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Oxidative Modified Fibrinogen in Cardiovascular Diseases
ConclusionsThe results show that the degree of impairment of fibrinogen functions in the cardiovascular diseases is related to the level of oxidative stress. Characterization of oxidative fibrinogen modification and its precise meaning to the function of fibrinogen in hemostasis appears to be extremely helpful to better understanding of thrombotic/bleeding complications linked with various cardiovascular diseases.AcknowledgementsThis work was supported by the Ministry of Health, Czech Republic, no. 00023736, by the Academy of Sciences, Czech Republic no. P205/12/G118 and NV18-08-00149, by ERDF OPPK CZ.2.16/3.1.00/24001 and...
Source: Blood - November 21, 2018 Category: Hematology Authors: Štikarova, J., Suttnar, J., Sovova, Z., Ceznerova, E., Novak, J., Louzil, J., Kotlin, R., Roselova, P., Kaufmanova, J., Chrastinova, L., Hlavackova, A., Majek, P., Kucerka, O., Hajsl, M., Maly, M., Dyr, J. E. Tags: 321. Blood Coagulation and Fibrinolytic Factors Source Type: research

Introduction of direct oral anticoagulant within 7  days of stroke onset: a nomogram to predict the probability of 3-month modified Rankin Scale score  & gt;  2
AbstractIn clinical practice, direct oral anticoagulants (DOACs) are often started earlier ( ≤ 7 days) than in randomized clinical trials after stroke. We aimed to develop a nomogram model incorporating time of DOAC introduction ≤ 7 days of stroke onset in combination with different degrees of stroke radiological/neurological severity at the time of treatment to predict the prob ability of unfavorable outcome. We conducted a multicenter prospective study including 344 patients who started DOAC 1–7 days after atrial fibrillation-related stroke onset. Computed tomography scan 24–36 h after stroke onset was ...
Source: Journal of Thrombosis and Thrombolysis - September 10, 2018 Category: Hematology Source Type: research

Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk.
CONCLUSIONS: Results support the importance of the F7 and PROCR loci on variation in circulating FVIIa and FVIIa-AT. Findings suggest FVIIa is a risk factor for ischemic stroke in older adults while higher FVIIa-AT may reflect mortality risk. This article is protected by copyright. All rights reserved. PMID: 29112333 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - November 7, 2017 Category: Hematology Authors: Olson NC, Raffield LM, Lange LA, Lange EM, Longstreth WT, Chauhan G, Debette S, Seshadri S, Reiner AP, Tracy RP Tags: J Thromb Haemost Source Type: research

Associations of activated coagulation factor VII and factor VIIa ‐antithrombin levels with genome‐wide polymorphisms and cardiovascular disease risk
ConclusionsResults support the importance of the F7 and PROCR loci on variation in circulating FVIIa and FVIIa‐AT. Findings suggest FVIIa is a risk factor for ischemic stroke in older adults while higher FVIIa‐AT may reflect mortality risk.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - November 1, 2017 Category: Hematology Authors: N. C Olson, L. M Raffield, L. A Lange, E.M. Lange, W. T Longstreth, G. Chauhan, S. Debette, S. Seshadri, A. P Reiner, R. P Tracy Tags: Original Article ‐ Coagulation Source Type: research

Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates.
Abstract Factor VII (FVII) activating protease (FSAP) is a circulating serine protease that is likely to be involved in a number of disease conditions such as stroke, atherosclerosis, liver fibrosis, thrombosis and cancer. To date, no systematic information is available about the substrate specificity of FSAP. Applying phage display and positional scanning substrate combinatorial library (PS-SCL) approaches we have characterised the specificity of FSAP towards small peptides. Results were evaluated in the context of known protein substrates as well as molecular modelling of the peptides in the active site of FSAP....
Source: Thrombosis and Haemostasis - July 20, 2017 Category: Hematology Authors: Kara E, Manna D, Løset GÅ, Schneider EL, Craik CS, Kanse S Tags: Thromb Haemost Source Type: research

Circulating microaggregates during cardiac surgery precedes postoperative stroke
This report presents intraoperative microcirculation-based evidence suggesting that observations of microaggregations, otherwise undetected by conventional anticoagulation assessment techniques, could serve as an early warning in elderly patients at high risk for postoperative cerebrovascular events.
Source: Journal of Thrombosis and Thrombolysis - May 22, 2017 Category: Hematology Source Type: research

Effects of rivaroxaban on coagulation tests in patients with non-valvular atrial fibrillation under real-life conditions
Novel oral anticoagulants (NOACs), such as direct factor Xa inhibitors, are effective alternatives for anticoagulation therapy in stroke prevention in atrial fibrillation patients.
Source: Thrombosis Research - March 7, 2017 Category: Hematology Authors: V.M. Silva, M. Scanavacca, F. Darrieux, C. Cavalheiro-Filho, C.C. Strunz Tags: Letter to the Editors-in-Chief Source Type: research

Stroke etiologic subtype may influence the rate of hyperdense middle cerebral artery sign disappearance after intravenous thrombolysis
This study suggests that stroke due to LAA is associated with lower rates of HMCAS disappearance, neurologic improvement, and mRS ≤1 after IV thrombolysis, compared with cardioembolic stroke.
Source: Journal of Thrombosis and Thrombolysis - December 31, 2016 Category: Hematology Source Type: research

Early introduction of direct oral anticoagulants in cardioembolic stroke patients with non-valvular atrial fibrillation
AbstractDirect oral anticoagulants (DOACs) are superior to warfarin in reduction of the intracranial bleeding risk. The aim of the present study was to assess whether early DOAC introduction (1 –3 days after onset) in stroke patients with non-valvular atrial fibrillation (nVAF) may be safe and effective, compared with DOAC introduction after 4–7 days. We conducted a prospective analysis based on data collected from 147 consecutive nVAF patients who started DOAC within 7 days after stro ke onset. In all patients, we performed pre-DOAC CT scan 24–36 h after onset and follow-up CT scan at 7 days after DOAC introduction...
Source: Journal of Thrombosis and Thrombolysis - September 3, 2016 Category: Hematology Source Type: research

Altered fibrin clot structure/function in patients with antiphospholipid syndrome: association with thrombotic manifestation.
Abstract We tested the hypothesis that plasma fibrin clot structure/function is unfavourably altered in patients with antiphospholipid syndrome (APS). Ex vivo plasma clot permeability, turbidity and susceptibility to lysis were determined in 126 consecutive patients with APS enrolled five months or more since thrombotic event vs 105 controls. Patients with both primary and secondary APS were characterized by 11% lower clot permeability (p<0.001), 4.8% shorter lag phase (p<0.001), 10% longer clot lysis time (p<0.001), and 4.7% higher maximum level of D-dimer released from clots (p=0.02) as compared to the ...
Source: Thrombosis and Haemostasis - March 20, 2014 Category: Hematology Authors: Celinska-Lowenhoff M, Iwaniec T, Padjas A, Musial J, Undas A Tags: Thromb Haemost Source Type: research

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