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Specialty: Internal Medicine
Condition: Atrial Fibrillation

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Total 509 results found since Jan 2013.

Stroke prophylaxis in high-risk patients with atrial fibrillation: Rhythm vs. rate control strategy.
CONCLUSIONS: Anti-thrombotic prophylaxis in CHADS₂ ≥2 patients is different in subjects assigned to the Rhythm vs. the Rate control strategy, as well as reported reasons for warfarin non use. GPs do not know why warfarin is not used in a large percentage of cases, mainly in the rhythm control strategy group. Improving efforts should probably be differently tailored for patients assigned to the "rhythm" or the "rate" control strategy. PMID: 23474251 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - March 5, 2013 Category: Internal Medicine Authors: Filippi A, Zoni-Berisso M, Ermini G, Landolina M, Brignoli O, D'Ambrosio G, Zingarini G, Pedrinazzi C Tags: Eur J Intern Med Source Type: research

Do NOACs Improve Antithrombotic Therapy in Secondary Stroke Prevention in Nonvalvular Atrial Fibrillation?
Abstract: Guidelines recommended oral anticoagulant (OAC) for ischemic stroke patients related to atrial fibrillation (AF). But, underprescription or underdose of warfarin was observed worldwide. We aimed to explore if the use of antithrombotic therapy in nonvalvular AF (NVAF) ischemic stroke patients improved after novel oral anticoagulants (NOACs) became available. Between January 2011 to December 2013, 360 acute ischemic stroke patients related to NVAF were recruited. Patients were categorized into 2 groups based on the date (July 2012) of NOACs’ availability. There were 184 patients recruited before July 2012, and wh...
Source: Medicine - September 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

The ABC-stroke risk score was superior to the CHA2DS2-VASc score for predicting stroke in atrial fibrillation.
PMID: 27323265 [PubMed - in process]
Source: Annals of Internal Medicine - June 20, 2016 Category: Internal Medicine Authors: Hankey GJ Tags: Ann Intern Med Source Type: research

Guideline-adherent therapy for stroke prevention in atrial fibrillation in different health care settings: Results from RAMSES study.
CONCLUSION: This study demonstrates the marked disparity between patient groups with AF presenting at SHs and THs. The use of guideline-recommended therapy is not adequate in either type of centre, overtreatment was more prevalent in THs and undertreatment was more prevalent in SHs. PMID: 28238569 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - February 22, 2017 Category: Internal Medicine Authors: Başaran Ö, Dogan V, Biteker M, Karadeniz FÖ, Tekkesin Aİ, Çakıllı Y, Türkkan C, Hamidi M, Demir V, Gürsoy MO, Öztürk MT, Aksan G, Seyis S, Ballı M, Alıcı MH, Bozyel S, Kırma C, Collaborators Tags: Eur J Intern Med Source Type: research

Standard and reduced doses of dabigatran, rivaroxaban, and apixaban for stroke prevention in atrial fibrillation: a nationwide cohort study
ConclusionsStandard and reduced dose NOACs, respectively, showed no significant risk difference for associated stroke/thromboembolism. Rivaroxaban was associated with higher bleeding risk compared with dabigatran and apixaban, and dabigatran was associated with lower intracranial bleeding risk compared with rivaroxaban and apixaban.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 1, 2017 Category: Internal Medicine Authors: Laila Staerk, Thomas A Gerds, Gregory Y H Lip, Brice Ozenne, Anders N Bonde, Morten Lamberts, Emil L Fosb øl, Christian Torp‐Pedersen, Gunnar H Gislason, Jonas B Olesen Tags: Original Article Source Type: research

Standard and reduced doses of dabigatran, rivaroxaban and apixaban for stroke prevention in atrial fibrillation: a nationwide cohort study
ConclusionsStandard and reduced dose NOACs, respectively, showed no significant risk difference for associated stroke/thromboembolism. Rivaroxaban was associated with higher bleeding risk compared with dabigatran and apixaban and dabigatran was associated with lower intracranial bleeding risk compared with rivaroxaban and apixaban.
Source: Journal of Internal Medicine - September 21, 2017 Category: Internal Medicine Authors: L. Staerk, T. A. Gerds, G. Y. H. Lip, B. Ozenne, A. N. Bonde, M. Lamberts, E. L. Fosb øl, C. Torp‐Pedersen, G. H. Gislason, J. B. Olesen Tags: Original Article Source Type: research

Antiplatelet therapy combined with acenocoumarol in relation to major bleeding, ischaemic stroke and mortality
ConclusionsIn AF patients, the risk of bleeding is higher when antiplatelet therapy is combined with acenocoumarol, but the risk of mortality and stroke was not significantly different from that of patients taking only acenocoumarol.
Source: International Journal of Clinical Practice - February 12, 2018 Category: Internal Medicine Authors: Jos é Miguel Rivera‐Caravaca, Francisco Marín, María Asunción Esteve‐Pastor, Mariano Valdés, Vicente Vicente, Vanessa Roldán, Gregory Y.H. Lip Tags: SHORT REPORT Source Type: research

