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Total 49 results found since Jan 2013.

Mesenchymal stem cells for ischemic stroke: progresses and possibilities.
Abstract Stroke is the most common reason of death and quality of life impairments due to neurological deficits in industrialized countries, currently afflicting 15 million people every year, and the numbers are expected to increase, mostly due to population aging. Although some acute phase therapies such as intravenous recombinant tissue plasminogen activator (rt-PA) and more recently endovascular treatment have been identified to improve stroke outcome, these therapies are available only for a small proportion of patients. The social and economic impact of stroke is immense because one of five stroke patient's d...
Source: Current Medicinal Chemistry - February 21, 2016 Category: Chemistry Authors: Ferri AL, Bersano A, Lisini D, Boncoraglio G, Frigerio S, Parati E Tags: Curr Med Chem Source Type: research

Increased Growth Differentiation Factor 15 Is Associated with Unfavorable Clinical Outcomes of Acute Ischemic Stroke Proteomics and Protein Markers
CONCLUSIONS: High GDF-15 concentrations are independently associated with adverse clinical outcomes of acute ischemic stroke, suggesting that baseline serum GDF-15 could provide additional information to identify ischemic stroke patients at high risk of poor prognosis.
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Yin, J., Zhu, Z., Guo, D., Wang, A., Zeng, N., Zheng, X., Peng, Y., Zhong, C., Wang, G., Zhou, Y., Chen, C.-S., Chen, J., Zhang, Y., He, J. Tags: Proteomics and Protein Markers Source Type: research

Multi-modal imaging of long term recovery post-stroke by PET and MALDI-MS.
CONCLUSIONS: The data demonstrates the ability to combine MALD-MS with in vivo PET to image different aspects of stroke recovery. PMID: 29484723 [PubMed - as supplied by publisher]
Source: Rapid Communications in Mass Spectrometry : RCM - February 27, 2018 Category: Chemistry Authors: Henderson F, Hart PJ, Pradillo JM, Kassiou M, Christie L, Williams KJ, Boutin H, McMahon A Tags: Rapid Commun Mass Spectrom Source Type: research

Novel potent antiplatelet thrombotic agent derived from biguanide for ischemic stroke.
Abstract Platelet thrombosis is the main pathogeny resulting in the low curability of ischemic stroke, a leading cause of mortality and disability worldwide. Metformin, a biguanide derivative that is the first-line oral medicine for type 2 diabetes, alleviates the severity of ischemic stroke in diabetic patients and suppresses platelet activation in experimental animal model. However, the clinical implementation of commercial biguanide analogs for stroke related to platelet thrombosis remains challenging due to its weak potency, poor pharmacokinetic characteristics and possible hypoglycemia. Here, twenty-three big...
Source: European Journal of Medicinal Chemistry - May 17, 2020 Category: Chemistry Authors: Xin G, Ming Y, Ji C, Wei Z, Li S, Morris-Natschke SL, Zhang X, Yu K, Li Y, Zhang B, Zhang J, Xing Z, He Y, Chen Z, Yang X, Niu H, Lee KH, Huang W Tags: Eur J Med Chem Source Type: research

Molecules, Vol. 26, Pages 5001: The Nrf2 Pathway in Ischemic Stroke: A Review
ano Saso Ischemic stroke, characterized by the sudden loss of blood flow in specific area(s) of the brain, is the leading cause of permanent disability and is among the leading causes of death worldwide. The only approved pharmacological treatment for acute ischemic stroke (intravenous thrombolysis with recombinant tissue plasminogen activator) has significant clinical limitations and does not consider the complex set of events taking place after the onset of ischemic stroke (ischemic cascade), which is characterized by significant pro-oxidative events. The transcription factor Nuclear factor erythroid 2-related factor...
Source: Molecules - August 18, 2021 Category: Chemistry Authors: Marcelo Farina Leonardo Eug ênio Vieira Brigitta Buttari Elisabetta Profumo Luciano Saso Tags: Review Source Type: research

The emerging role of microRNA in stroke.
Abstract MicroRNAs (miRNAs) are small non-coding RNAs approximately 22 nucleotides in length that play a pivotal role in post-transcriptional gene regulation by binding to complementary sites in the 3'-untranslated region of messenger RNAs. In the past decade, their role in several human diseases, from cancer to cardiovascular disease, has been established by a wealth of evidence. Stroke is responsible for 10% of deaths worldwide and is one of the leading causes of disability. MiRNAs are involved in stroke risk factors including hypertension, atherosclerosis, atrial fibrillation, diabetes and dyslipidemia. The rol...
Source: Current Topics in Medicinal Chemistry - May 31, 2013 Category: Chemistry Authors: Koutsis G, Siasos G, Spengos K Tags: Curr Top Med Chem Source Type: research

Synaptic and Extrasynaptic Glutamate Signaling in Ischemic Stroke.
Abstract Stroke is a leading cause of human mortality and disability where most cases of stroke are ischemic. The central nervous system (CNS) is extremely vulnerable to ischemic stroke particularly due to its unique ability: synaptic transmission. Not only does elaborate synaptic transmission consume extravagant energy that constrains neuronal viability under ischemic conditions, but glutamate, the most predominant neurotransmitter in the CNS, also triggers several catastrophic signaling cascades at both synaptic and extrasynaptic sites when excessively released. These signaling cascades accelerate neuronal death...
Source: Current Medicinal Chemistry - December 28, 2013 Category: Chemistry Authors: Chao N, Sheng-Tian L Tags: Curr Med Chem Source Type: research

