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Condition: Pregnancy
Drug: Melatonin
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Total 155 results found since Jan 2013.
Melatonin-pretreated HucMSCs improved endometrium regeneration and fertility recovery through macrophage immunomodulation in rats with intrauterine adhesions
This study aimed to investigate whether melatonin pretreatment enhances the efficacy of human umbilical cord mesenchymal stem cells (HucMSCs) in IUA treatment in rats. First, we explored the effect of melatonin on the biological activity of HucMSCs in vitro through a macrophage co-culture system, CCK-8, EdU, flow cytometry, immunofluorescence staining, and qRT-PCR. Subsequently, we established the IUA rat model and tracked the distribution of HucMSCs in this model. In addition, we observed the number of M1 and M2 macrophages through immunofluorescence staining and detected the levels of inflammatory cytokines. Four weeks a...
Source: Reproductive Biology - September 6, 2023 Category: Reproduction Medicine Authors: Weili Qin Jiawei Wang Qianwen Hu Rongyan Qin Nana Ma Fengque Zheng Wencai Tian Jinghang Jiang Ting Li Yufu Jin Ming Liao Aiping Qin Source Type: research
Differentiation of T cells producing interleukin-17 (Th17) against the background of exogenous melatonin during pregnancy
J Pineal Res. 2023 Aug 21:e12904. doi: 10.1111/jpi.12904. Online ahead of print.ABSTRACTThe population of T lymphocytes producing IL-17 (Th17) plays a dual role during pregnancy and its activity is tightly controlled during this period. One of the factors involved in this process may be the pineal hormone melatonin, which can effectively regulate this T cell population. Here we have shown that exogenous melatonin in pharmacological concentrations is able to enhance the differentiation of Th17 cells of pregnant women in vitro. The stimulatory effects of melatonin were limited to in the first trimester of pregnancy and were ...
Source: Cell Research - August 21, 2023 Category: Cytology Authors: Natalya Sergeevna Glebezdina Irina Valerievna Nekrasova Anna Alexandrovna Olina Gulnara Kamilyevna Sadykova Elena Michajlovna Kuklina Source Type: research
Melatonin associated with a high-fat diet during pregnancy and lactation prevents liver changes in the offspring
In conclusion, melatonin combined with a high-fat diet preserves the liver architecture and function in the offspring.PMID:37586542 | DOI:10.1016/j.ygcen.2023.114357
Source: General and Comparative Endocrinology - August 16, 2023 Category: Endocrinology Authors: Clovis J C Lapa Neto Ismaela M F de Melo Paloma K B M Alpiovezza Yuri M L de Albuquerque An ísio Francisco Soares Álvaro A C Teixeira Val éria Wanderley-Teixeira Source Type: research
Integration of nutrigenomics, melatonin, serotonin and inflammatory cytokines in the pathophysiology of pregnancy-specific urinary incontinence in women with gestational diabetes mellitus
Biochim Biophys Acta Mol Basis Dis. 2023 May 3:166737. doi: 10.1016/j.bbadis.2023.166737. Online ahead of print.ABSTRACTGestational diabetes mellitus is an important public health problem and has been associated with the development of pregnancy-specific urinary incontinence. The interaction is related to hyperglycemia, and inflammatory and hormonal patterns, which favor functional alterations in different organs and systems. Several genes associated with human diseases have been identified and partially characterized. Most of these genes are known to cause monogenic diseases. However, about 3 % of diseases do not fit the ...
Source: Biochimica et Biophysica Acta - May 5, 2023 Category: Biochemistry Authors: Danielle Cristina Honorio Fran ça Eduardo Luz ía França Luis Sobrevia Ang élica Mércia Pascon Barbosa Adenilda Cristina Honorio-Fran ça Marilza Vieira Cunha Rudge Diamater Study Group. Electronic address: diamaterstudy at gmail.com Source Type: research
Postnatal melatonin administration to stressed dams for ameliorating risk-taking behaviour in rat pups through maternal care improvement
CONCLUSION: It was concluded that prenatal restraint stress could impair stress responses and quality of maternal care, whereas postnatal melatonin administration potentially contributed to the normalization of stress reaction and anxiolysis.PMID:37114289 | DOI:10.1002/jdn.10265
Source: International Journal of Developmental Neuroscience - April 28, 2023 Category: Neuroscience Authors: Farzaneh Bagheri Iran Goudarzi Source Type: research
