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Specialty: Neurology
Condition: Disability

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Total 4114 results found since Jan 2013.

Charting cognitive and volumetric trajectories after stroke: protocol for the Cognition And Neocortical Volume After Stroke (CANVAS) study
DiscussionMagnetic resonance imaging markers of structural brain aging and performance on neuropsychological tests are powerful predictors of dementia. We need to understand the trajectory of regional brain volume change and cognitive decline in patients after stroke. This will allow future risk stratification for prognostic counseling, service planning, and early therapeutic intervention.
Source: International Journal of Stroke - June 3, 2014 Category: Neurology Authors: Amy Brodtmann, Emilio Werden, Heath Pardoe, Qi Li, Graeme Jackson, Geoffrey Donnan, Tiffany Cowie, Jennifer Bradshaw, David Darby, Toby Cumming Tags: Protocols Source Type: research

A Literature Review of Indirect Costs Associated with Stroke
Conclusions: Most of the literature indicates that indirect costs account for a significant portion of the economic burden of stroke, and there is a pressing need to develop proper approaches to analyze these costs and to make better use of relevant data sources for such studies or establish new ones.
Source: Journal of Stroke and Cerebrovascular Diseases - June 23, 2014 Category: Neurology Authors: Heesoo Joo, Mary G. George, Jing Fang, Guijing Wang Tags: Review Articles Source Type: research

The Effects of Citicoline on Acute Ischemic Stroke: A Review
Early reopening of the occluded artery is, thus, important in ischemic stroke, and it has been calculated that 2 million neurons die every minute in an ischemic stroke if no effective therapy is given; therefore, “Time is Brain.” In massive hemispheric infarction and edema, surgical decompression lowers the risk of death or severe disability defined as a modified Rankin Scale score greater than 4 in selected patients. The majority, around 80%-85% of all ischemic stroke victims, does not fulfill the criteria for revascularization therapy, and also for these patients, there is no effective acute therapy. Also there is no...
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2014 Category: Neurology Authors: Karsten Overgaard Tags: Review Articles Source Type: research

Balancing access and quality in comprehensive stroke care
The establishment of stroke units and stroke centers has transformed the inpatient care of cerebrovascular disease and resulted in improved outcomes for patients hospitalized with stroke. Studies show that organized care as part of a stroke unit results in reduced mortality and disability after stroke,1 and that patients hospitalized at primary stroke centers have lower mortality and are more likely to receive thrombolytic therapy.2
Source: Neurology - March 23, 2015 Category: Neurology Authors: Kelly, A. G., Attia, J. Tags: All Health Services Research, Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, All epidemiology EDITORIALS Source Type: research

Ethnic Differences in Poststroke Quality of Life in the Brain Attack Surveillance in Corpus Christi (BASIC) Project Clinical Sciences
Conclusions— Disparities exist in poststroke QOL for MAs and seem to be driven by differences in older stroke patients. Targeted interventions to improve outcomes among MA stroke survivors are urgently needed.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Reeves, S. L., Brown, D. L., Baek, J., Wing, J. J., Morgenstern, L. B., Lisabeth, L. D. Tags: Behavioral/psychosocial - stroke Clinical Sciences Source Type: research

Statin therapy in acute ischemic stroke: Time for large randomized trials?
Despite improvements in stroke mortality coupled with therapeutic advances, stroke patients often face the prospect of substantial disability. Novel strategies are clearly needed to further improve stroke outcomes. These might include new indications for previously licensed drugs proven effective and safe in related disease processes,1 such as statins. Unlike strong evidence supporting statin use in cardiovascular risk reduction and acute myocardial ischemia, their effects on cerebral tissue and potential benefits on stroke outcomes remain poorly understood and understudied. The only current stroke-specific indication for ...
Source: Neurology - March 21, 2016 Category: Neurology Authors: Charidimou, A., Merwick, A. Tags: All Cerebrovascular disease/Stroke, Infarction EDITORIALS Source Type: research

