A clinically relevant model of focal embolic cerebral ischemia by thrombus and thrombolysis in rhesus monkeys

Nature Protocols, Published online: 27 June 2022; doi:10.1038/s41596-022-00707-5Treatments developed in small-animal models of stroke are often not translatable to the clinic. In this protocol, a blood clot in a microcatheter is introduced into the middle cerebral artery of rhesus monkeys; controlled thrombolysis is possible.

Source: Nature Protocols - June 27, 2022 Category: Biomedical Science Authors: Di Wu Jian Chen Longfei Wu Hangil Lee Jingfei Shi Mo Zhang Yanhui Ma Xiaoduo He Zixin Zhu Feng Yan Chuanjie Wu Yunxia Duan Yongjuan Fu Sijie Li Xinglong Zhi Xuxiang Zhang Shengli Li Yuchuan Ding Xunming Ji Source Type: research