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Discovery of Alpha-Gal-Containing Antigens in North American Tick Species Believed to Induce Red Meat Allergy
In this study, we investigated the presence of α-gal in four tick species: the lone-star tick (Amblyomma americanum), the Gulf-Coast tick (Amblyomma maculatum), the American dog tick (Dermacentor variabilis), and the black-legged tick (Ixodes scapularis) by using a combination of immunoproteomic approach and , carbohydrate analysis., and basophil activation approaches. Using aAnti-α-gal antibodies, α-gal was identified α-gal in the salivary glands of both Am. americanum and Ix. scapularis, while Am. maculatum and De. variabilis appeared to lack the sugarcarbohydrate. PNGase F treatment confirmed the deglycosylation of ...
Source: Frontiers in Immunology - May 16, 2019 Category: Allergy & Immunology Source Type: research

Scientific abstracts for RhinoWorld 2019
AbstractIt has been a decade since the world's rhinologic community gathered in the United States for RhinoWorld. The American Rhinologic Society (ARS), International Rhinologic Society (IRS), and International Society of Inflammation and Allergy of the Nose (ISIAN) have joined together to host this international gathering of clinicians and scientists.Herein, you will find the abstracts that will be presented orally during RhinoWorld on June 5 ‐9, 2019, in Chicago, IL. This IFAR supplement serves as an informational centerpiece for cutting edge discovery and innovation, and commentary and debate, for clinicians and resea...
Source: International Forum of Allergy and Rhinology - June 2, 2019 Category: Allergy & Immunology Authors: Timothy L. Smith Tags: ABSTRACTS Source Type: research

Despite the Safety of Preoperative Cefazolin for Patients With Non-anaphylactic Penicillin Allergy, 20% of Practitioners Avoid Its Use.
Abstract Cefazolin is commonly used for surgical site infection prophylaxis due to its low cost and effective coverage. However, it is controversial to use cefazolin in patients with a penicillin allergy despite the cross-reactivity between cefazolin and penicillin being only 1%. Ample literature shows that it is safe to use cefazolin in patients with non-anaphylactic penicillin allergies. However, there is often hesitation by anesthesiologists or orthopedists when prescribing this medication in this population. The current authors sent a 16-question survey to all the residency programs in the United States in ane...
Source: Orthopedics - June 10, 2019 Category: Orthopaedics Authors: Pettett BJ, Eskildsen SM, Huang KX, Ostrum RF Tags: Orthopedics Source Type: research

Dangerous Sesame Allergy Affects Many Americans
FRIDAY, Aug. 2 , 2019 -- More than 1.5 million children and adults in the United States have sesame allergy -- more than previously believed, a new study finds. And even though sesame allergy can cause severe reactions, sesame is often not declared...
Source: Drugs.com - Daily MedNews - August 2, 2019 Category: General Medicine Source Type: news

Peanut oral immunotherapy induces blocking antibodies but does not change the functional characteristics of peanut-specific IgE
Peanut allergy is one of the most common and severe food allergies, affecting about 2% of school-aged children in the United Kingdom and United States. Current management of peanut allergy consists of strict allergen avoidance and carrying emergency medication to treat acute allergic reactions that can develop after accidental exposure.
Source: Journal of Allergy and Clinical Immunology - October 28, 2019 Category: Allergy & Immunology Authors: Alexandra F. Santos, Louisa K. James, Matthew Kwok, Richard T. McKendry, Katherine Anagnostou, Andrew T. Clark, Gideon Lack Tags: Letter to the editor Source Type: research

M312 a case for oral challenge in patients with high peanut sensitivity to guide treatment decisions
Peanut allergy prevalence is increasing in the United States; it is a persistent allergy and common etiology of fatal and near-fatal anaphylaxis. Oral immunotherapy (OIT) is increasingly available to desensitize peanut-allergic children but optimal patient selection remains unknown.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: K. Tison, K. Patel, B. Vickery Source Type: research

A Retrospective Cohort Study of Pediatrician Implementation of 2017 United States Early Peanut Introduction Guidelines
The National Institute of Allergy and Infectious Disease (NIAID) released addendum guidelines for the prevention of peanut allergy (PA) (1) recommending peanut-introduction to at-risk infants prior to twelve months of age in an effort to prevent PA development, based on data from the landmark Learning Early About Peanut-introduction study (2). Surveys have demonstrated low rates of self-reported adherence to these recommendations (3,4, 5). The goal of this study was to assess how the 2017 peanut-introduction guidelines were addressed in the primary care setting.
Source: Annals of Allergy, Asthma and Immunology - October 29, 2020 Category: Allergy & Immunology Authors: David Tapke, Benjamin Prince, Rebecca Scherzer, David Stukus, Irene Mikhail Tags: Letters Source Type: research