Innate Inflammatory Responses in Stroke: Mechanisms and Potential Therapeutic Targets.
Abstract Stroke is a frequent cause of long-term disability and death worldwide. Ischemic stroke is more commonly encountered compared to hemorrhagic stroke, and leads to tissue death by ischemia due to occlusion of a cerebral artery. Inflammation is known to result as a result of ischemic injury, long thought to be involved in initiating the recovery and repair process. However, work over the past few decades indicates that aspects of this inflammatory response may in fact be detrimental to stroke outcome. Acutely, inflammation appears to have a detrimental effect, and anti-inflammatory treatments have been been ...
Source: Current Medicinal Chemistry - December 28, 2013 Category: Chemistry Authors: Kim JY, Kawabori M, Yenari MA Tags: Curr Med Chem Source Type: research

Molecules, Vol. 21, Pages 1143: In Vivo Targeted MR Imaging of Endogenous Neural Stem Cells in Ischemic Stroke
Acute ischemic stroke remains a leading cause of death and disability. Endogenous neurogenesis enhanced via activation of neural stem cells (NSCs) could be a promising method for stroke treatment. In vivo targeted tracking is highly desirable for monitoring the dynamics of endogenous NSCs in stroke. Previously, we have successfully realized in vivo targeted MR imaging of endogenous NSCs in normal adult mice brains by using anti-CD15 antibody-conjugated superparamagnetic iron oxide nanoparticles (anti-CD15-SPIONs) as the molecular probe. Herein, we explore the performance of this molecular probe in targeted in vivo tracking...
Source: Molecules - August 28, 2016 Category: Chemistry Authors: Fang Zhang Xiaohui Duan Liejing Lu Xiang Zhang Xiaomei Zhong Jiaji Mao Meiwei Chen Jun Shen Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5783: Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model
ing-Hwa Liu An ischemic stroke is brain damage caused by interruption of blood supply to the brain that can cause death and long-term disability. New medical strategies or therapies are urgently needed for ischemic stroke. Icaritin (ICT) is a metabolite of icariin (ICA), which are two active flavonoid components extracted from Herba epimedii and considered neuroprotective agents in animal models of Alzheimer’s disease and ischemic stroke. The therapeutic effect of ICT on ischemic still remains to be clarified. The aim of this study was to investigate the therapeutic effect of ICT on cerebral ischemia-repe...
Source: Molecules - September 7, 2022 Category: Chemistry Authors: Cheng-Tien Wu Ting-Hua Yang Man-Chih Chen Siao-Syun Guan Chang-Mu Chen Shing-Hwa Liu Tags: Article Source Type: research

A new multi-parameter imaging platform for in vivo drug efficacy evaluation of ischemic stroke
Talanta. 2023 Aug 28;266(Pt 2):125133. doi: 10.1016/j.talanta.2023.125133. Online ahead of print.ABSTRACTIschemic stroke with high incidence and disability rate severely endangers human health. Current clinical treatment strategies are quite limited, new drugs for ischemic stroke are urgently needed. However, most existing methods for the efficacy evaluation of new drugs possess deficiencies of divorcing from the true biological context, single detection indicator and complex operations, leading to evaluation biases and delaying drug development process. In this work, leveraging the advantages of fluorescence imaging with ...
Source: Talanta - September 2, 2023 Category: Chemistry Authors: Di Su Ran Zhang Xin Wang Qi Ding Feida Che Wen Zhang Wei Wu Ping Li Bo Tang Source Type: research

Essential Hypertension, Cerebral White Matter Pathology And Ischemic Stroke.
Abstract Stroke is one of the most-frequent cause of death and the number one cause of disability worldwide. Different mechanisms are related to the pathogenesis of stroke involving multiple biological systems, which are often connected among them. Besides age, hypertension is the most important risk factor for stroke and may also predispose to the development of more subtle cerebral damage based on arteriolar narrowing or pathological microvascular changes. Age and high blood pressure are responsible for silent structural and functional cerebral changes leading to white matter lesions and cognitive impairment. Th...
Source: Current Medicinal Chemistry - December 27, 2013 Category: Chemistry Authors: Sierra C Tags: Curr Med Chem Source Type: research

Ischemic stroke and kynurenines: medicinal chemistry aspects.
Abstract Ischemic stroke is one of the leading causes of mortality and permanent disability in developed countries. Stroke induces massive glutamate release, which in turn causes N-Methyl-D-aspartate (NMDA) receptor over-excitation and thus calcium overload in neurons leading to cell death via apoptotic cascades. The kynurenine pathway is a complex enzymatic cascade of tryptophan catabolism, generating various neuroactive metabolites. One metabolite, kynurenic acid (KYNA), is a potent endogenous NMDA glutamate receptor antagonist, making it a possible therapeutic tool to decrease excitotoxicity and neuroinflammati...
Source: Current Medicinal Chemistry - March 12, 2018 Category: Chemistry Authors: Hertelendy P, Toldi J, Fulop F, Vecsei L Tags: Curr Med Chem Source Type: research

Molecules, Vol. 27, Pages 3099: The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke
This study aims to update and summarize the signaling pathways and targets of natural compounds in the treatment of IS, and provide a base of information for the future development of effective treatments for IS.
Source: Molecules - May 12, 2022 Category: Chemistry Authors: Xing-Hua Li Feng-Ting Yin Xiao-Hang Zhou Ai-Hua Zhang Hui Sun Guang-Li Yan Xi-Jun Wang Tags: Review Source Type: research