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Does the administration of sonothrombolysis along with tissue plasminogen activator improve outcomes in acute ischemic stroke? A systematic review and meta-analysis
AbstractThis meta-analysis was conducted to assess the safety and efficacy of sonothrombolysis along with intravenous recombinant tissue plasminogen activator, alteplase (IV rtPA), in the management of acute ischemic stroke. Electronic databases were searched under different meSH terms without the restriction of time and language. 1415 studies were analyzed and seven studies that matched the inclusion criteria were selected. Multiple safety and efficacy outcomes were extracted. Our pooled analysis demonstrated that there is no significant difference between sonothrombolysis group and control group in preventing mortality (...
Source: Journal of Thrombosis and Thrombolysis - June 29, 2019 Category: Hematology Source Type: research

Increased Leucocyte-Platelet Complex Formation in Recently Symptomatic versus Asymptomatic Carotid Stenosis Patients and in Micro-emboli Negative Subgroups.
CONCLUSION: These data add to the evidence that leucocyte-platelet complex formation/platelet activation is increased in recently symptomatic versus asymptomatic patients, and may contribute to the pathogenesis of first and subsequent strokes in carotid stenosis patients, including those who are MES negative. PMID: 30769362 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - February 15, 2019 Category: Hematology Authors: Murphy SJX, Lim ST, Kinsella JA, Tierney S, Egan B, Feeley TM, Murphy SM, Walsh RA, Collins DR, Coughlan T, O'Neill D, Harbison JA, Madhavan P, O'Neill SM, Colgan MP, Cox D, Moran N, Hamilton G, McCabe DJH Tags: Thromb Haemost Source Type: research

von Willebrand Factor Antigen, von Willebrand Factor Propeptide, and ADAMTS13 in Carotid Stenosis and Their Relationship with Cerebral Microemboli.
DISCUSSION:  VWF:Ag expression, a marker of endothelial ± platelet activation, is enhanced in recently symptomatic versus asymptomatic carotid stenosis patients, including in MES-ve patients, and decreases with ADAMTS13 activity over time following atherosclerotic TIA/ischemic stroke. PMID: 32932544 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - September 14, 2020 Category: Hematology Authors: Murphy SJX, Lim ST, Hickey F, Kinsella JA, Smith DR, Tierney S, Egan B, Feeley TM, Murphy SM, Collins DR, Coughlan T, O'Neill D, Harbison JA, Madhavan P, O'Neill SM, Colgan MP, O'Donnell JS, O'Sullivan JM, Hamilton G, McCabe DJH Tags: Thromb Haemost Source Type: research

Increased platelet activation in early symptomatic versus asymptomatic carotid stenosis and relationship with microembolic status: Results from the Platelets And Carotid Stenosis (PACS) Study
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - April 26, 2013 Category: Hematology Authors: JA Kinsella, WO Tobin, S Tierney, TM Feeley, B Egan, DR Collins, T Coughlan, D O'Neill, J Harbison, P Madhavan, DJ Moore, SM O'Neill, MP Colgan, CP Doherty, RP Murphy, M Saqqur, N Moran, G Hamilton, DJH McCabe Tags: Original Article ‐ Platelets Source Type: research

Increased platelet activation in early symptomatic vs. asymptomatic carotid stenosis and relationship with microembolic status: results from the Platelets and Carotid Stenosis Study
DiscussionRecently, symptomatic carotid stenosis patients have had higher platelet counts (potentially reflecting increased platelet production, mobilization or reduced clearance) and platelet activation status than asymptomatic patients. MES were more frequently detected in early symptomatic than asymptomatic patients, but the differences between late symptomatic and asymptomatic groups were not significant. Increased lymphocyte‐platelet complex formation in recently symptomatic vs. asymptomatic MES‐negative patients indicates enhanced platelet activation in this early symptomatic subgroup. Platelet biomarkers, in com...
Source: Journal of Thrombosis and Haemostasis - July 15, 2013 Category: Hematology Authors: J. A. Kinsella, W. O. Tobin, S. Tierney, T. M. Feeley, B. Egan, D. R. Collins, T. Coughlan, D. O'Neill, J. Harbison, P. Madhavan, D. J. Moore, S. M. O'Neill, M. P. Colgan, C. P. Doherty, R. P. Murphy, M. Saqqur, N. Moran, G. Hamilton, D. J. H McCabe Tags: Original Article Source Type: research

A Rabbit Model of Cerebral Microembolic Signals for Translational Research: Preclinical Validation for Aspirin and Clopidogrel
ConclusionsOur study demonstrated the successful establishment of the MES model in rabbits, which may provide translational value for MES and ischemic stroke research.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - April 30, 2016 Category: Hematology Authors: X Zhou, S Kurowski, W Wu, K Desai, L Chu, D E Gutstein, D Seiffert, X Wang Tags: Original Article ‐ Platelets Source Type: research

A Rabbit Model of Cerebral Microembolic Signals for Translational Research: Preclinical Validation for Aspirin and Clopidogrel.
CONCLUSIONS: Our study demonstrated the successful establishment of the MES model in rabbits, which may provide translational value for MES and ischemic stroke research. This article is protected by copyright. All rights reserved. PMID: 27262051 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 3, 2016 Category: Hematology Authors: Zhou X, Kurowski S, Wu W, Desai K, Chu L, Gutstein DE, Seiffert D, Wang X Tags: J Thromb Haemost Source Type: research

