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Drug: Metformin
Nutrition: Carbohydrates
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Total 102 results found since Jan 2013.
ChREBP- β/TXNIP aggravates frucose-induced renal injury through triggering ferroptosis of renal tubular epithelial cells
In conclusion, ChREBP-β mediates fructose-induced ferroptosis of renal tubular epithelial cells, and metformin with a ChREBP-β inhibitory effect may be a potential treatment for ferroptosis of renal tubular epithelial cells.PMID:36828294 | DOI:10.1016/j.freeradbiomed.2023.02.013
Source: Free Radical Biology and Medicine - February 24, 2023 Category: Biology Authors: Hang Guo Ting Fang Ying Cheng Ting Li Jing-Ru Qu Chao-Fei Xu Xiao-Qing Deng Bei Sun Li-Ming Chen Source Type: research
Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: Inositol is an effective and safe treatment in PCOS. Moreover, inositols showed non-inferiority in most outcomes compared to the gold standard treatment; metformin.TRIAL REGISTRATION: PROSPERO registration number: CRD42021283275.PMID:36703143 | DOI:10.1186/s12958-023-01055-z
Source: Reproductive Biology - January 26, 2023 Category: Reproduction Medicine Authors: Dorina Greff Anna E Juh ász Szil árd Váncsa Alex V áradi Zolt án Sipos Julia Szinte Sunjune Park P éter Hegyi P éter Nyirády N ándor Ács Szabolcs V árbíró Eszter M Horv áth Source Type: research
Metformin modified chitosan as a multi-functional adjuvant to enhance cisplatin-based tumor chemotherapy efficacy
Int J Biol Macromol. 2022 Oct 22:S0141-8130(22)02409-6. doi: 10.1016/j.ijbiomac.2022.10.167. Online ahead of print.ABSTRACTRecently, it was newly revealed that the DNA damage induced by cis‑platinum (Cis-Pt) mediated chemotherapy was significantly impaired by the highly expressed programmed death ligand-1 (PD-L1) in tumor cells. Besides, the efficacy of Cis-Pt was also limited due to its severe side effects, especially enhanced drug efflux induced by multidrug resistance protein 1 (MDR-1) and increased tumor metastasis. Up to now, few drugs or carbohydrates could simultaneously solve these defects of Cis-Pt mediated chem...
Source: International Journal of Biological Macromolecules - October 25, 2022 Category: Biochemistry Authors: Zaigang Zhou Yu Liu Xin Jiang Chunjuan Zheng Wenjuan Luo Xinli Xiang Xiaoliang Qi Jianliang Shen Source Type: research
Onkodiabetol ógia II
Orv Hetil. 2022 Oct 2;163(40):1575-1584. doi: 10.1556/650.2022.32041. Print 2022 Oct 2.ABSTRACTThe number of patients with type 2 diabetes is increasing worldwide. In Hungary, the prevalence of known diabetic adults exceeds 9.1%, causing increased economical and medical burden to the society. It is obvious that there is a considerable urge to develop novel, safer and more efficient antidiabetic drugs. Therefore, studies have been focusing on the beneficial or detrimental side effects of antidiabetic drugs besides their general metabolic effects. Every antidiabetic agent has an indirect anti-tumor effect as a consequence of...
Source: Orvosi Hetilap - October 2, 2022 Category: General Medicine Authors: R óbert János Bánhegyi Andrea Gazdag Beatrix R ácz L ászló Szalai R óbert Wágner Norbert F ülöp Source Type: research
Diagnosis and management of hyperglycaemia in patients treated with antipsychotic drugs
Endokrynol Pol. 2022 Aug 16. doi: 10.5603/EP.a2022.0071. Online ahead of print.ABSTRACTResearch results indicate the presence of an association between mental disorders, certain antipsychotics, and the risk of developing prediabetes (preDM) and specific type diabetes mellitus (DM). However, there are no precise recommendations for their diagnosis and treatment. The obtained data suggest the necessity to perform diagnostics of carbohydrate disorders at the onset of the first symptoms of psychosis, even before the implementation of antipsychotic drugs, and the oral glucose tolerance test (OGTT) seems to be the optimal tool. ...
Source: Endokrynologia Polska - August 16, 2022 Category: Endocrinology Authors: Marcin Kosmalski Monika R óżycka-Kosmalska Marcin Basiak Bogus ław Okopień Tadeusz Pietras Source Type: research
