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Specialty: Cardiology
Condition: Aortic Stenosis

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Total 670 results found since Jan 2013.

Impact of Aortic Valve Replacement on Outcome of Symptomatic Patients with Severe Aortic Stenosis with Low Gradient and Preserved Left Ventricular Ejection Fraction.
CONCLUSIONS: AVR is associated with better survival than medical therapy in patients with symptomatic low gradient severe AS and preserved LVEF. PMID: 23812184 [PubMed - as supplied by publisher]
Source: Circulation - June 27, 2013 Category: Cardiology Authors: Ozkan A, Hachamovitch R, Kapadia SR, Tuzcu EM, Marwick TH Tags: Circulation Source Type: research

Transcatheter Aortic Valve Replacement in Nonsurgical Candidates With Severe, Symptomatic Aortic Stenosis: A Cost-Effectiveness Analysis Original Articles
Conclusions— TAVR seems to be an effective but somewhat expensive alternative to medical management among patients with symptomatic aortic stenosis ineligible for surgery. TAVR is more cost-effective for patients with a lower burden of noncardiac disease.
Source: Circulation: Cardiovascular Quality and Outcomes - July 16, 2013 Category: Cardiology Authors: Simons, C. T., Cipriano, L. E., Shah, R. U., Garber, A. M., Owens, D. K., Hlatky, M. A. Tags: Health policy and outcome research Original Articles Source Type: research

Early and mid-term cardiovascular outcomes following TAVI: Impact of pre-procedural transvalvular gradient
Abstract: Objective: To assess the relation of aortic transvalvular gradient with outcomes following transcatheter aortic valve implantation (TAVI).Background: Relatively little is known about the predictors of adverse outcomes in patients with severe aortic stenosis following TAVI.Methods: We studied 126 consecutive patients (mean age 83.2±6.3years; 59% women) who underwent TAVI (23% transapical; 77% transfemoral) at our institution. All patients were followed for the incidence of major adverse cardiovascular events (MACE), including myocardial infarction, heart failure, stroke, and cardiovascular death.Results: The acut...
Source: International Journal of Cardiology - March 29, 2012 Category: Cardiology Authors: Nicolas Amabile, Ramzi Ramadan, Said Ghostine, Susan Cheng, Alexandre Azmoun, François Raoux, Ngoc-Tram To, Yacine Haddouche, Xavier Troussier, Remi Nottin, Christophe Caussin Tags: Original Articles Source Type: research

Impact of Low Flow on the Outcome of High-Risk Patients Undergoing Transcatheter Aortic Valve Replacement
This study sought to assess the impact of baseline left ventricular (LV) outflow, LV ejection fraction (LVEF), and transvalvular gradient on outcomes following transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis (AS).BackgroundLow flow (i.e., reduced stroke volume index [SVi]) can occur with both reduced and preserved LVEF. Low flow is often associated with low gradient despite severe stenosis and with worse outcomes following surgical aortic valve replacement. However, there are few data about the impact of low flow on outcomes following TAVR.MethodsWe retrospectively analyzed the clinica...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - August 19, 2013 Category: Cardiology Source Type: research

Systemic Hypertension in Low Gradient Severe Aortic Stenosis with Preserved Ejection Fraction.
CONCLUSIONS: Systemic hypertension in LG severe AS with preserved EF is associated with elevated LV filling pressures and pulmonary hypertension. Treatment of hypertension with vasodilator therapy results in a lowering of the total LV afterload, with a decrease in LV filling pressures and pulmonary artery pressures. These findings have important implications for the management of patients with LG severe AS with preserved EF and hypertension. PMID: 23956211 [PubMed - as supplied by publisher]
Source: Circulation - August 16, 2013 Category: Cardiology Authors: Eleid MF, Nishimura RA, Sorajja P, Borlaug BA Tags: Circulation Source Type: research

Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis: Results from an intermediate risk propensity-matched population of the Italian OBSERVANT study
Conclusions: Patients undergoing transcatheter and surgical treatment of severe aortic stenosis are still extremely distinct populations. In the relatively low-risk propensity-matched population analyzed, despite similar procedural and 30-day mortality, SAVR was associated with a higher risk for blood transfusion, whereas TAVI showed a significantly increased rate of vascular damage, permanent AV block and residual aortic valve regurgitation.
Source: International Journal of Cardiology - May 28, 2012 Category: Cardiology Authors: Paola D'Errigo, Marco Barbanti, Marco Ranucci, Francesco Onorati, Remo Daniel Covello, Stefano Rosato, Corrado Tamburino, Francesco Santini, Gennaro Santoro, Fulvia Seccareccia, on behalf of the OBSERVANT Research Group Tags: Original Articles Source Type: research

A Meta-Analysis of Mortality and Major Adverse Cardiovascular and Cerebrovascular Events Following Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement for Severe Aortic Stenosis
The purpose of this meta-analysis was to compare postprocedural mortality and major adverse cardiovascular and cerebrovascular events between transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) for severe aortic stenosis. Seventeen studies (n = 4,659) comparing TAVI (n = 2,267) and SAVR (n = 2,392) were included. End points were baseline logistic European System for Cardiac Operative Risk Evaluation score, all-cause mortality, cardiovascular mortality, myocardial infarction, stroke, transient ischemic attack, and major bleeding events. Mean differences or risk ratios with 95% conf...
Source: The American Journal of Cardiology - June 6, 2013 Category: Cardiology Authors: Hemang B. Panchal, Vatsal Ladia, Saurabh Desai, Tejaskumar Shah, Vijay Ramu Tags: Valvular Heart Disease Source Type: research

