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Upregulation of Airway Smooth Muscle Calcium-Sensing Receptor by Low Molecular Weight Hyaluronan.
Abstract We investigated the mechanisms involved in the development of airway hyperresponsiveness (AHR) in mice following exposure to halogens. Male mice (C57BL/6; 20-25 g) exposed to either bromine (Br2) or Cl2 (600 or 400 ppm, respectively, for 30 min) developed AHR 24 hours post exposure. Nifedipine (an L-type calcium channel blocker) administered subcutaneously post Br2 or Cl2 exposure (5 mg/kg BW), resulted in higher AHR compared to Br2 or Cl2 alone. In contrast, diltiazem (a non-dihydropyridine L-type calcium channel blocker) decreased AHR to control (air) values. Exposure of immortalized human airway smooth...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - January 7, 2020 Category: Cytology Authors: Lazrak A, Yu Z, Doran S, Jian M, Creighton J, Laube M, Garantziotis S, Prakash YS, Matalon S Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Coagulation factor XI induces Ca2+ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1.
In conclusion, FXIa mainly elicits Ca2+ signal via the PAR1/CaV1.2-mediated Ca2+ influx and accelerates the migration in vascular smooth muscle cells. The present study provides the first evidence that FXIa exerts a direct cellular effect on vascular smooth muscle. PMID: 30566391 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - December 19, 2018 Category: Cytology Authors: Liu W, Hashimoto T, Yamashita T, Hirano K Tags: Am J Physiol Cell Physiol Source Type: research

AMP-activated protein kinase is involved in perfluorohexanesulfonate -induced apoptosis of neuronal cells.
Abstract Perfluorohexanesulfonate (PFHxS), one of the major perfluoroalkyl compounds (PFCs), has been used in a variety of industrial and consumer applications and detected in serum in the general population. This raised a concern over its possible detrimental health effects, including neurotoxic effects. We have previously shown that PFHxS induced neuronal apoptosis via the NMDA receptor-mediated extracellular signal-regulated kinase (ERK) pathway. Recently, it has been reported that AMP-activated protein kinase (AMPK) acts as a key signal molecule in neuronal excitotoxicity as well as providing a neuroprotective...
Source: Chemosphere - January 27, 2016 Category: Chemistry Authors: Lee YJ, Choi SY, Yang JH Tags: Chemosphere Source Type: research

Homer proteins mediate the interaction between STIM1 and Cav1.2 channels
Publication date: Available online 21 February 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Natalia Dionisio , Tarik Smani , Geoffrey E. Woodard , Antonio Castellano , Gines M. Salido , Juan A. Rosado STIM1 is an ubiquitous Ca2+ sensor of the intracellular, agonist-sensitive, Ca2+ stores that communicates the filling state of the Ca2+ compartments to plasma membrane store-operated Ca2+ (SOC) channels. STIM1 has been presented as a point of convergence between store-operated and voltage-operated Ca2+ influx, both inducing activation of SOC channels while suppressing Cav1.2 channels....
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - February 22, 2015 Category: Molecular Biology Source Type: research

Dihydropyridine Ca2+ Channel Blockers Increase Cytosolic Ca2+ by Activating Ca2+-sensing Receptors in Pulmonary Arterial Smooth Muscle Cells.
Conclusions: The dihydropyridine derivatives increase [Ca(2+)](cyt) by potentiating the activity of CaSR in PASMC independently of their blocking (or activating) effect on Ca(2+) channels; therefore, it is possible that use the dihydropyridine Ca(2+) channel blockers (e.g., nifedipine) to treat IPAH patients with upregulated CaSR in PASMC may exacerbate pulmonary hypertension. PMID: 23300272 [PubMed - as supplied by publisher]
Source: Circulation Research - January 8, 2013 Category: Cardiology Authors: Yamamura A, Yamamura H, Guo Q, Zimnicka AM, Wang J, Ko EA, Smith KA, Pohl NM, Song S, Zeifman A, Makino A, Yuan JX Tags: Circ Res Source Type: research