Association of Hemoglobin A1c and Baseline Ischemic Stroke Severity: A Population-Based Study (P1.187)
Conclusions: We found that elevated HbA1c was associated with decreased stroke severity at presentation. However, this effect is mediated by the history of DM rather than a specific dose-effect of glycemic control. Our results provide evidence that although chronic hyperglycemia increases risk of stroke, it is not associated with increased stroke severity.Disclosure: Dr. Yang has nothing to disclose. Dr. Khoury has nothing to disclose. Dr. Alwell has nothing to disclose. Dr. Moomaw has received research support from the National Institutes of Health. Dr. Yeramaneni has nothing to disclose. Dr. Woo has received research sup...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Yang, Y., Khoury, J., Alwell, K., Moomaw, C., Yeramaneni, S., Woo, D., Flaherty, M., Adeoye, O., Ferioli, S., De Los Rios La Rosa, F., Kissela, B., Kleindorfer, D. Tags: Ischemic Stroke Outcomes Source Type: research

Frequency, determinants, and effects of early seizures after thrombolysis for acute ischemic stroke: The ENCHANTED trial
Conclusions: In thrombolysis-treated patients with acute ischemic stroke, seizures are uncommon, occur early, and predict poor recovery. Clinicaltrials.gov identifier: NCT01422616.
Source: Neurology Clinical Practice - August 14, 2017 Category: Neurology Authors: Xu, Y., Hackett, M. L., Chalmers, J., Lindley, R. I., Wang, X., Li, Q., Robinson, T., Arima, H., Lavados, P. M., Anderson, C. S., For the ENCHANTED Study Group Tags: Quality of life, All Cerebrovascular disease/Stroke, Prevalence studies, Infarction, All Epilepsy/Seizures Research Source Type: research

Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke
Conclusions: Higher serum MMP-9 levels in the acute phase of ischemic stroke were associated with increased risk of mortality and major disability, suggesting that serum MMP-9 could be an important prognostic factor for ischemic stroke.
Source: Neurology - August 21, 2017 Category: Neurology Authors: Zhong, C., Yang, J., Xu, T., Xu, T., Peng, Y., Wang, A., Wang, J., Peng, H., Li, Q., Ju, Z., Geng, D., Zhang, Y., He, J., For the CATIS Investigators Tags: Stroke prevention, Prognosis, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Cohort studies ARTICLE Source Type: research

Phosphodiesterase 10A Inhibition Leads to Brain Region-Specific Recovery Based on Stroke Type
AbstractStroke is the leading cause of adult disability. Recovery of function after stroke involves signaling events that are mediated by cAMP and cGMP pathways, such as axonal sprouting, neurogenesis, and synaptic plasticity. cAMP and cGMP are degraded by phosphodiesterases (PDEs), which are differentially expressed in brain regions. PDE10A is highly expressed in the basal ganglia/striatum. We tested a novel PDE10A inhibitor (TAK-063) for its effects on functional recovery. Stroke was produced in mice in the cortex or the striatum. Behavioral recovery was measured to 9  weeks. Tissue outcome measures included analysis of...
Source: Translational Stroke Research - May 5, 2020 Category: Neurology Source Type: research

Prevalence of Worsening Problems Using Post-Stroke Checklist and Associations with Quality of Life in Patients with Stroke
Stroke is the most common cause of adult disability worldwide.1,2 Stroke survivors suffer from various kinds of motor and non-motor problems, which hinders participation in daily activities.3,4 Without proper resolution of these problems, they can result in worsening of health-related quality of life (HRQoL).5 However, long-term post-stroke care has not been standardized yet,6 and stroke survivors have reported that health systems are not responsive to their changing needs.7 Therefore, long-term stroke follow-up should address a broad range of post-stroke medical and HRQoL –related problems with scheduled reassessments.
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Hyo Won Im, Won-Seok Kim, SeungYeun Kim, Nam-Jong Paik Source Type: research

Exploring dimensions of quality-of-life in survivors of stroke with communication disabilities - a brief report
CONCLUSIONS: Survivors of stroke with communication disabilities are more negatively impacted across different dimensions of quality-of-life (as reported between 90 and 180 days post-stroke) compared to those without communication disabilities. This highlights the need for timely and on-going comprehensive multidisciplinary person-centered support.PMID:35786371 | DOI:10.1080/10749357.2022.2095087
Source: Topics in Stroke Rehabilitation - July 5, 2022 Category: Neurology Authors: T Thayabaranathan C Baker N E Andrew R Stolwyk A G Thrift H Carter K Moss J Kim S J Wallace E Brogan R Grimley N A Lannin M L Rose D A Cadilhac Source Type: research