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Specialty: Endocrinology
Condition: Stroke
Nutrition: Vitamins

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Total 32 results found since Jan 2013.

Vitamin D deficiency and its characteristics among patients with acute stroke at a national referral hospital in Kampala Uganda
Background: Vitamin D deficiency has been associated with acute stroke and other cardiovascular diseases in the developed world. Low 25-hydroxyvitamin D (25OHD) has been described in some populations in Sub-Saharan Africa (SSA) in spite of adequate sunshine all year round. There is no information on the magnitude of vitamin D deficiency among patients with stroke and other cardiovascular diseases in Uganda or SSA. The aim of this study was to determine the burden and characteristics of vitamin D deficiency among patients with acute stroke, the most common form of cardiovascular events in SSA. Methods: We conducted a cross-...
Source: BMC Endocrine Disorders - October 5, 2015 Category: Endocrinology Authors: Daniel KiggunduEdrisa MutebiDavis KibirigeRebecca BoxerBarbara KakandeBrian KigoziElly Katabira Source Type: research

Vitamin D may increase stroke risk
A large review of studies, published in theAnnals of Internal Medicine, on dietary supplements has not only indicated they have little benefit but also suggests that vitamin D may increase stroke risk. Medscape
Source: Society for Endocrinology - July 10, 2019 Category: Endocrinology Source Type: news

Safety and efficacy of non ‐vitamin K antagonist oral anticoagulants versus warfarin in diabetic patients with atrial fibrillation: a study‐level meta‐analysis of phase III randomized trials
ConclusionsResults of this meta‐analysis support the safety and efficacy of NOACs compared with warfarin in diabetic patients with non‐valvular AF.
Source: Diabetes/Metabolism Research and Reviews - October 31, 2016 Category: Endocrinology Authors: Giuseppe Patti, Giuseppe Di Gioia, Ilaria Cavallari, Antonio Nenna Tags: REVIEW ARTICLE Source Type: research

Matrix Gla Protein Species and Risk of Cardiovascular Events in Type 2 Diabetic Patients.
CONCLUSIONSHigh dp-ucMGP levels were associated with increased CVD risk among type 2 diabetic patients, especially with the subtypes PAD and heart failure, while other MGP species were not related to CVD risk. These results suggest that a poor vitamin K status is associated with increased CVD risk. PMID: 23877986 [PubMed - as supplied by publisher]
Source: Diabetes Care - July 22, 2013 Category: Endocrinology Authors: Dalmeijer GW, van der Schouw YT, Magdeleyns EJ, Vermeer C, Verschuren WM, Boer JM, Beulens JW Tags: Diabetes Care Source Type: research

Normocalcaemic, vitamin D sufficient hyperparathyroidism ‐ high prevalence and low morbidity in the general population A long‐term follow‐up study, the WHO MONICA project, Gothenburg, Sweden
ConclusionsThis small random population study showed that nHPT was common, 11% at follow‐up. Only one individual developed mild hypercalcaemia in 13 years. Previous S‐PTH was predictive of nHPT and hypertension was prevalent, but no increase in hard end points was seen over a 17‐year period.This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - May 18, 2015 Category: Endocrinology Authors: Georgios Kontogeorgos, Penelope Trimpou, Christine M. Laine, Göran Oleröd, Anders Lindahl, Kerstin Landin‐Wilhelmsen Tags: Rapid Communication Source Type: research

Thymosin β4: Roles in Development, Repair, and Engineering of the Cardiovascular System.
Abstract The burden of cardiovascular disease is a growing worldwide issue that demands attention. While many clinical trials are ongoing to test therapies for treating the heart after myocardial infarction (MI) and heart failure, there are few options doctors able to currently give patients to repair the heart. This eventually leads to decreased ventricular contractility and increased systemic disease, including vascular disorders that could result in stroke. Small peptides such as thymosin β4 (Tβ4) are upregulated in the cardiovascular niche during fetal development and after injuries such as MI, providing inc...
Source: Vitamins and Hormones - July 29, 2016 Category: Endocrinology Authors: Marks ED, Kumar A Tags: Vitam Horm Source Type: research

Erythropoietin: Endogenous Protection of Ischemic Brain.
Abstract The human brain requires uninterrupted delivery of blood-borne oxygen and nutrients to sustain its function. Focal ischemia, particularly, ischemic stroke, and global ischemia imposed by cardiac arrest disrupt the brain's fuel supply. The resultant ATP depletion initiates a complex injury cascade encompassing intracellular Ca(2+) overload, glutamate excitotoxicity, oxido-nitrosative stress, extracellular matrix degradation, and inflammation, culminating in neuronal and astroglial necrosis and apoptosis, neurocognitive deficits, and even death. Unfortunately, brain ischemia has proven refractory to pharmac...
Source: Vitamins and Hormones - June 23, 2017 Category: Endocrinology Authors: Mallet RT, Ryou MG Tags: Vitam Horm Source Type: research

