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Specialty: Endocrinology
Condition: Pregnancy

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Total 24 results found since Jan 2013.

Periostin acts as a bridge between gestational diabetes mellitus (GDM) and chronic inflammation to modulate insulin resistance by modulating PPAR α/NF-κB/TNF-α signaling pathway
CONCLUSION: POSTN levels were significantly higher in pregnant women with GDM and were associated with chronic inflammation and PPARα expression. POSTN may act as a bridge between GDM and chronic inflammation to modulate insulin resistance by modulating PPARα/NF-κB/TNF-α signaling pathway.PMID:37106515 | DOI:10.2174/1871530323666230427104724
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 28, 2023 Category: Endocrinology Authors: Qun Ji Xinying Li Yan Wang Haiwei Liu Kaining Chen Huibiao Quan Huachuan Zhang Jianmin Ran Source Type: research

Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia
In this study, we determined Smad2 and Smad3 expression pattern in placenta and their effects on trophoblast invasion and differentiation. Total Smad2/3 levels were relatively constant across gestation while the ratio of active phosphorylated forms to their total levels varied with gestational stages, with a higher pSmad2/total Smad2 in later gestation and a higher pSmad3/total Smad3 in early gestation. Immunofluorescent staining revealed that pSmad3 was localized in nuclei of EVTs in anchoring villi. On the other hand, pSmad2 was mostly absent in this invasive EVT population. In addition, pSmad3/total Smad3, but not pSmad...
Source: Frontiers in Endocrinology - July 7, 2020 Category: Endocrinology Source Type: research

Oncostatin M stimulates cell migration and proliferation by down-regulating E-cadherin in HTR8/SVneo cell line through STAT3 activation
Conclusions: This study suggests that OSM stimulates the migration and proliferation of EVTs during the first trimester of pregnancy through the down-regulation of E-cadherin. In addition, this study suggests that the effects of OSM on migration and proliferation are related to STAT3 activation, which is important in trophoblast invasiveness.
Source: Reproductive Biology and Endocrinology - September 24, 2013 Category: Endocrinology Authors: Hyun KoSae ChoiHee KangHo KimJi JeonIn ParkJong Shin Source Type: research

Removal of Rev-erb{alpha} inhibition contributes to the prostaglandin G/H synthase 2 expression in rat endometrial stromal cells
This study focused on Ptgs2, which is essential for decidualization, as a putative clock-controlled gene, and aimed to reveal the functions of clock genes in relation to Ptgs2 during decidualization. We compared the transcript levels of clock genes in the rat uterus on days 4.5 (D4.5) and 6.5 of pregnancy. The transcript levels of clock genes (Per2, Bmal1, Rorα, and Rev-erbα) had decreased at implantation sites on day 6.5 (D6.5e) compared with those on D4.5, whereas Ptgs2 transcripts had increased on D6.5e. Similar observations of Rev-erbα and Ptgs2 were also obtained in the endometrium on D6.5e by immuno...
Source: AJP: Endocrinology and Metabolism - April 15, 2015 Category: Endocrinology Authors: Isayama, K., Zhao, L., Chen, H., Yamauchi, N., Shigeyoshi, Y., Hashimoto, S., Hattori, M.-a. Tags: Articles Source Type: research

Epidermal Growth Factor: Porcine Uterine Luminal Epithelial Cell Migratory Signal during the Peri-implantation Period of Pregnancy
Publication date: Available online 24 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Wooyoung Jeong, Seoungo Jung, Fuller W. Bazer, Gwonhwa Song, Jinyoung Kim The majority of early conceptus mortality in pregnancy occurs during the peri-implantation period, suggesting that this period is important for conceptus viability and the establishment of pregnancy. Successful establishment of pregnancy in all mammalian species depends on the orchestrated molecular events that transpire at the conceptus-uterine interface during the peri-implantation period of pregnancy. This maternal-conceptus interactio...
Source: Molecular and Cellular Endocrinology - November 24, 2015 Category: Endocrinology Source Type: research

Notch signaling plays a critical role in motility and differentiation of human first trimester cytotrophoblasts.
Abstract Failures in human extravillous trophoblast (EVT) development could be involved in the pathogenesis of pregnancy diseases. However, the underlying mechanisms have been poorly characterized. Here, we provide evidence that Notch signaling could represent a key regulatory pathway controlling trophoblast proliferation, motility and differentiation. Immunofluorescence of first trimester placental tissues revealed expression of Notch receptors (Notch2, Notch3) and membrane-anchored ligands (DLL1, 4 and JAG1, 2) in villous cytotrophoblasts (vCTBs), cell column trophoblasts (CCTs) and EVTs. Notch4 and Notch1 were ...
Source: Endocrinology - November 4, 2013 Category: Endocrinology Authors: Haider S, Meinhardt G, Velicky P, Otti GR, Whitley G, Fiala C, Pollheimer J, Knöfler M Tags: Endocrinology Source Type: research