Comparison of multicenter registries and randomized control trials for transcatheter aortic valve replacement (TAVR).
CONCLUSIONS: Short-term results in PARTNER were better than those reported in the registries, which may be due to better patient selection and aggressive bailout techniques. Similarity of medium-term outcomes between registries and PARTNER highlights that patient selection for TAVR is critical due to considerable risk of mortality in the first year even after the successful procedure. PMID: 23993001 [PubMed - in process]
Source: Indian Heart J - July 1, 2013 Category: Cardiology Authors: Agarwal S, Tuzcu EM, Stewart W, Bajaj NS, Svensson LG, Kapadia SR Tags: Indian Heart J Source Type: research

A Meta-Analysis of Mortality and Major Adverse Cardiovascular and Cerebrovascular Events Following Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement for Severe Aortic Stenosis
The purpose of this meta-analysis was to compare postprocedural mortality and major adverse cardiovascular and cerebrovascular events between transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) for severe aortic stenosis. Seventeen studies (n = 4,659) comparing TAVI (n = 2,267) and SAVR (n = 2,392) were included. End points were baseline logistic European System for Cardiac Operative Risk Evaluation score, all-cause mortality, cardiovascular mortality, myocardial infarction, stroke, transient ischemic attack, and major bleeding events. Mean differences or risk ratios with 95% conf...
Source: The American Journal of Cardiology - June 6, 2013 Category: Cardiology Authors: Hemang B. Panchal, Vatsal Ladia, Saurabh Desai, Tejaskumar Shah, Vijay Ramu Tags: Valvular Heart Disease Source Type: research

Invasive Hemodynamic Assessment of “Paradoxical” Low-Flow Severe Aortic Stenosis
We read with interest the paper by Lauten et al. (1) discussing the invasive hemodynamic characteristics of low-gradient, severe aortic stenosis (AS) despite preserved ejection fraction. The authors' main finding was that low-gradient, severe AS despite preserved ejection fraction was not merely the result of a systematic bias in the echocardiographic calculation of the aortic valve area (AVA) as a result of measurement error and so forth, but was in fact a real entity as confirmed by invasively derived hemodynamic data using both the thermodilution and the oxygen consumption methods for stroke volume, cardiac output, and...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - October 7, 2013 Category: Cardiology Source Type: research

Impact of global hemodynamic load on exercise capacity in aortic stenosis
Abstract: Background: The determinants of maximal exercise capacity (MEC) in aortic stenosis (AS) are, in large part, unknown. We hypothesized that the left ventricular (LV) global hemodynamic load – as assessed by the valvulo-arterial impedance (Zva) – is one of the main determinants of MEC and we sought to evaluate the factors associated with reduced MEC in AS.Method and results: Asymptomatic patients with moderate or severe AS (n=62, aortic valve area 50%) were prospectively referred for comprehensive resting echocardiography and cardiopulmonary exercise test. Absolute peak VO2 was 19.5±5.7mL/kg/min (median 19.6mL/...
Source: International Journal of Cardiology - March 1, 2013 Category: Cardiology Authors: R. Dulgheru, J. Magne, R. Capoulade, L. Davin, D. Vinereanu, L.A. Pierard, P. Pibarot, P. Lancellotti Tags: Original Articles Source Type: research

MSCT guided sizing of the Edwards Sapien XT TAVI device: Impact of different degrees of oversizing on clinical outcome
Abstract: Aims: Prospective data on the usage of 3-dimensional imaging based annulus sizing on the outcome of TAVI is not available yet and there is general uncertainty about the optimal degree of oversizing. In the current study we therefore assessed a 3-D MSCT guided over-sizing approach and evaluated the clinical outcome of different degrees of oversizing.Methods: TAVI-size-selection was done using systolic MSCT-annulus cross-sectional-area (CSA) measurements in 107 patients with severe aortic stenosis with the goal to oversize the 3rd generation balloon expandable Edwards Sapien XT (ESTV) device in relation to the nati...
Source: International Journal of Cardiology - April 15, 2013 Category: Cardiology Authors: A.W. Leber, W. Eichinger, J. Rieber, M. Lieber, S. Schleger, U. Ebersberger, M. Deichstetter, J. Vogel, T. Helmberger, D. Antoni, G. Riess, E. Hoffmann, A.M. Kasel Tags: Original Articles Source Type: research

Prognostic Value of Coronary Flow Reserve in Asymptomatic Moderate or Severe Aortic Stenosis with Preserved Ejection Fraction and Nonobstructed Coronary Arteries
Conclusion: This study demonstrates that CFR has a prognostic value in patients with asymptomatic moderate or severe AS with preserved EF and nonobstructed coronary arteries.
Source: Echocardiography - October 24, 2013 Category: Cardiology Authors: Banovic Marko, Vujisic‐Tesic Bosiljka, Brkovic Voin, Petrovic Milan, Nedeljkovic Ivana, Popovic Dejana, Trifunovic Danijela, Nikolic Serjan Tags: Original Investigation Source Type: research