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Intravenous Thrombolysis for Acute Ischemic Stroke in the Elderly: An Italian Cohort Study in a “Real World” Setting
Conclusion Thrombolysis in patients aged >80 years was not associated with significantly increased intracranial hemorrhage. The higher 3-month disability rate observed in octogenarians may be explained by the more severe stroke and higher poststroke disability. Based on the current, “real world setting” study, we advocate the need for a randomized clinical trial to better clarify the efficacy and safety of intravenous thrombolysis for acute ischemic stroke in the elderly.
Source: International Journal of Gerontology - March 10, 2015 Category: Geriatrics Source Type: research

Becoming Centenarians: Disease and Functioning Trajectories of Older U.S. Adults as They Survive to 100
Conclusions. While some centenarians have poor health and functioning upon reaching age 100, others are able to achieve exceptional longevity in relatively good health and without loss of functioning. This study underscores the importance of examining variation in the growing centenarian population.
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 21, 2015 Category: Geriatrics Authors: Ailshire, J. A., Beltran-Sanchez, H., Crimmins, E. M. Tags: Research Article Source Type: research

Suicide in Stroke Survivors: Epidemiology and Prevention
Abstract Stroke is a dramatic event and is associated with potentially severe consequences, including disability, mortality, and social costs. Stroke may occur at any age; however, most strokes occur in individuals aged 65 years and older. Previous research has found that stroke increases suicide risk, especially among women and younger patients. The aim of the current review is to investigate the relationship between suicide and stroke in order to determine which stroke patients are at elevated risk for suicide. Moreover, we review the literature in order to provide pharmacological treatment strategies for strok...
Source: Drugs and Aging - December 10, 2014 Category: Geriatrics Source Type: research

Thyroid function tests and early outcomes of acute ischemic stroke in older euthyroid patients.
Abstract Blood thyroid function tests (TFT) are routinely used to screen for thyroid disorders in several clinical settings. TFT on hospital admission may also be useful prognostic predictors of acute IS: according to recent evidence, poststroke outcome is better in patients with lower thyroid function and worse in those with higher thyroid function. However, previous reports are few and mostly compared patients with thyroid disorders to euthyroid patients. Thyroid disorders are known risk factors for cerebrovascular disease. However, hyperthyroidism is related to cardioembolic IS whereas hypothyroidism is related...
Source: Experimental Gerontology - November 18, 2014 Category: Geriatrics Authors: Forti P, Maioli F, Coveri M, Nativio V, Arnone G, Loreti A, Zoli M, Sacquegna T, Procaccianti G Tags: Exp Gerontol Source Type: research

Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study
ConclusionOur findings confirm previous findings of a positive effect of physical activity on cognitive functions in elderly subjects, and further extends these by showing that the association is also present in patients with ARWMC. Copyright © 2014 John Wiley & Sons, Ltd.
Source: International Journal of Geriatric Psychiatry - November 3, 2014 Category: Geriatrics Authors: Kristian Steen Frederiksen, Ana Verdelho, Sofia Madureira, Hansjörg Bäzner, John T. O'Brien, Franz Fazekas, Philip Scheltens, Reinhold Schmidt, Anders Wallin, Lars‐Olof Wahlund, Timo Erkinjunttii, Anna Poggesi, Leonardo Pantoni, Domenico Inzitari, Gun Tags: Research Article Source Type: research

The Role of Accommodations in Poststroke Disability Management
Discussion. Although accommodations are commonly used by older adult stroke survivors, unmet need is also substantial. Future research should focus on finding ways to improve poststroke functional capacity and cognitive capacity and enhance adoption of assistive devices with the aim of reducing unmet need.
Source: Journals of Gerontology: Series B Psychological Sciences and Social Sciences - October 23, 2014 Category: Geriatrics Authors: Skolarus, L. E., Burke, J. F., Freedman, V. A. Tags: Special Article Source Type: research

Compensating for Memory Losses throughout aging: Validation and Normalization of the Memory Compensation Questionnaire for Non-Clinical French Populations
Memory impairments due to pathological aging, brain injury or stroke are major causes of disability in our society. These impairments may be seen in the reduced ability to function adequately in everyday life. For aging people, coping with these memory problems is therefore of major importance in maintaining one's level of independence. Memory impairment often results in an increase in memory compensation strategies use that gives room to elderlies to be flexible and adapt to change course (Dixon & Bäckman, 1995; Dixon, Garrett, & Bäckman, 2008).
Source: Archives of Gerontology and Geriatrics - October 21, 2014 Category: Geriatrics Authors: Sophie Martin, Clémence Mazzocco, Pascale Maury, Anne Grosselin, Wim Van der Elst, Roger A. Dixon, Denis Brouillet Source Type: research