A retrospective cohort study of pediatrician implementation of the 2017 United States early peanut introduction guidelines
The National Institute of Allergy and Infectious Diseases released the addendum guidelines for the prevention of peanut allergy (PA)1 recommending peanut introduction to at-risk infants before 12 months of age in an effort to prevent PA development, based on data from the landmark Learning Early About Peanut Introduction study.2 Surveys have revealed low rates of self-reported adherence to these recommendations.3-5 The goal of this study was to assess how the 2017 peanut-introduction guidelines were addressed in the primary care setting.
Source: Annals of Allergy, Asthma and Immunology - October 29, 2020 Category: Allergy & Immunology Authors: David Tapke, Benjamin Prince, Rebecca Scherzer, David Stukus, Irene Mikhail Tags: Letters Source Type: research

Erratum
In the article “Risk of physician burnout in the North American allergist-immunologist workforce: A report from the American College of Allergy, Asthma and Immunology Physician Wellness Taskforce” by Marshall et al (Ann Allergy Asthma Immunol 2020;125:235-243), Figure 4 was incorrect. The article has been co rrected online at https://www.annallergy.org/article/S1081-1206(20)30405-1/fulltext.
Source: Annals of Allergy, Asthma and Immunology - November 18, 2020 Category: Allergy & Immunology Tags: Erratum Source Type: research

Fragrance- and Botanical-Related Allergy and Associated Concomitant Reactions: A Retrospective Analysis of the North American Contact Dermatitis Group Data 2007-2016.
CONCLUSIONS: Concomitant reactions were identified between fragrances, between fragrances and BR allergens, and between BR allergens and fragrances. If CRs of greater than 10% suggest cross-reactivity, then all patients with fragrance sensitivity should avoid BR allergens and vice versa. PMID: 33273222 [PubMed - as supplied by publisher]
Source: Dermatitis - December 1, 2020 Category: Dermatology Authors: Atwater AR, Ward JM, Liu B, Green CL, Belsito DV, Sasseville D, DeKoven JG, Reeder MJ, Taylor JS, Maibach HI, Silverberg JI, Zug KA, Fowler JF, Pratt MD, DeLeo VA, Warshaw EM Tags: Dermatitis Source Type: research

The Heterogeneity Of State-Specific Epinephrine Training Program Listing Requirements In The United States
The nation-wide incidence of food allergy continues to increase, and about 18% of K-12 students with food allergy have had a reaction at school. To combat this problem, the Code Ana Program created a comprehensive, online Epinephrine Training Course, designed to teach school faculty and staff how to recognize the signs and symptoms of anaphylaxis and to administer epinephrine in an emergency. The process of listing the course on each state ’s website revealed the complexities and differences in health-programming implementation in each state.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Madison Oxford, Alice Hoyt Source Type: research

Food protein-induced enterocolitis syndrome to nuts
Food protein-induced enterocolitis syndrome (FPIES) is a non –immunoglobulin E (IgE)-mediated food allergy which typically presents in infancy. Although rice is a rare cause of IgE-mediated food allergy, it is one of the most common triggers of FPIES in Australia and the United States.1,2 Conversely, peanut and tree nuts are rarely described to cause FPIES, but are common triggers of IgE-mediated food reactions. Ruffner et al2 reported peanut and tree nut FPIES in only 2% and less than 1% of children, respectively, in a retrospective cohort of 462 children from a single institution.
Source: Annals of Allergy, Asthma and Immunology - February 13, 2021 Category: Allergy & Immunology Authors: Samara Baldwin, Rebecca Werther, Ania Hargrove, Aikaterini Anagnostou, Sam Mehr Tags: Perspective Source Type: research

Functional constipation related to cow's milk allergy in children: A management proposal
Allergol Immunopathol (Madr). 2021 May 1;49(3):17-20. doi: 10.15586/aei.v49i3.72. eCollection 2021.ABSTRACTFunctional constipation (FC) is one of the most common disorders in childhood and has a negative impact on the quality of life of children. Scientific evidence regarding a causal relationship between FC and cow's milk allergy is controversial, as it is also reported by the latest European Society for Paediatric Gastroenterology, Hepatology and Nutrition-North American Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN-NASPGHAN) recommendations. In the case of FC, routine allergometric tests are...
Source: Allergologia et Immunopathologia - May 3, 2021 Category: Allergy & Immunology Authors: Mariannita Gelsomino Ester Del Vescovo Giulia Bersani Stefano Miceli Sopo Source Type: research