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Folate appended cyclodextrins for drug, DNA, and siRNA delivery.
Abstract Drug, DNA, and siRNA delivery systems based on cyclodextrin (CD) core and connected with folate (FA) via various linkers are presented. They include simple mono-derivatized cyclodextrins as well as cyclodextrins with higher degree of substitution, both in their primary and secondary sides. Examples of simple polymers and dendrimers are also discussed. Such carriers possess properties inherent to both of their components. Cyclodextrin provides the ability to encapsulate organic molecules in its inner cavity, thus improving their solubility in water, bioavailability, and stability, while FA assures targetin...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 9, 2017 Category: Drugs & Pharmacology Authors: Ceborska M Tags: Eur J Pharm Biopharm Source Type: research

Bone-targeted nanoplatform enables efficient modulation of bone tumor microenvironment for prostate cancer bone metastasis treatment
Drug Deliv. 2022 Dec;29(1):889-905. doi: 10.1080/10717544.2022.2050845.ABSTRACTAs there is currently no effective therapy for patients with prostate cancer (PCa) bone metastasis, it was stringent to explore the relevant treatment strategies. Actually, the interaction between cancer cells and bone microenvironment plays important role in prostate cancer bone metastasis, especially the Sonic hedgehog protein (SHH) signaling in the bone microenvironment. The SHH promotes osteoblast maturation and osteoblast then secretes RANKL to induce osteoclastogenesis. Herein, this study develops bone-targeting calcium phosphate lipid hyb...
Source: Drug Delivery - March 14, 2022 Category: Drugs & Pharmacology Authors: Xiangyu Zhang Qingbin Liu Tingting Zhang Pei Gao Hui Wang Lu Yao Jingwen Huang Shulong Jiang Source Type: research

Dual function of programmed cell death 10 (PDCD10) in drug resistance
Publication date: May 2018 Source:Biomedicine & Pharmacotherapy, Volume 101 Author(s): Cagri Urfali-Mamatoglu, Hasan Hüseyin Kazan, Ufuk Gündüz Drug resistance, a major challenge in cancer chemotherapy, is a result of several mechanistic alterations including resistance to apoptosis. Apoptosis is a well-controlled cell death mechanism which is regulated by several signaling pathways. Alterations in structure, function, and expression pattern of the proteins involved in the regulation of apoptosis have been linked to drug resistance. Programmed Cell Death 10 (PDCD10) protein is recently associated with the regul...
Source: Biomedicine and Pharmacotherapy - February 24, 2018 Category: Drugs & Pharmacology Source Type: research

Dual function of programmed cell death 10 (PDCD10) in drug resistance.
Abstract Drug resistance, a major challenge in cancer chemotherapy, is a result of several mechanistic alterations including resistance to apoptosis. Apoptosis is a well-controlled cell death mechanism which is regulated by several signaling pathways. Alterations in structure, function, and expression pattern of the proteins involved in the regulation of apoptosis have been linked to drug resistance. Programmed Cell Death 10 (PDCD10) protein is recently associated with the regulation of cell survival and apoptosis. However, the role of PDCD10 in drug resistance has not been clearly established. Here, we aimed to f...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 23, 2018 Category: Drugs & Pharmacology Authors: Urfali-Mamatoglu C, Kazan HH, Gündüz U Tags: Biomed Pharmacother Source Type: research

Midkine silencing enhances the anti –prostate cancer stem cell activity of the flavone apigenin: cooperation on signaling pathways regulated by ERK, p38, PTEN, PARP, and NF-κB
In conclusion, MK-regulated events are different between PCSCs, and when combined with apigenin plus MK silencing, docetaxel treatment may be a valuable approach for the eradication of PCSCs.
Source: Investigational New Drugs - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Upregulation of GRIM-19 augments the sensitivity of prostate cancer cells to docetaxel by targeting Rad23b.
This study aims to clarify the potential role and molecular mechanisms of GRIM-19 on the response of PC cells to chemical drug docetaxel. mRNA and protein level of GRIM-19 expression in cells and tissues of PC were measured by quantitative real-time PCR and western blot, respectively. Knock-down of GRIM-19 in PC cells was performed using siRNA. Cell apoptosis was determined by flow cytometric analysis. DNA damage in PC cells was detected by γ-H2AX staining. GRIM-19 was downregulated in PC tissues and cell lines. Knockdown of GRIM-19 increased the resistance of PC cells to docetaxel, and overexpression of GRIM-19 promoted ...
Source: Clinical and Experimental Pharmacology and Physiology - September 16, 2019 Category: Drugs & Pharmacology Authors: Lin H, Shen Z, Liu H, Yang M, Lin J, Luo L, Liu L, Chen H Tags: Clin Exp Pharmacol Physiol Source Type: research

Docetaxel-triggered SIDT2/NOX4/JNK/HuR signaling axis is associated with TNF- α-mediated apoptosis of cancer cells
Biochem Pharmacol. 2021 Dec 2:114865. doi: 10.1016/j.bcp.2021.114865. Online ahead of print.ABSTRACTPrevious studies have confirmed that docetaxel (DTX) treatment increases TNF-α production in cancer cells, but its mechanism of action remains unclear. Therefore, this study aimed to determine the signaling axis by which DTX induced the expression of TNF-α in U937 leukemia and MCF-7 breast carcinoma cells. DTX treatment promoted Ca2+-controlled autophagy and SIDT2 expression, resulting in lysosomal degradation of miR-25 in U937 cells. Downregulation of miR-25 increased NOX4 mRNA stability and protein expression. NOX4-stimu...
Source: Biochemical Pharmacology - December 5, 2021 Category: Drugs & Pharmacology Authors: Liang-Jun Wang Jing-Ting Chiou Yuan-Chin Lee Long-Sen Chang Source Type: research