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Sarcopenia in acute ischemic stroke patients and patients with Parkinson ’s disease
Background: Sarcopenia is a condition characterized by a progressive generalized loss of skeletal muscle mass and strength. The most common nutritional problem that predisposes an ischemic stroke (IS) is sarcopenia. In patients with Parkinson's disease (PD), sarcopenia may represent the common downstream pathway that, from motor and non-motor symptoms leads to the progressive loss of resilience, frailty, and disability.
Source: Parkinsonism and Related Disorders - August 1, 2023 Category: Neurology Authors: S. Mandjikoska, G. Horvat Pinteri ć Source Type: research

The Effect of Branched Chain Amino Acid Supplementation on Stroke-Related Sarcopenia
ConclusionOur results showed a positive effect of BCAA supplementation on sarcopenia after stroke. We also found that nutritional support helps functional improvement during neurological recovery. These results suggest that comprehensive rehabilitation intervention combined with BCAA supplementation could be a helpful option during the critical period of post-stroke neurological recovery.
Source: Frontiers in Neurology - March 11, 2022 Category: Neurology Source Type: research

Premorbid frailty predicts short- and long-term outcomes of reperfusion treatment in acute stroke
DiscussionFrailty is an important predictor of efficacy of acute treatment of stroke beyond classical predictors of stroke outcomes. Larger longitudinal studies are, thus, warranted to evaluate the risk –benefit of reperfusion treatment in the growing elderly frail population.
Source: Journal of Neurology - January 17, 2022 Category: Neurology Source Type: research

End-of-Life Care Decision-Making in Stroke
Stroke is one of the leading causes of death and long-term disability in the United States. Though advances in interventions have improved patient survival after stroke, prognostication of long-term functional outcomes remains challenging, thereby complicating discussions of treatment goals. Stroke patients who require intensive care unit care often do not have the capacity themselves to participate in decision making processes, a fact that further complicates potential end-of-life care discussions after the immediate post-stroke period. Establishing clear, consistent communication with surrogates through shared decision-m...
Source: Frontiers in Neurology - September 28, 2021 Category: Neurology Source Type: research

What is the nutritional status of your patients suffering from strokes.
The objective of our study was to evaluate, through a questionnaire, the opinion of prescribing doctors working in the Department of Neurology of The FANN National Teaching Hospital in Dakar. The interest of the question resides in the fact that the Center does not have a dedicated nutritionist for inpatients. This was an opinion poll about their concerns about the nutritional status of patients in the therapeutic projects they propose during the stroke. The type of the chosen opinion poll was elementary, type random. The questionnaire was individual and consisted of five items of single-response and multiple-choice questi...
Source: Revue Neurologique - March 25, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice.
This study reveals a critical role for one‑carbon supplementation, with 5-methylTHF, vitamin B12, and choline, in supporting improvement after ischemic stroke damage. PMID: 31525435 [PubMed - as supplied by publisher]
Source: Neurobiology of Disease - September 12, 2019 Category: Neurology Authors: Jadavji NM, Mosnier H, Kelly E, Lawrence K, Cruickshank S, Stacey S, McCall A, Dhatt S, Arning E, Bottiglieri T, Smith PD Tags: Neurobiol Dis Source Type: research

A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke.
Abstract Stroke is a leading cause of disability and death world-wide and nutrition is a modifiable risk factor for stroke. Metheylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of folic acid, a B-vitamin. In humans, a polymorphism in MTHFR (677C→T) is linked to increased risk of stroke, but the mechanisms remain unknown. The Mthfr+/- mice mimic a phenotype described in humans at bp677. Using this mouse model, the aim of this study was to investigate the impact of MTHFR deficiency on stroke outcome. Male Mthfr+/- and wildtype littermate control mice were aged (~1.5-year-old) and tr...
Source: Experimental Neurology - July 25, 2018 Category: Neurology Authors: Jadavji NM, Emmerson JT, Shanmugalingam U, MacFarlane AJ, Willmore WG, Smith PD Tags: Exp Neurol Source Type: research