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Self-reported adherence to direct oral anticoagulants versus warfarin therapy in a specialized thrombosis service —a cross-sectional study of patients in a Canadian Health Region
ConclusionsSelf-reported medication adherence was similar between warfarin and DOACs. Since suboptimal adherence is associated with poor clinical outcomes and increased costs, various stakeholders should emphasize the importance of medication adherence to oral anticoagulants at each patient encounter.
Source: European Journal of Clinical Pharmacology - November 18, 2022 Category: Drugs & Pharmacology Source Type: research

Comparative Effectiveness and Safety of Low-Dose Oral Anticoagulants in Patients With Atrial Fibrillation
Conclusions: The results of this population-based study suggest that low-dose dabigatran has a better effective composite than warfarin. Compared with apixaban, low-dose dabigatran had a better effectiveness composite but a worse safety profile. Low-dose apixaban had a better safety composite than warfarin and other low-dose DOACs. Given that the comparative effectiveness and safety seem to vary from one DOAC to another, pharmacokinetic data for specific populations are now warranted.
Source: Frontiers in Pharmacology - January 14, 2022 Category: Drugs & Pharmacology Source Type: research

Warfarin adherence and anticoagulation control in atrial fibrillation patients: a systematic review
CONCLUSIONS: While the available evidence is limited, this systematic review demonstrated a positive finding of the association between warfarin adherence and anticoagulation control in patients with AF.PMID:34982455 | DOI:10.26355/eurrev_202112_27642
Source: European Review for Medical and Pharmacological Sciences - January 4, 2022 Category: Drugs & Pharmacology Authors: M Ababneh S A Nasser A Rababa'h F Ababneh Source Type: research

Regulatory Role of Cardiomyocyte Metabolism via AMPK Activation in Modulating Atrial Structural, Contractile, and Electrical Properties Following Atrial Fibrillation.
Abstract Patients diagnosed with atrial fibrillation (AF) have been rising due to increased incidence, enhanced detection methods, and greater survival rates following diagnosis. Due to this increase, AF is now the most commonly diagnosed arrhythmia in clinical practice. AF is characterized by irregular, high-frequency contractions of atrial myocytes that lead to turbulent blood flow and the potential for thrombus formation, stroke, or heart failure. These high-frequency contractions of the atrial myocytes cause an imbalance between metabolic supply and demand. Although advances have been made in understanding the...
Source: Canadian Journal of Physiology and Pharmacology - October 13, 2020 Category: Drugs & Pharmacology Authors: Brown SM, Larsen NK, Thankam FG, Agrawal DK Tags: Can J Physiol Pharmacol Source Type: research

Antiarrhythmic and cardiac electrophysiological effects of SZV-270, a novel compound with combined Class I/B and Class III effects, in rabbits and dogs.
In conclusion, SZV-270 with its combined Class I/B and III effects can prevent re-entry arrhythmias with reduced risk of provoking drug-induced Torsades de Pointes. PMID: 32970956 [PubMed - as supplied by publisher]
Source: Canadian Journal of Physiology and Pharmacology - September 23, 2020 Category: Drugs & Pharmacology Authors: Varga RS, Hornyik T, Husti Z, Kohajda Z, Krajsovszky G, Nagy N, Jost N, Virág L, Tálosi L, Mátyus P, Varró A, Baczkó I Tags: Can J Physiol Pharmacol Source Type: research

Descriptive analysis of pharmacy services provided after community pharmacy screening
Conclusions Approximately one-third of participants received a pharmacy service within 3  months post-screening. Relatively large numbers of annual and follow-up medication reviews were delivered despite low eligibility for annual-only reviews and despite many missed opportunities for pharmacy service provision in at-risk patients. In-pharmacy screening may facilitate provision of some services, namely medication reviews, by providing opportunities to identify patients at-risk.
Source: International Journal of Clinical Pharmacy - November 26, 2018 Category: Drugs & Pharmacology Source Type: research