MRI artifacts in the ferric chloride thrombus animal model: an alternative solution
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 29, 2013 Category: Hematology Authors: Martijn Wolters, Raf H.M. Hoof, A. Wagenaar, Kim Douma, Marc A.M.J. Zandvoort, Tilman H. Hackeng, Mark J. Post, Walter H. Backes, M. Eline Kooi Tags: Letter ‐ to the Editor Source Type: research

Coagulation management with factor concentrates in liver transplantation: a single-center experience.
CONCLUSION: In LT, ROTEM-guided treatment with fibrinogen concentrate and/or PCC did not appear to increase the occurrence of thrombosis and ischemic events compared to patients who did not receive these concentrates. PMID: 24827116 [PubMed - as supplied by publisher]
Source: Transfusion - May 14, 2014 Category: Hematology Authors: Kirchner C, Dirkmann D, Treckmann JW, Paul A, Hartmann M, Saner FH, Görlinger K Tags: Transfusion Source Type: research

MRI, the technology for imaging of thrombi and inflammation.
Abstract Atherosclerosis and its sequelae have a major impact on morbidity and mortality. The rupture of an inflamed atherosclerotic plaque is a crucial event, since it can result in acute thrombotic closure of an arterial vessel, resulting e. g. in myocardial infarction or stroke. Not only detection of early plaque rupture with imminent closure is therefore of clinical interest, but also timely detection of vascular inflammation and atherosclerotic plaque progression. However, plaque inflammation or even plaque rupture without vessel occlusion is not reliably detectable by current imaging techniques. Coronary a...
Source: Hamostaseologie - January 30, 2015 Category: Hematology Authors: von Zur Muhlen C, Bode C Tags: Hamostaseologie Source Type: research

A Case of Familial Hemophagocytic Lymphohistiocytosis Type 4 With Involvement of the Central Nervous System Complicated With Infarct
Conclusions: Physicians managing patients with HLH must be vigilant about the possibility of central nervous system involvement including stroke.
Source: Journal of Pediatric Hematology Oncology - July 25, 2017 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

Rivaroxaban Thromboprophylaxis in High-Risk Ambulatory Cancer Patients Receiving Systemic Therapy: Results of a Randomized Clinical Trial (CASSINI)
Conclusions: Rivaroxaban significantly reduced VTE and VTE-related death during the on-treatment period but not during the full study period; over one-third of events occurred post discontinuation of study drug. The incidence of major bleeding was low. The Khorana risk score cut-off of ≥2 identified cancer patients at high risk of thrombotic events both at baseline (4.53%) and during study (8.79% with additional 1.66% arterial events in placebo group). These results should inform future recommendations regarding thromboprophylaxis in at-risk ambulatory cancer patients.(Funded by Janssen; ClinicalTrials.gov number, NCT02...
Source: Blood - November 21, 2018 Category: Hematology Authors: Khorana, A. A., Soff, G. A., Kakkar, A. K., Vadhan-Raj, S., Riess, H., Wun, T., Streiff, M. B., Garcia, D. A., Liebman, H. A., Belani, C., O'Reilly, E. M., Patel, J. N., Yimer, H. A., Wildgoose, P., Burton, P., Vijapurkar, U., Kaul, S., Eikelboom, J., McB Tags: Late-Breaking Abstracts Session Source Type: research

Characteristics of patients presenting with myocardial infarction with non-obstructive coronary arteries (MINOCA) in Poland: data from the ORPKI national registry
AbstractMyocardial infarction (MI) with non-obstructive coronary arteries (MINOCA) is an important clinical problem especially in the era of extensive utilization of coronary angiography in MI patients. Its pathophysiology is poorly understood which makes diagnostics and treatment of MINOCA challenging in everyday clinical practice. The aim of the study was to assess characteristics of MINOCA patients in Poland based on data from the Polish National ORPKI Registry. In 2016, 49,893 patients with non-ST-segment elevation (NSTEMI) or ST-segment elevation (STEMI) myocardial infarction entered the ORPKI registry. MINOCA was def...
Source: Journal of Thrombosis and Thrombolysis - December 18, 2018 Category: Hematology Source Type: research

Engineered Micro- and Nanoparticles for Fibrinolysis.
Abstract Fibrinolytic agents including plasmin and plasminogen activators improve outcomes in acute ischemic stroke and thrombosis by recanalizing occluded vessels. In the decades since their introduction into clinical practice, several limitations of have been identified both in terms of efficacy and bleeding risk associated with these agents. Engineered nano- and microparticles address some of these limitations by improving circulation time, reducing inhibition and degradation in circulation, accelerating recanalization, improving targeting to thrombotic occlusions, and reducing off-target effects; however, many...
Source: Thrombosis and Haemostasis - September 15, 2019 Category: Hematology Authors: Disharoon D, Marr DWM, Neeves KB Tags: J Thromb Haemost Source Type: research

Reduced dose thrombolysis with ultrasound-facilitated catheter-directed administration for acute pulmonary embolism reduces length of stay
AbstractThe optimal dose and duration of tissue plasminogen activator (tPA) administered with ultrasound-facilitated catheter-directed thrombolysis (USCDT) to patients with acute PE remains to be determined. Our institution recently adopted a shorter duration (4  h) of USCDT and lower dosing strategy (tPA 1 mg/h) based on data from the OPTALYSE PE Trial. The purpose was to evaluate the implementation at our institution of shorter duration (4 h) of USCDT and lower dosing strategy (tPA 1 mg/h) as outlined by OPTALYSE PE Trial. This was a retrospective, si ngle-center, observational study included patients from 01/01/2017...
Source: Journal of Thrombosis and Thrombolysis - December 2, 2019 Category: Hematology Source Type: research