Twenty‐eight day Holter monitoring is poorly tolerated and insensitive for paroxysmal atrial fibrillation detection in cryptogenic stroke
Abstract This pilot study in a prospective cohort of 20 cryptogenic stroke patients showed that a significant proportion has paroxysmal atrial fibrillation undetected by 24‐h Holter monitoring. However, longer monitoring with 28‐day Holter was poorly tolerated and still insufficiently sensitive for paroxysmal atrial fibrillation detection. Further studies are urgently needed to elucidate the optimal timing, method and duration of cardiac rhythm monitoring following ischaemic stroke.
Source: Internal Medicine Journal - May 12, 2014 Category: Internal Medicine Authors: H. T. Tu, S. Spence, J. M. Kalman, S. M. Davis Tags: Brief Communications Source Type: research

Antithrombotic use following transient ischaemic attack or ischaemic stroke among older Australians with atrial fibrillation
Abstract Hospital audits may underestimate anticoagulant use among acute ischaemic stroke patients with atrial fibrillation (AF), as treatment may commence after discharge. To account for this, antithrombotic use in the 4 months after hospitalisation for transient ischaemic attack or ischaemic stroke among AF patients was assessed using claims data. Results suggest that treatment may be commenced soon after discharge and should be considered when assessing prevalence of use.
Source: Internal Medicine Journal - November 4, 2014 Category: Internal Medicine Authors: J. K. Sluggett, G. E. Caughey, M. B. Ward, A. L. Gilbert Tags: Brief Communications Source Type: research

Increased Risk of First-Ever Stroke in Younger Patients With Atrial Fibrillation Not Recommended for Antithrombotic Therapy by Current Guidelines: A Population-Based Study in an East Asian Cohort of 22 Million People
To assess the risk of first-ever ischemic stroke in younger patients with atrial fibrillation (AF) who have none of the CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, previous stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category [female sex]) risk factors (excluding female sex) by using the National Health Insurance research database in Taiwan.
Source: Mayo Clinic Proceedings - November 1, 2014 Category: Internal Medicine Authors: Kuan-Cheng Chang, Yu-Chen Wang, Po-Yen Ko, Hung-Pin Wu, Yu-Wei Chen, Chih-Hsin Muo, Fung-Chang Sung, Tsai-Chung Li, Chung Y. Hsu Tags: Original article Source Type: research

NSAIDs increase bleeding risk in patients with atrial fibrillation on antithrombotic therapy
This study determined the risk...
Source: Evidence-Based Medicine - September 24, 2015 Category: Internal Medicine Authors: McGrath, E. R. Tags: Epidemiologic studies, Drugs: cardiovascular system, Stroke, Ischaemic heart disease, Drugs: musculoskeletal and joint diseases, Arrhythmias Aetiology/Harm Source Type: research

The adoption of direct oral anticoagulants for stroke prevention in atrial fibrillation
ConclusionDOACs prescribing grew rapidly from 2013 to 2014, regionally and nationally. Warfarin prescriptions have remained stable, indicating that more patients are being appropriately anticoagulated for atrial fibrillation that previously were not. DOACs were found to be prescribed to patients with lower CHA2DS2VASc and HASBLED scores, younger age, and higher GFR. Aspirin therapy remains over utilised in AF.
Source: Internal Medicine Journal - April 3, 2016 Category: Internal Medicine Authors: David Baker, Bradley Wilsmore, Seshasayee Narasimhan Tags: Original Article Source Type: research

Adoption of direct oral anticoagulants for stroke prevention in atrial fibrillation
Conclusion DOAC prescribing grew rapidly from 2013 to 2014, regionally and nationally. Warfarin prescriptions have remained stable, indicating that more patients are being appropriately anticoagulated for AF who previously were not. DOAC were found to be prescribed to patients with lower CHA2DS2VASc and HAS‐BLED scores, younger age and higher glomerular filtration rates. Aspirin therapy remains over utilised in AF.
Source: Internal Medicine Journal - July 11, 2016 Category: Internal Medicine Authors: D. Baker, B. Wilsmore, S. Narasimhan Tags: Original Article Source Type: research

Global longitudinal strain predicts incident atrial fibrillation and stroke occurrence after acute myocardial infarction
Abstract: Patients with acute myocardial infarction are at increased risk of developing atrial fibrillation. We aimed to evaluate whether speckle tracking echocardiography improves risk stratification for atrial fibrillation in these patients. The study comprised of 373 patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention. Patients had an echocardiogram performed at a median of 2 days after their STEMI. The echocardiograms consisted of conventional measurements and myocardial strain analysis by speckle tracking from 3 apical projections. The endpoint was ...
Source: Medicine - November 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Resumption of anticoagulation after major bleeding decreases the risk of stroke in patients with atrial fibrillation
This study aimed to (1) evaluate anticoagulation use after a major bleeding event on dabigatran or warfarin and (2) compare outcomes between patients discontinuing anticoagulation and those restarting dabigatran or warfarin. Methods This was...
Source: Evidence-Based Medicine - June 9, 2017 Category: Internal Medicine Authors: Smit, M. D., Van Gelder, I. C. Tags: Therapeutics/Prevention Source Type: research