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Janssen and Global Partners to Discontinue Phase 3 Mosaico HIV Vaccine Clinical Trial
LEIDEN, THE NETHERLANDS, (January 18, 2023) – The Janssen Pharmaceutical Companies of Johnson & Johnson, together with a consortium of global partners, today announced the results of an independent, scheduled data review of the Phase 3 Mosaico study (also known as HPX3002/HVTN706) of Janssen’s investigational HIV vaccine regimen. The study’s independent Data and Safety Monitoring Board (DSMB) determined that the regimen was not effective in preventing HIV infection compared to placebo among study participants. No safety issues with the vaccine regimen were identified.In light of the DSMB’s determination, the Mo...
Source: Johnson and Johnson - January 18, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

The Great Vaccine Race: Inside the Unprecedented Scramble to Immunize the World Against COVID-19
The cleverest of enemies thrive on surprise attacks. Viruses—and coronaviruses in particular—know this well. Remaining hidden in animal hosts for decades, they mutate steadily, sometimes serendipitously morphing into more effective and efficient infectious agents. When a strain with just the right combination of genetic codes that spell trouble for people makes the leap from animal to human, the ambush begins. Such was the case with SARS-CoV-2, the coronavirus behind COVID-19, and the attack was mostly silent and insidious at first. Many people infected with SARS-CoV-2 remained oblivious as they served as the v...
Source: TIME: Health - September 10, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Magazine Source Type: news

Why the U.S. Is Losing the War On COVID-19
It is a frightening time to live in the United States. COVID-19, a novel disease as ruthless as it is seemingly random, is picking us off by the thousands; even many of those who “recover” may never truly be the same again. The pandemic has exposed the gulf between what this country promises for its citizens and what it actually delivers. And as the U.S. barrels toward Election Day, the outbreak is sure to complicate the voting process, with potentially disastrous results. For a short time in the spring, it appeared the U.S. was getting a grip on its outbreak. Hard-hit states like New York successfully flattene...
Source: TIME: Science - August 13, 2020 Category: Science Authors: Alex Fitzpatrick Tags: Uncategorized COVID-19 UnitedWeRise20Disaster Source Type: news

What the U.S. Needs to do Today to Follow South Korea ’s Model for Fighting Coronavirus
The United States has a narrow window of opportunity to determine the fate of its coronavirus crisis. Will we end up looking like Italy or South Korea? Italy’s health system has imploded under the strain of new cases and the shortage of ventilators means doctors must make agonizing decisions on who to save and who to let die. In contrast, South Korea acted swiftly and boldly to “flatten the curve”— the government did everything it could to slow the rate of increase and so reduce the burden of the illness on the country’s clinics and hospitals. Right now, the number of new cases of confirmed in...
Source: TIME: Health - March 17, 2020 Category: Consumer Health News Authors: Gavin Yamey Tags: Uncategorized COVID-19 Source Type: news

China ’s Draconian Lockdown Is Getting Credit for Slowing Coronavirus. Would It Work Anywhere Else?
As COVID-19 spread rapidly across China, authorities took an aggressive stance to fight the coronavirus. They were slow to respond to the outbreak—at first suppressing information and denying that it could spread between humans even as it did just that. But, as case numbers skyrocketed, Beijing went to extraordinary lengths to fight the virus, identified at COVID-19, in a campaign Chinese President Xi Jinping has described as a “people’s war.” The most dramatic, and controversial, of the measures was the lockdown of of tens of millions of people in what is believed to be the largest quasi-quarantin...
Source: TIME: Health - March 13, 2020 Category: Consumer Health News Authors: Amy Gunia Tags: Uncategorized COVID-19 overnight Source Type: news

World Health Organization Declares COVID-19 a ‘Pandemic.’ Here’s What That Means
The World Health Organization (WHO) on March 11 declared COVID-19 a pandemic, pointing to the over 118,000 cases of the coronavirus illness in over 110 countries and territories around the world and the sustained risk of further global spread. “This is not just a public health crisis, it is a crisis that will touch every sector,” said Dr. Tedros Adhanom Ghebreyesus, WHO director-general, at a media briefing. “So every sector and every individual must be involved in the fights.” An epidemic refers to an uptick in the spread of a disease within a specific community. By contrast, the WHO defines a pand...
Source: TIME: Health - March 11, 2020 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 Source Type: news

Developing an Intervention to Improve the Health Related Quality of Life in Children and Young People With Serious Parental Mental Illness
Conclusion: Young SMILES captures a broad age range and level of need for CAPRI and can be evaluated with quantifiable child-centered outcomes. In line with current policy directives, this is the first UK-based, multi-context intervention to improve QoL in this population. Implementation and referral mechanisms are currently being evaluated in a multi-site feasibility trial. Introduction Children and adolescents living with parental mental illness (CAPRI) are poorly provided for in current social care and educational settings (1, 2). Children and young people (CYP) growing up in families affected by parental mental h...
Source: Frontiers in Psychiatry - April 8, 2019 Category: Psychiatry Source Type: research

Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization
Conclusions: Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene. https://doi.org/10.1289/EHP685 Received: 19 June 2016 Revised: 07 June 2017 Accepted: 19 June 2017 Published: 13 September 2017 Address correspondence to N. Sang, College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, P...
Source: EHP Research - September 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Weekly Personal Ozone Exposure and Respiratory Health in a Panel of Greek Schoolchildren
Conclusions: The study provides evidence that airway inflammation and the frequency of respiratory symptoms increase, whereas lung function decreases with increased ozone exposure in schoolchildren. https://doi.org/10.1289/EHP635 Received: 09 June 2016 Revised: 08 March 2017 Accepted: 13 March 2017 Published: 21 July 2017 Please address correspondence to A. Karakatsani, 2nd Pulmonary Department, ATTIKON University Hospital, School of Medicine, National and Kapodistrian University of Athens, 1, Rimini St., 124 62 Haidari, Greece. Telephone: 30-210-5831184. Email: annakara@otenet.gr, akarakats@med.uoa.gr The authors de...
Source: EHP Research - July 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research