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Evaluation of the effect of sodium zirconium cyclosilicate on arrhythmia-related cardiovascular outcomes in patients receiving chronic haemodialysis with hyperkalaemia: protocol for the multicentre, randomised, controlled DIALIZE-Outcomes study
Introduction Patients with kidney failure receiving chronic haemodialysis have elevated risk of arrhythmias potentially increasing the likelihood of sudden cardiac death, stroke and hospitalisation. The DIALIZE study (NCT03303521) demonstrated that sodium zirconium cyclosilicate (SZC) was an efficacious and well-tolerated treatment for predialysis hyperkalaemia in patients undergoing haemodialysis. The DIALIZE-Outcomes study evaluates the effect of SZC on sudden cardiac death and arrhythmia-related cardiovascular outcomes in patients receiving chronic haemodialysis with recurrent hyperkalaemia. Methods and analysis Intern...
Source: BMJ Open - May 25, 2023 Category: General Medicine Authors: Fishbane, S., Jadoul, M., Dember, L., Kovesdy, C., Al-Shurbaji, A., Lisovskaja, V., Sekar, P., Katona, B., Guzman, N., Herzog, C. Tags: Open access, Renal medicine Source Type: research

Replacing salt with low-sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women
CONCLUSIONS: When compared to regular salt, LSSS probably reduce blood pressure, non-fatal cardiovascular events and cardiovascular mortality slightly in adults. However, LSSS also probably increase blood potassium slightly in adults. These small effects may be important when LSSS interventions are implemented at the population level. Evidence is limited for adults without elevated blood pressure, and there is a lack of evidence in pregnant women and people in whom an increased potassium intake is known to be potentially harmful, limiting conclusions on the safety of LSSS in the general population. We also cannot draw firm...
Source: Cochrane Database of Systematic Reviews - August 9, 2022 Category: General Medicine Authors: Amanda Brand Marianne E Visser Anel Schoonees Celeste E Naude Source Type: research

8/10 --A Switch to Salt Substitute Could Slash Your Heart Risks
WEDNESDAY, Aug. 10, 2022 -- Swapping salt out for the salt substitute potassium chloride lowers blood pressure, and thereby the risk of heart attack, stroke and cardiovascular disease, a new analysis finds. " It ' s in processed and prepared foods...
Source: Drugs.com - Daily MedNews - August 8, 2022 Category: General Medicine Source Type: news

Salt Substitute Cut Disease and Death Rates in Large Trial
A randomized trial recently reported in the New England Journal of Medicine focused on an important question for older adults with high blood pressure or a previous stroke: Can switching from regular salt to a 75% sodium chloride and 25% potassium chloride substitute help protect against stroke, major cardiovascular events, or death?
Source: JAMA - October 26, 2021 Category: General Medicine Source Type: research

Early postoperative effects of kidney transplantation on the cardiovascular system in our clinical practice
CONCLUSION: After transplantation, the left atrial and the end-systolic diameter of the left ventricle regrediated, decreasing the frequency of arrhythmic episodes. The number of the middle grade mitral valve regurgitation decreased and the calcification among diabetic population increased significantly. Orv Hetil. 2021; 162(26): 1052-1062.PMID:34175832 | DOI:10.1556/650.2021.32269
Source: Orvosi Hetilap - June 27, 2021 Category: General Medicine Authors: Andrea Darag ó Gerda Schwegler Eszter Szab ó Dorina Bark ó R éka P Szabó Attila Csaba Nagy Gerg ő József Szőllősi Bal ázs Nemes Source Type: research

A vesetranszplant áció korai posztoperatív hatásai a szív- és érrendszeri betegségekre klinikai gyakorlatunkban
CONCLUSION: After transplantation, the left atrial and the end-systolic diameter of the left ventricle regrediated, decreasing the frequency of arrhythmic episodes. The number of the middle grade mitral valve regurgitation decreased and the calcification among diabetic population increased significantly. Orv Hetil. 2021; 162(26): 1052-1062.PMID:34175832 | DOI:10.1556/650.2021.32269
Source: Orvosi Hetilap - June 27, 2021 Category: General Medicine Authors: Andrea Darag ó Gerda Schwegler Eszter Szab ó Dorina Bark ó R éka P Szabó Attila Csaba Nagy Gerg ő József Szőllősi Bal ázs Nemes Source Type: research

Early postoperative effects of kidney transplantation on the cardiovascular system in our clinical practice
CONCLUSION: After transplantation, the left atrial and the end-systolic diameter of the left ventricle regrediated, decreasing the frequency of arrhythmic episodes. The number of the middle grade mitral valve regurgitation decreased and the calcification among diabetic population increased significantly. Orv Hetil. 2021; 162(26): 1052-1062.PMID:34175832 | DOI:10.1556/650.2021.32269
Source: Orvosi Hetilap - June 27, 2021 Category: General Medicine Authors: Andrea Darag ó Gerda Schwegler Eszter Szab ó Dorina Bark ó R éka P Szabó Attila Csaba Nagy Gerg ő József Szőllősi Bal ázs Nemes Source Type: research

Postoperative malignant hyperthermia confirmed by calcium-induced calcium release rate after breast cancer surgery, in which prompt recognition and immediate dantrolene administration were life-saving: a case report
ConclusionsThe occurrence of MH can be life-threatening, but its frequency is very low, and genetic testing and muscle biopsy are required to confirm the diagnosis. On retrospective evaluation using the malignant hyperthermia scale, the present case was almost certainly that of a patient with MH. Prompt recognition and immediate treatment with dantrolene administration and body cooling effectively reversed a potentially fatal syndrome. This was hence a valuable case of a patient with postoperative MH that led to a confirmed diagnosis by CICR.
Source: Journal of Medical Case Reports - April 17, 2021 Category: General Medicine Source Type: research

Potassium binders for chronic hyperkalaemia in people with chronic kidney disease.
CONCLUSIONS: Evidence supporting clinical decision-making for different potassium binders to treat chronic hyperkalaemia in adults with CKD is of low certainty; no studies were identified in children. Available studies have not been designed to measure treatment effects on clinical outcomes such as cardiac arrhythmias or major GI symptoms. This review suggests the need for a large, adequately powered study of potassium binders versus placebo that assesses clinical outcomes of relevance to patients, clinicians and policy-makers. This data could be used to assess cost-effectiveness, given the lack of definitive studies and t...
Source: Cochrane Database of Systematic Reviews - June 25, 2020 Category: General Medicine Authors: Natale P, Palmer SC, Ruospo M, Saglimbene VM, Strippoli GF Tags: Cochrane Database Syst Rev Source Type: research

Rhabdomyolysis of Unknown Etiology - Initial Suspicion and Detection on 99mTc-MDP Skeletal Scintigraphy.
Authors: Kumar NS, Basu S Abstract The classical bone scan findings of Rhabdomyolysis is presented in this illustration. A 60 year old female patient with complaints of low backache and bilateral lower limbs weakness over 1 year was referred for whole body skeletal status evaluation. Whole body skeletal scintigraphy undertaken 3 hrs after I.V injection of 15 mci of 99mTc-MDP revealed bilaterally symmetrical diffuse skeletal muscle tracer activity in deltoid, lattisimus dorsi, diaphragm, paraspinal muscles, gluteus muscles and muscles of thigh. On biochemical investigations for evaluation of skeletal muscle uptake r...
Source: Journal of the Association of Physicians of India - October 22, 2018 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

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