Association between estimated glomerular filtration rate and clinical outcomes in patients with acute ischaemic stroke: results from China National Stroke Registry
Conclusions: a low eGFR was associated with increased risks of all-cause mortality and recurrent stroke independent of the traditional vascular risk factors in Chinese stroke patients.
Source: Age and Ageing - October 21, 2014 Category: Geriatrics Authors: Wang, X., Wang, Y., Wang, C., Zhao, X., Xian, Y., Wang, D., Liu, L., Luo, Y., Liu, G., Wang, Y. Tags: Research Papers Source Type: research

Age-dependent modifications in vascular adhesion molecules and apoptosis after 48-h reperfusion in a rat global cerebral ischemia model
Abstract Stroke is one of the leading causes of death and permanent disability in the elderly. However, most of the experimental studies on stroke are based on young animals, and we hypothesised that age can substantially affect the stroke response. The two-vessel occlusion model of global ischemia by occluding the common carotid arteries for 15 min at 40 mmHg of blood pressure was carried out in 3- and 18-month-old male Sprague–Dawley rats. The adhesion molecules E- and P-selectin, cell adhesion molecules (CAMs), both intercellular (ICAM-1) and vascular (VCAM-1), as well as glial fibrillary acidic protein (G...
Source: AGE - September 3, 2014 Category: Geriatrics Source Type: research

Observational assessment of communication disorders in vascular dementia patients with right hemisphere damage
ConclusionWe believe that communication disorder in the RBD patients may be evaluated with the DCAS. We plan to standardize the DCAS and apply it for use in rehabilitation in the future.
Source: Psychogeriatrics - September 1, 2014 Category: Geriatrics Authors: Miyuki Kawada, Naofumi Tanaka, Satoshi Yamaguchi, Kenichi Meguro Tags: ORIGINAL ARTICLE Source Type: research

The Influence of Mood-Related Variables on Activity and Participation in Individuals With Chronic Stroke
Little information exists about the influence of mood-related variables on the activity and participation of survivors of chronic stroke despite the known implications of anxiety and depression on overall participation patterns. Grounded within International Classification of Functioning, Disability, and Health, this study examined 77 individuals with chronic stroke to determine the influence of depression, anxiety, and sense of coherence on activity and participation. Backward stepwise regression revealed that depression and anxiety were both independent predictors of activity and participation, but that sense of coherenc...
Source: Topics in Geriatric Rehabilitation - July 1, 2014 Category: Geriatrics Tags: Special Features Source Type: research

Natural history, predictors and associated outcomes of anxiety up to 10 years after stroke: the South London Stroke Register
Conclusions: anxiety is a frequent problem affecting stroke survivors in the long term. Clinicians should pay attention to patients at risk of anxiety since it is associated with lower QoL and depression.
Source: Age and Ageing - June 23, 2014 Category: Geriatrics Authors: Ayerbe, L., Ayis, S. A., Crichton, S., Wolfe, C. D. A., Rudd, A. G. Tags: Research Papers Source Type: research

Ageism in stroke rehabilitation studies
Conclusion: we have identified a clear difference in the mean age of those included in stroke rehabilitation studies compared with the international mean age of stroke. In addition, a quarter of trials excluded dysphasic patients which may indicate omission of more severe strokes. This means that the evidence base for stroke rehabilitation is deficient in terms of matching the characteristics of patients encountered in clinical practice, and a more representative sample of older people and those with significant disability must be included in future trials.
Source: Age and Ageing - April 28, 2014 Category: Geriatrics Authors: Gaynor, E. J., Geoghegan, S. E., O'Neill, D. Tags: Short Reports Source Type: research

Identifying factors associated with changes in physical functioning in an older population
ConclusionsOlder persons with stroke, Parkinson's disease, diabetes, osteoporosis, geriatric conditions and poor short physical performance battery score should be considered as the target of prevention against functional decline. Those not living with spouses, with poor self‐rated health, with low social support, being underweight or obese and with a sedentary lifestyle might also require major attention. Geriatr Gerontol Int 2014; ●●: ●●–●●.
Source: Geriatrics and Gerontology International - February 1, 2014 Category: Geriatrics Authors: Chun‐Min Chen, Wen‐Chiung Chang, Tzuo‐Yun Lan Tags: Review Article Source Type: research

Quality indicators in acute stroke care: a prospective observational survey in 13 Italian regions.
CONCLUSIONS: Our data confirm the need of quality monitoring in stroke care. Although SU patients showed a better adherence to quality indicators, overall compliance was unsatisfactory. PMID: 24293350 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - November 29, 2013 Category: Geriatrics Authors: Di Carlo A, Accetta G, Bellan M, Terni G, Lamassa M, Facchini R, Biggeri A, Inzitari D, Ferro S, For the National Stroke Care Group Tags: Aging Clin Exp Res Source Type: research

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