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The influence of initial stroke severity on mortality, overall functional outcome and in-hospital placement at 90 days following acute ischemic stroke: A tertiary hospital stroke register study
Conclusions: In this acute stroke cohort, initial stroke severity had a major impact on the likelihood of death following an AIS and appears to be the dominant influence on the overall stroke outcome and in-hospital placement.
Source: Neurology India - November 10, 2017 Category: Neurology Authors: Sonu Bhaskar Peter Stanwell Andrew Bivard Neil Spratt Rhonda Walker Gemma H Kitsos Mark W Parsons Malcolm Evans Louise Jordan Michael Nilsson John Attia Christopher Levi Source Type: research

Frequency and Predictors of Early Seizures Following First Acute Stroke: Data from a University Hospital in South India
Conclusions: The frequency of early onset post-stroke seizures is 11.8%, with most of them occurring within 24 hours. Venous stroke, large lesion, cortical location, supratentorial location, hypercoaguable states, and hyperhomocysteinemia are independent predictors. Duration of hospital stay is increased in patients with early seizures, however, they did not influence the in-hospital mortality.
Source: Neurology India - September 2, 2021 Category: Neurology Authors: Surya P Turaga Rangineni L Chaithanya Abhijeet K Kohat Suvarna Alladi Subhash Kaul Source Type: research

Propensity of stroke in standard versus various aortic arch variants: A 200 patients study
Conclusions: Standard aortic arch Type 2, bovine aortic arch Type A, and Type B are associated with an early age at stroke presentation. During routine carotid evaluation by CT or MR angiography in stroke patients, it would be better to evaluate the aortic arch as well, especially in young patients.
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Swapnil Samadhiya Vijay Sardana Bharat Bhushan Dilip Maheshwari Seeta Ram Yadav Ravi Goyal Source Type: research

A hospital-based study of stroke in young from North East India
Conclusion: Although traditional risk factors are associated with stroke in young, unfavorable behavioral pattern such as alcohol abuse may cause and promote development stroke in young.
Source: Annals of Indian Academy of Neurology - September 4, 2018 Category: Neurology Authors: Masaraf Hussain Shri Ram Sharma MD Jamil Source Type: research

The Efficacy and Safety of Intravenous Thrombolysis in Older Chinese Patients with Acute Ischemic Stroke
Ming Xu, Jiamei Guo, Xianming Tao, Kebin ZengNeurology India 2021 69(1):91-96 To study the efficacy and safety of intravenous thrombolysis for the older acute ischemic stroke patients, clinical data were prospectively analyzed from 168 patients with acute ischemic stroke including 42 older adult patients (ET group), 66 younger patients (NET group) treated with rt-PA, and 60 older adult patients treated without rt-PA (ENT group). Stroke severity was assessed with an NIHSS score at baseline, 1-day and 14-day after treatment. Functional outcomes were evaluated by the modified Rankin scale and a Barthel index. Adverse effects...
Source: Neurology India - February 24, 2021 Category: Neurology Authors: Ming Xu Jiamei Guo Xianming Tao Kebin Zeng Source Type: research

Innovations in acute stroke reperfusion strategies
Venugopalan Y Vishnu, MV Padma SrivastavaAnnals of Indian Academy of Neurology 2019 22(1):6-12 Vascular neurology is witnessing unprecedented innovations in the management of acute ischemic stroke, especially in reperfusion strategies. The emergence of mechanical thrombectomy with new generation devices has revolutionized the treatment of acute ischemic stroke with large vessel occlusion. The reperfusion strategies are evolving with the extension of the window period for thrombolysis and endovascular therapy through the concept of “tissue clock” in addition to the established “time c...
Source: Annals of Indian Academy of Neurology - December 26, 2018 Category: Neurology Authors: Venugopalan Y Vishnu MV Padma Srivastava Source Type: research

Comparison of the Solitaire and Trevo Stents for Endovascular Treatment of Acute Ischemic Stroke: A Single.Center Experience
Conclusion: The Trevo stent achieved more successful recanalization with less need for rescue treatment and less time for recanalization than the Solitaire stent. There was no statistically significant difference in the clinical outcomes.
Source: Neurology India - April 24, 2021 Category: Neurology Authors: Jin Wook Baek Young Jin Heo Sung Tae Kim Jung Hwa Seo Hae Woong Jeong Eung-Gyu Kim Source Type: research

Hemorrhagic stroke and cerebral venous thrombosis: rare neurological sequelae of chickenpox infection
Anuradha Mehta, Aanchal Arora, Manoj Sharma, Rupali Malik, Yogesh Chandra PorwalAnnals of Indian Academy of Neurology 2018 21(3):228-232 Chickenpox (varicella) is primarily a disease of childhood which occurs due to infection with varicella-zoster virus (VZV). Primary VZV infection is rare in adults due to exposure in early childhood in our country. In adults, it is associated with some serious systemic and neurological complications which can follow both primary infection and reactivation of VZV. Neurological sequelae caused by primary VZV infection are rare and include encephalitis, aseptic meningitis, myelitis, acute c...
Source: Annals of Indian Academy of Neurology - September 4, 2018 Category: Neurology Authors: Anuradha Mehta Aanchal Arora Manoj Sharma Rupali Malik Yogesh Chandra Porwal Source Type: research