EP2 Receptor Activates Dual G Protein Signaling Pathways that Mediate Contrasting Proinflammatory and Relaxatory Responses in Term Pregnant Human Myometrium.
Abstract Prostaglandin (PG) E2 (PGE2) plays a central role in the regulation of smooth muscle contractions. Classically, PGE2 stimulates contractions via EP1 and EP3 receptors, whereas EP2 and EP4 maintain quiescence. Labor involves a change from myometrial quiescence to contractions with a shift from anti- to proinflammatory pathways. EP2, a Gαs-coupled receptor, is known to mediate its actions via cAMP signaling. However, we have recently shown that EP2 also activates the proinflammatory PG G/H synthase-2 (PGHS-2). Here, we identify the mechanism underlying the ability of EP2 to maintain uterine quiescence and ...
Source: Endocrinology - November 21, 2013 Category: Endocrinology Authors: Kandola MK, Sykes L, Lee YS, Johnson MR, Hanyaloglu AC, Bennett PR Tags: Endocrinology Source Type: research

Prolonged Pregnancy in Women is Associated with Attenuated Myometrial Expression of Progesterone Receptor Co-Regulator Krüppel-like Factor 9.
Conclusions: Myometrial KLF9 may contribute to the onset of human parturition through its regulation of PGR expression and inflammatory signaling networks. PMID: 25313913 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 14, 2014 Category: Endocrinology Authors: Pabona JM, Zhang D, Ginsburg DS, Simmen FA, Simmen RC Tags: J Clin Endocrinol Metab Source Type: research

Endoplasmic reticulum stress regulates inflammation and insulin resistance in pregnant skeletal muscle
Publication date: Available online 20 February 2016 Source:Molecular and Cellular Endocrinology Author(s): Stella Liong, Martha Lappas Sterile inflammation and infection are key mediators of inflammation and peripheral insulin resistance associated with gestational diabetes mellitus (GDM). Studies have shown endoplasmic reticulum (ER) stress to induce inflammation and insulin resistance associated with obesity and type 2 diabetes, however is paucity of studies investigating the effects of ER stress in skeletal muscle on inflammation and insulin resistance associated with GDM. ER stress proteins IRE1α, GRP78 and XBP-1s...
Source: Molecular and Cellular Endocrinology - February 20, 2016 Category: Endocrinology Source Type: research

Endoplasmic reticulum stress regulates inflammation and insulin resistance in skeletal muscle from pregnant women
Publication date: 15 April 2016 Source:Molecular and Cellular Endocrinology, Volume 425 Author(s): Stella Liong, Martha Lappas Sterile inflammation and infection are key mediators of inflammation and peripheral insulin resistance associated with gestational diabetes mellitus (GDM). Studies have shown endoplasmic reticulum (ER) stress to induce inflammation and insulin resistance associated with obesity and type 2 diabetes, however is paucity of studies investigating the effects of ER stress in skeletal muscle on inflammation and insulin resistance associated with GDM. ER stress proteins IRE1α, GRP78 and XBP-1s were up...
Source: Molecular and Cellular Endocrinology - March 3, 2016 Category: Endocrinology Source Type: research

Cyclic AMP effectors regulate myometrial oxytocin receptor expression.
Abstract The factors that initiate human labor are poorly understood. We have tested the hypothesis that a decline in cAMP/PKA function leads to the onset of labor. Initially, we identified myometrial cAMP/PKA responsive genes (6 up-regulated and 5 down-regulated genes) and assessed their expression in myometrial samples taken from different stages of pregnancy and labor. We found that the oxytocin receptor (OTR) was one of the cAMP repressed genes and, given the importance of OTR in the labor process, we studied the mechanisms involved in greater detail using siRNA, chemical agonists and antagonists of the cAMP e...
Source: Endocrinology - September 26, 2016 Category: Endocrinology Authors: Yulia A, Singh N, Lei K, Sooranna SR, Johnson MR Tags: Endocrinology Source Type: research

Maternal 25 ‐hydroxyvitamin D is inversely correlated with fetal serotonin
ConclusionsThese observations provide the first evidence of an inverse relationship between maternal 25(OH)D and fetal serotonin concentrations. We propose that maternal vitamin D deficiency increases fetal serotonin concentrations and thereby contributes to longer‐term neurocognitive impairment in infants and children.This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - October 31, 2016 Category: Endocrinology Authors: Padma Murthi, Miranda Davies ‐Tuck, Martha Lappas, Harmeet Singh, Joanne Mockler, Rahana Rahman, Rebecca Lim, Bryan Leaw, James Doery, Euan M Wallace, Peter R Ebeling Tags: Original Article Source Type: research