Editorial: Telomeres and Epigenetics in Endocrinology
This study was hypothesis-driven; the genetic variants were selected for being previously and substantially genotyped. The big sample size and the rich panel of other biomarkers allowed the authors to conduct much more detailed analyses on this topic. The third article by Provenzi et al. proposed their perspectives on the role of telomeres in premature birth and discussed the potential implications for early adversity and care in the neonatal intensive care unit (Pavanello et al.). Indeed, the speculation of telomeres in aging begins in the premature aging syndrome. It is thus interesting to examine if telomeres also play...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

Associations of Serum 25(OH)D with Risk of Recurrent Cardiovascular Events in Individuals with Coronary Heart Disease
This study aimed to investigate the associations of serum 25-hydroxyvitamin D [25(OH)D] concentration and the vitamin D receptor (VDR) polymorphisms with the risk of recurrent cardiovascular events in individuals with established CHD.METHODS: A total of 22,571 participants with CHD were included from the UK Biobank. Recurrent cardiovascular events, including myocardial infarction (MI), heart failure (HF), stroke, and CVD mortality, were identified from electronic health records. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTS: The median (interquartile ra...
Source: The Journal of Clinical Endocrinology and Metabolism - June 6, 2023 Category: Endocrinology Authors: Xiaoyu Lin Xue Chen Sen Liu Yulei Deng Yuexuan Wang Qi Lu Rui Li Yunjing Ou Qingying Tian Yunfei Liao Guanglin Cui Kun Yang An Pan Gang Liu Source Type: research

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin.
CONCLUSIONSMetformin use was associated with impaired cognitive performance. Vitamin B12 and calcium supplements may alleviate metformin-induced vitamin B12 deficiency and were associated with better cognitive outcomes. Prospective trials are warranted to assess the beneficial effects of vitamin B12 and calcium use on cognition in older people with diabetes who are taking metformin. PMID: 24009301 [PubMed - as supplied by publisher]
Source: Diabetes Care - September 5, 2013 Category: Endocrinology Authors: Moore EM, Mander AG, Ames D, Kotowicz MA, Carne RP, Brodaty H, Woodward M, Boundy K, Ellis KA, Bush AI, Faux NG, Martins R, Szoeke C, Rowe C, Watters DA, the AIBL Investigators Tags: Diabetes Care Source Type: research

Future Trials Unlikely to Support Vitamin D Supplementation Future Trials Unlikely to Support Vitamin D Supplementation
Should healthy older people take vitamin-D supplements to ward off MI, stroke, or cancer? Are more trials needed to investigate this? Researchers say no to both questions, in a new analysis. Medscape Medical News
Source: Medscape Diabetes Headlines - January 24, 2014 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Top News in Endocrinology: Vitamin D Benefit Questioned
(MedPage Today) -- Topping endocrinology headlines this week, a futility analysis of randomized controlled trials found that vitamin D doesn't protect against fracture, heart attack, stroke, or cancer -- and future studies are unlikely to change that.
Source: MedPage Today Endocrinology - January 25, 2014 Category: Endocrinology Source Type: news

Evaluation of the relationship between serum apelin levels and vitamin D and mean platelet volume in diabetic patients.
CONCLUSION: We failed to show an association between vitamin D, apelin and MPV higher volumes of which may have a role in cardiovascular complications related to diabetes by increasing platelet activation. PMID: 25156130 [PubMed - as supplied by publisher]
Source: Annales d'Endocrinologie - August 22, 2014 Category: Endocrinology Authors: Kiskac M, Zorlu M, Cakirca M, Karatoprak C, Kesgin S, Büyükaydın B, Yavuz E, Ardic C, Camli AA, Cikrikcioglu MA Tags: Ann Endocrinol (Paris) Source Type: research

Endothelial nitric oxide synthase gene polymorphisms in cardiovascular disease.
Abstract Endothelial nitric oxide synthase (eNOS or NOS3), an enzyme constitutively expressed especially in endothelial cells, is largely responsible for nitric oxide (NO) bioavailability at the endothelial level. Alterations in endothelial-derived NO production have been associated with various diseases, and, in humans, can be genetically determined by the presence of different polymorphisms in the eNOS gene. To date, the most studied and functionally related polymorphisms are: Glu298Asp (rs1799983), -786T/C (rs2070744), and the intron 4 variable number tandem repeat. Evidence supports a major role of these varia...
Source: Vitamins and Hormones - September 9, 2014 Category: Endocrinology Authors: Vecoli C Tags: Vitam Horm Source Type: research

Serum 25-Hydroxy Vitamin D: A Predictor of Macrovascular and Microvascular Complications in Patients With Type 2 Diabetes.
CONCLUSIONS: Low blood 25OH-D concentrations are associated with an increased risk of macrovascular and microvascular disease events in type 2 diabetes. However, a causal link remains to be demonstrated. PMID: 25524951 [PubMed - as supplied by publisher]
Source: Diabetes Care - December 18, 2014 Category: Endocrinology Authors: Herrmann M, Sullivan DR, Veillard A, McCorquodale T, Straub IR, Scott R, Laakso M, Topliss D, Jenkins AJ, Blankenberg S, Burton A, Keech AC, for the FIELD study investigators Tags: Diabetes Care Source Type: research