Acute ischemic stroke in children & #8211; should we thrombolyze ?
KP Vinayan, Vivek Nambiar, Vaishakh AnandAnnals of Indian Academy of Neurology 2022 25(1):21-25 Ischemic stroke is a major cause of acute neurological symptoms in children with significant long-term neurological sequelae. Unlike in the adult population, the clinical presentation of strokes in children may not be stereotyped. Hence, many other differential diagnostic possibilities might have to be considered in the emergency setting. Due to this heterogeneous presentation and the resultant clinical dilemma in the early detection, acute thrombolysis even now remains as a very rarely tried therapeutic option in children. Man...
Source: Annals of Indian Academy of Neurology - February 22, 2022 Category: Neurology Authors: KP Vinayan Vivek Nambiar Vaishakh Anand Source Type: research

Biosimilar tenecteplase versus alteplase in acute ischemic stroke: A real world study
Conclusion: This present study observed no difference in the efficacy and safety between biosimilar TNK and rTPA. Our findings are in concordance with published trials showing equivalence between the two molecules.
Source: Annals of Indian Academy of Neurology - January 25, 2023 Category: Neurology Authors: Ayush Mohan Snigdha Komakula Suhas Murali Pooja Anand Dyuti Shah VY Vishnu Awadh Kishor Pandit Ayush Agarwal Deepti Vibha Mamta Bhushan Singh MV Padma Srivastava Rohit Bhatia Source Type: research

Saving the brain initiative – Developing an effective hub-and-spoke model to improve the acute stroke management pathways in urban India
We aimed to develop and evaluate a hub-and-spoke model in the East Delhi by assessing knowledge and creating awareness through sensitization programs in target communities and among general physicians (GPs) along with implementation of a standard stroke management protocol (SMP) at our institute in order to extend the benefit of thrombolytic therapy.
Source: Journal of the Neurological Sciences - August 9, 2018 Category: Neurology Authors: Suman Kushwaha, Puneet Talwar, Niketa Chandel, Aldrin Anthony, Siddharth Maheshwari, Sarbjeet Khurana Source Type: research

Glasgow Coma Scale ≤ 12 at Admission is a Predictor of Poor Functional Outcome (mRS 2–6) at One Year in Patients with Cerebral Venous Thrombosis
Cerebral venous thrombosis (CVT) is a relatively uncommon cause of stroke with reported annual incidence of 0.2 –1.57 per hundred thousand population.1 Although the exact incidence of the disease in India is not known it is believed to be more common than western population especially in the young. It may occur in as much as 15–20% of all strokes occurring in age less than 40 years.2 The mean age in a lar ge series from India was around 30 years.3 Over the last few decades, the mortality rates of CVT have declined to around 4–5% due to improved diagnostic imaging, better therapeutics, and hospital care.
Source: Journal of Stroke and Cerebrovascular Diseases - April 26, 2021 Category: Neurology Authors: Salil Gupta, Rahul Soni, Pawan Dhull, Manoj Somasekharan, Amit Sreen Source Type: research

Simultaneous Acute Pulmonary Thromboembolism and Stroke & #8211; A Management Dilemma
We report the case of a 52-year-old man with concurrent massive right middle cerebral artery AIS and acute PTE, who was successfully managed despite the contradictory guidelines to manage them simultaneously. The patient underwent decompression craniotomy followed by anticoagulant therapy. The current case report demonstrates that full-dose heparin, despite being relatively contraindicated in an AIS, can achieve a good outcome when given under close monitoring. The transesophageal echo with bubble contrast during the Valsalva maneuver demonstrated patent foramen ovale with a right to left shunt as a cause of AIS and PTE in this patient.
Source: Neurology India - October 30, 2021 Category: Neurology Authors: Sita Jayalakshmi Harsh Khandalia Sudhindra Vooturi PA Jiwani Subhash Kaul Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Large Vessel Occlusions By Free Floating Thrombi in Strokes During the COVID-19 pandemic- A Single Center Observational Study
Conclusions: This study highlights the presence of FFT causing LVO as a new stroke subtype during the COVID-19 pandemic. With renewed and steeper spike in COVID-19 cases, especially new variants, the resurgence of this stroke subtype needs to be actively explored early in the course of illness to reduce morbidity and mortality.
Source: Neurology India - May 3, 2022 Category: Neurology Authors: Samhita Panda Sarbesh Tiwari Jaya Pamnani Monalisa Vegda Apoorv Patel Sanjiv Sharma Saksham Jain Pratik Patel Deepika Saroha Pushpinder Khera Naresh Midha Mayank Garg Vijaya Lakshmi Nag Source Type: research

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