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Condition: Disability
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Total 13528 results found since Jan 2013.
URB597 exerts neuroprotective effects against transient brain ischemia injury in mice by regulating autophagic flux and necroptosis
In conclusion, URB597 exerts a neuroprotective effect in a dose- and time-dependent manner, and this effect may be related to its restoration of autophagic flux and inhibition of neuronal necroptosis. PPARα is involved in the neuroprotective effect of URB597. This study provides novel evidence that URB597 may be a promising agent for the clinical treatment of ischemic stroke.PMID:37572942 | DOI:10.1016/j.ejphar.2023.175982
Source: European Journal of Pharmacology - August 12, 2023 Category: Drugs & Pharmacology Authors: Xiaoqian Yuan Wenxuan Ye Ling Chen Doudou Luo Li Zhou Yan Qiu Rengong Zhuo Yun Zhao Lu Peng Lichao Yang Xin Jin Yu Zhou Source Type: research
Telerehabilitation Following Stroke
Stroke remains a major cause of disability. Intensive rehabilitation therapy can improve outcomes, but most patients receive limited doses. Telehealth methods can overcome obstacles to delivering intensive therapy and thereby address this unmet need. A specific example is reviewed in detail, focused on a telerehabilitation system that targets upper extremity motor deficits after stroke. Strengths of this system include provision of daily therapy associated with very high patient compliance, safety and feasibility in the inpatient or home setting, comparable efficacy to dose-matched therapy provided in-clinic, and a holisti...
Source: Physical Medicine and Rehabilitation Clinics of North America - August 12, 2023 Category: Rehabilitation Authors: Steven C. Cramer, Brittany M. Young, Anne Schwarz, Tracy Y. Chang, Michael Su Source Type: research
Predicting severe disability or death in endovascular thrombectomy with large computed tomography perfusion core infarction and limited penumbra
CONCLUSION: CLEOS predicts devastating outcomes after EVT in patients with large core infarctions and small volumes of ischemic penumbra.PMID:37563964 | DOI:10.1177/15910199231193466
Source: Interventional Neuroradiology - August 11, 2023 Category: Radiology Authors: Rahul R Karamchandani Sagar Satyanarayana Hongmei Yang Jeremy B Rhoten Dale Strong Jonathan D Clemente Gary Defilipp Nikhil M Patel Joe Bernard William R Stetler Jonathan M Parish Amy K Guzik Stacey Q Wolfe Andrew W Asimos Source Type: research
Interventions for the uptake of evidence-based recommendations in acute stroke settings
CONCLUSIONS: We are uncertain whether a multifaceted implementation intervention compared to no intervention improves adherence to evidence-based recommendations in acute stroke settings, because the certainty of evidence is very low.PMID:37565934 | PMC:PMC10416310 | DOI:10.1002/14651858.CD012520.pub2
Source: Cochrane Database of Systematic Reviews - August 11, 2023 Category: General Medicine Authors: Elizabeth A Lynch Lemma N Bulto Heilok Cheng Louise Craig Julie A Luker Kathleen L Bagot Tharshanah Thayabaranathan Heidi Janssen Elizabeth McInnes Sandy Middleton Dominique A Cadilhac Source Type: research
WHO Systematic Assessment of Rehabilitation Situation (STARS): A systematic review on the status of stroke rehabilitation in India
AbstractPurpose of reviewTo provide a 'Systematic Assessment of the Rehabilitation Situation' (STARS) on stroke rehabilitation in India in accordance with the World Health Organization (WHO) STARS guidelines. Understanding the current status will help in planning of future policy and development activities.Recent FindingsThe available stroke rehabilitation data from India is deficient. While the incidence of stroke is 33 to 295.9 per year per 100,000 people (in a country of 1.2 billion), there are about 1000 physiatrists and only 150 designated rehabilitation facilities. Among them almost 40% patients are moderate to sever...
Source: Current Physical Medicine and Rehabilitation Reports - August 11, 2023 Category: Rehabilitation Source Type: research
Integrating Cardiac Rehabilitation in Stroke Recovery
Stroke remains a top contributor to long-term disability in the United States and substantially limits a person ’s physical activity. Decreased cardiovascular capacity is a major contributing factor to activity limitations and is a significant health concern. Addressing the cardiovascular capacity of stroke survivors as part of poststroke management results in significant improvements in their endurance, fu nctional recovery, and medical outcomes such as all-cause rehospitalization and mortality. Incorporation of a structured approach similar to the cardiac rehabilitation program, including aerobic exercise and risk fact...
Source: Physical Medicine and Rehabilitation Clinics of North America - August 11, 2023 Category: Rehabilitation Authors: Sara J. Cuccurullo, Talya K. Fleming, Hayk Petrosyan Source Type: research
The impact on clinical outcomes after 1 year of implementation of an artificial intelligence solution for the detection of intracranial hemorrhage
ConclusionThe added value of this study emphasizes the introduction of artificial intelligence (AI) computer-aided triage and prioritization software in an emergent care setting that demonstrated a significant reduction in a 30- and 120-day all-cause mortality and morbidity for patients diagnosed with intracranial hemorrhage (ICH). Along with mortality rates, the AI software was associated with a significant reduction in the Modified Ranking Scale (mRs).
Source: International Journal of Emergency Medicine - August 11, 2023 Category: Emergency Medicine Source Type: research
Stroke in the Developing Brain: Neurophysiological Implications of Stroke Timing, Location, and Comorbid Factors
Pediatric stroke, which is unique in that it represents a static insult to a developing brain, often leads to long-term neurological disability. Neuroplasticity in infants and children influences neurophysiologic recovery patterns after stroke therefore outcomes depend on several factors including timing and location of stroke and the presence of comorbid conditions.
Source: Pediatric Neurology - August 11, 2023 Category: Neurology Authors: Nayo M. Hill, Laura A. Malone, Lisa R. Sun Source Type: research
COVID-19 ’ s Impact on Heart Health Still Confounds Doctors
(ST. LOUIS) — Firefighter and paramedic Mike Camilleri once had no trouble hauling heavy gear up ladders. Now battling long COVID, he gingerly steps onto a treadmill to learn how his heart handles a simple walk.
“This is, like, not a tough-guy test so don’t fake it,” warned Beth Hughes, a physical therapist at Washington University in St. Louis.
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Somehow, a mild case of COVID-19 set off a chain reaction that eventually left Camilleri with dangerous blood pressure spikes, a heartbeat that raced with slight exertion, and episodes of intense chest pain...
Source: TIME: Health - August 10, 2023 Category: Consumer Health News Authors: Lauran Needgaard/ Associated Press Tags: Uncategorized COVID-19 healthscienceclimate wire Source Type: news
The Role of Progranulin (PGRN) in the Pathogenesis of Ischemic Stroke
Cell Mol Neurobiol. 2023 Aug 10. doi: 10.1007/s10571-023-01396-8. Online ahead of print.ABSTRACTStroke is a life-threatening medical condition and is a leading cause of disability. Cerebral ischemia is characterized by a distinct inflammatory response starting with the production of various cytokines and other inflammation-related agents. Progranulin (PGRN), a multifunctional protein, is critical in diverse physiological reactions, such as cell proliferation, inflammation, wound healing, and nervous system development. A mature PGRN is anti-inflammatory, while granulin, its derivative, conversely induces pro-inflammatory c...
Source: Cellular and Molecular Neurobiology - August 10, 2023 Category: Cytology Authors: Daryush Purrahman Ali Shojaeian Łukasz A Poniatowski Bart łomiej Piechowski-Jóźwiak Mohammad-Reza Mahmoudian-Sani Source Type: research
