal contraceptive non-users, but the evidence is very uncertain as ...
Source: Cochrane Database of Systematic Reviews - January 9, 2023 Category: General Medicine Authors: Megan A Cohen Alison Edelman Robin Paynter Jillian T Henderson Source Type: research

O-133 Effect of non-surgical treatments on the size of endometrioma: A systematic review and Meta-Analysis
ConclusionsMedical treatment from different groups significantly reduces the endometrioma size, and relives painful symptoms.Limitations, reasons for cautionDespite the nature of the randomized includedstudies, the results of this study are still subjected to confounders relating to clinical and statistical heterogeneity. the studies reported the outcomes differentlyWider implications of the findingsmedical treatment can be given the surgery can be avoided, therefore preserve the ovarian tissue. There is limited controlled study to examine the effectiveness of the treatment for endometrioma.Trial registration number–––––––––
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research

Risk of thromboembolism in patients with COVID-19 who are using hormonal contraception
CONCLUSIONS: There are no comparative studies assessing risk of thromboembolism in COVID-19 patients who use hormonal contraception, which was the primary objective of this review. Very little evidence exists examining the risk of increased COVID-19 disease severity for combined hormonal contraception users compared to non-users of hormonal contraception, and the evidence that does exist is of very low certainty. The odds of hospitalization for COVID-19 positive users of combined hormonal contraceptives may be slightly decreased compared with those of hormonal contraceptive non-users, but the evidence is very uncertain as ...
Source: Cochrane Database of Systematic Reviews - January 9, 2023 Category: General Medicine Authors: Megan A Cohen Alison Edelman Robin Paynter Jillian T Henderson Source Type: research

Unique expression of 35 KDa protein in serum and cystic fluid of women with malignant ovarian cysts substantiates its role in disease progression
Conclusions Taken together these data indicate a uniquely expressed protein of 35 kDa in patients with malignant ovarian cysts that may serve as a specific protein biomarker for the differential diagnosis of the ovarian cancer. However, a much larger sample of subjects is required to validate and confirm these findings.
Source: Asian Pacific Journal of Reproduction - August 7, 2015 Category: Reproduction Medicine Source Type: research

First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls
Conclusion: BPA may have toxic effects on the female reproductive system in humans, as it does in animal models. Higher first-trimester BPA exposure was associated with significantly shorter AGD in daughters, suggesting that BPA may alter the hormonal environment of the female fetus. https://doi.org/10.1289/EHP875 Received: 27 July 2016 Revised: 18 January 2017 Accepted: 19 January 2017 Published: 11 July 2017 Address correspondence to E. S. Barrett, Dept. of Epidemiology, Environmental and Occupational Health Sciences Institute, Rutgers University School of Public Health, 170 Frelinghuysen Road, Piscataway, NJ 08854...
Source: EHP Research - July 11, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Human Health Effects of Dichloromethane: Key Findings and Scientific Issues
Conclusion: The 2011 IRIS assessment of dichloromethane provides insights into the toxicity of a commonly used solvent. Citation: Schlosser PM, Bale AS, Gibbons CF, Wilkins A, Cooper GS. 2015. Human health effects of dichloromethane: key findings and scientific issues. Environ Health Perspect 123:114–119; http://dx.doi.org/10.1289/ehp.1308030 Address correspondence to G.S. Cooper, National Center for Environmental Assessment (8601-P), U.S. Environmental Protection Agency, 1200 Pennsylvania Ave. NW, Washington, DC 20460 USA. Telephone: (703) 347-8636. E-mail: Cooper.Glinda@epa.gov The views expressed are thos...
Source: EHP Research - February 2, 2015 Category: Environmental Health Authors: Web Admin Tags: Commentary February 2015 Source Type: research

Urinary Concentrations of Organophosphate Flame Retardant Metabolites and Pregnancy Outcomes among Women Undergoing in Vitro Fertilization
Conclusions: Using IVF to investigate human reproduction and pregnancy outcomes, we found that concentrations of some urinary PFR metabolites were negatively associated with proportions of successful fertilization, implantation, clinical pregnancy, and live birth. https://doi.org/10.1289/EHP1021 Received: 26 August 2016 Revised: 10 April 2017 Accepted: 02 June 2017 Published: 25 August 2017 Address correspondence to C. Carignan, Department of Environmental Health, Building 1, 14th Floor, 665 Huntington Avenue, Boston, MA 02115 USA. Phone: (617) 432-4572. Email: carignan@hsph.harvard.edu Supplemental Material is avail...
Source: EHP Research - August 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Identification of Substandard Medicines via Disproportionality Analysis of Individual Case Safety Reports
ConclusionThis study illustrates the value of data mining of spontaneous adverse event reports and the applicability of disproportionality analysis to identify potential SSMs.
Source: Drug Safety - January 27, 2017 Category: Drugs & Pharmacology Source Type: research

A Case –Control Study of Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Cryptorchidism in Canadian Populations
Conclusions: Our results suggest that maternal exposure to BDE-99, -100, and -154 may be associated with abnormal migration of testes in the male fetus. This may be due to the anti-androgenic properties of the PBDEs. https://doi.org/10.1289/EHP522 Received: 17 May 2016 Revised: 22 September 2016 Accepted: 08 October 2016 Published: 26 May 2017 Address correspondence to C.G. Goodyer, Research Institute of McGill University Health Centre, Centre for Translational Biology, EM0.3211, 1001 Decarie Blvd., Montreal, QC, Canada H4A 3J1. Telephone: (514) 934-1934, ext. 22481. E-mail: cindy.goodyer@muhc.mcgill.ca Supplemental Mat...
Source: EHP Research - May 27, 2017 Category: Environmental Health Authors: Terrie Young Tags: Research Source Type: research

Endocrine Disruptors and Health Effects in Africa: A Call for Action
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - August 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine-device use
CONCLUSIONS: Findings from this review should be interpreted with caution due to low- and very low-certainty evidence. Included trials were limited; the majority of the evidence was derived from single trials with few participants. Further research requires larger trials and improved trial reporting. The use of vitamin B1 and mefenamic acid to treat heavy menstruation and tolfenamic acid to prevent heavy menstruation associated with Cu IUD should be investigated. More trials are needed to generate evidence for the treatment and prevention of heavy and painful menstruation associated with LNG IUD.PMID:36017945 | PMC:PMC9413...
Source: Cochrane Database of Systematic Reviews - August 26, 2022 Category: General Medicine Authors: Karen Christelle Mohd N Norhayati Sharifah Halimah Jaafar Source Type: research