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Direct Oral Anticoagulants in Patients on Chronic Dialysis and Concomitant Atrial Fibrillation: A Common Clinical Impasse
Front Biosci (Schol Ed). 2022 Jul 21;14(3):21. doi: 10.31083/j.fbs1403021.ABSTRACTThe most frequent arrhythmia treated is atrial fibrillation (AF), which necessitates the use of oral anticoagulants (OACs) to reduce the risk of thromboembolism and stroke. Patients with chronic kidney disease are more likely to develop AF, with a 10% frequency among those on chronic dialysis. Warfarin is the most widely prescribed OAC for individuals with end-stage kidney disease (ESKD). On the other hand, direct OACs (DOACs) are generally safer than warfarin, with fewer fatal bleeding events and a fixed dose that does not require close inte...
Source: Frontiers in Bioscience - Scholar - September 22, 2022 Category: Biomedical Science Authors: Nikolaos Ktenopoulos Marios Sagris Panagiotis Theofilis Sophia Lionaki Loukianos S Rallidis Source Type: research

Risk of peripheral artery disease and stroke in migraineurs with or without aura: a nationwide population-based cohort study
Conclusion: Migraineurs without established cardiovascular disease had a significantly increased risk of PAD and stroke, and the risk of stroke persists in migraineurs with or without aura, with an increased trend of PAD in migraineurs with aura. Our study result should remind clinical physicians of the risk of PAD in the future among migraineurs even without established cardiovascular disease currently, and screening for PAD and stroke may be needed in caring patients with migraine.PMID:35919822 | PMC:PMC9339415 | DOI:10.7150/ijms.72119
Source: International Journal of Medical Sciences - August 3, 2022 Category: Biomedical Science Authors: Wun-Zhih Siao Chun-Hung Su Yu-Hsiang Kuan Tung-Han Tsai Kuang-Hua Huan Chien-Ying Lee Source Type: research

A clinically relevant model of focal embolic cerebral ischemia by thrombus and thrombolysis in rhesus monkeys
Nature Protocols, Published online: 27 June 2022; doi:10.1038/s41596-022-00707-5Treatments developed in small-animal models of stroke are often not translatable to the clinic. In this protocol, a blood clot in a microcatheter is introduced into the middle cerebral artery of rhesus monkeys; controlled thrombolysis is possible.
Source: Nature Protocols - June 27, 2022 Category: Biomedical Science Authors: Di Wu Jian Chen Longfei Wu Hangil Lee Jingfei Shi Mo Zhang Yanhui Ma Xiaoduo He Zixin Zhu Feng Yan Chuanjie Wu Yunxia Duan Yongjuan Fu Sijie Li Xinglong Zhi Xuxiang Zhang Shengli Li Yuchuan Ding Xunming Ji Source Type: research

Association between plaque vulnerability and neutrophil extracellular traps (NETs) levels: The Plaque At RISK study
In conclusion, plaque vulnerability is positively associated with plasma levels of NETs, but only in patients naive to statins or antithrombotic medication prior to the index event.
Source: PLoS One - June 9, 2022 Category: Biomedical Science Authors: Judith J. de Vries Source Type: research

Evaluation of thrombophilia testing in the inpatient setting: A single institution retrospective review
ConclusionOur study revealed that a majority of inpatient thrombophilia testing did not follow institutional guidelines for appropriate testing and did not change patient management. These thrombophilia tests are often overutilized and have minimal clinical utility in the inpatient setting.
Source: PLoS One - September 20, 2021 Category: Biomedical Science Authors: Chun Ting Siu Source Type: research

Computational research of mTORC1 inhibitor on cerebral ischemia-reperfusion injury
Aging (Albany NY). 2021 Aug 3;13(undefined). doi: 10.18632/aging.203371. Online ahead of print.ABSTRACTIschemic stroke contributes to more than 80% of all strokes and has the four characteristics of high prevalence, high disability, high mortality, and high recurrence. Stroke is a preventable and controllable disease. In addition to controlling the primary disease, effective prevention and control measures need to be given to the occurrence and development of stroke. With the development and progress of modern treatment methods for ischemic stroke, the mortality and disability rate have decreased significantly. At present,...
Source: Aging - August 3, 2021 Category: Biomedical Science Authors: Hui Li Wenzhuo Yang Zhenhua Wang Xu Wang Yulei Hao Jianxin Xi Han Lu Zhishan Du Jiachun Feng Bao Zhang Di Ma Source Type: research

Therapeutic efficacy of direct oral anticoagulants and vitamin K antagonists for left ventricular thrombus: Systematic review and meta-analysis
ConclusionsEfficacy and adverse outcomes of therapy with DOACs and VKAs do not differ. Randomized controlled trials are needed to determine the optimal anticoagulant strategy.
Source: PLoS One - July 26, 2021 Category: Biomedical Science Authors: Tetsuji Kitano Source Type: research

Decreased clot burden is associated with factor XIII Val34Leu polymorphism and better functional outcomes in acute ischemic stroke patients treated with intravenous thrombolysis
ConclusionsCBS was found to be a significant independent predictor of thrombolysis outcomes. FXIII-A Leu34 carrier status was associated with smaller thrombus burden, which is consistent with thein vitro described whole blood clot mass reducing effects of the allele, but the polymorphism had no effect on thrombolysis outcomes.
Source: PLoS One - July 7, 2021 Category: Biomedical Science Authors: Istv án Szegedi Source Type: research

Demonstration of proof-of-concept of < i > StrokeShield < /i > system for complete closure and occlusion of the left atrial appendage for non-valvular atrial fibrillation therapy
by Mark S. Slaughter, Gretel Monreal, Steven C. Koenig, Guruprasad A. Giridharan, Landon H. Tompkins, Jorge H. Jimenez In the US, the most significant morbidity and mortality associated with non-valvular atrial fibrillation (NVAF) is embolic stroke, with 90% of thrombus originating from the left atrial appendage (LAA). Anticoagulation is the preferred treatment for the prevention of stroke in NVAF patients, but cl inical studies have demonstrated high levels of non-compliance and increased risk of bleeding or ineligibility for anticoagulation therapy, especially in the elderly population where the incidence of NVAF is hig...
Source: PLoS One - June 22, 2021 Category: Biomedical Science Authors: Mark S. Slaughter Source Type: research

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