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Enhanced recovery from chronic ischemic injury by bone marrow cells in a rat model of ischemic stroke.
This study provides valuable insights into the effect of BMC transplantation in the chronic ischemic brain, which lead to the development of effective therapy for chronic stroke patients who currently lack satisfactory therapeutic options. PMID: 24152766 [PubMed - as supplied by publisher]
Source: Cell Transplantation - October 22, 2013 Category: Cytology Authors: Yoo J, Seo JJ, Eom JH, Hwang DY Tags: Cell Transplant Source Type: research

Intranasal Delivery of Bone Marrow Mesenchymal Stem Cells Improved Neurovascular Regeneration and Rescued Neuropsychiatric Deficits after Neonatal Stroke in Rats.
Abstract Neonatal stroke is a major cause of mortality and long-term morbidity in infants and children. Currently very limited therapeutic strategies are available to protect the developing brain against ischemic damage and promote brain repairs for pediatric patients. Moreover, children who experienced neonatal stroke often have developmental social behavior problems. Cellular therapy using bone marrow mesenchymal stem cells (BMSCs) has emerged as a regenerative therapy after stroke. In the present investigation, neonatal stroke of postnatal day 7 (P7) rat pups was treated with non-invasive and brain specific int...
Source: Cell Transplantation - February 2, 2015 Category: Cytology Authors: Wei ZZ, Gu X, Ferdinand A, Lee JH, Ji X, Ji XM, Yu SP, Wei L Tags: Cell Transplant Source Type: research

Fibrinogen reduction and motor function improvement by hematopoietic growth factor treatment in chronic stroke in aged mice: a treatment frequency study.
This study provides new insight into understanding of the potential contribution of SCF+G-CSF in both reducing the risk of recurrent ischemic stroke and enhancing stroke recovery. PMID: 26817662 [PubMed - as supplied by publisher]
Source: Cell Transplantation - January 26, 2016 Category: Cytology Authors: Liu Y, Popescu M, Longo S, Gao M, Wang D, McGillis S, Zhao LR Tags: Cell Transplant Source Type: research

Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke.
Abstract Stroke is a major disease that leads to high mortality and morbidity. Given the ageing population and the potential risk factors, the prevalence of stroke and socioeconomic burden associated with stroke are expected to increase. During the past decade, both prophylactic and therapeutic strategies for stroke have made significant progress. However, current therapies still cannot adequately improve the outcomes of stroke and may not apply to all patients. One of the significant advances in modern medicine is cell-derived neurovascular regeneration and neuronal repair. Progress in stem cell biology has great...
Source: Cell Transplantation - September 25, 2018 Category: Cytology Authors: Wang F, Tang H, Zhu J, Zhang JH Tags: Cell Transplant Source Type: research

Therapeutic Target and Cell-signal Communication of Chlorpromazine and Promethazine in Attenuating Blood-Brain Barrier Disruption after Ischemic Stroke.
This study clearly indicates a beneficial effect of C+P on BBB integrity after stroke, which may be independent of drug-induced hypothermia. These findings further prove the clinical target and cell-signal communication of C+P treatment, which may direct us closer toward the development of an efficacious neuroprotective therapy. PMID: 30569751 [PubMed - as supplied by publisher]
Source: Cell Transplantation - December 20, 2018 Category: Cytology Authors: Li F, Geng X, Yip J, Ding Y Tags: Cell Transplant Source Type: research

Upregulation of MicroRNA-128 in the Peripheral Blood of Acute Ischemic Stroke Patients is Correlated with Stroke Severity Partially through Inhibition of Neuronal Cell Cycle Reentry.
Abstract MiR-128, one of the most enriched miRNAs in the human brain, has been reported to protect MCAO mice via inhibiting P38α MAPK. Whether it is involved in pathogenesis in acute ischemic stroke patients remains to be determined. The present study focused on the clinical importance of miR-128 and its underlying mechanisms. We detected miR-128 levels in the circulating lymphocytes, neutrophils, and plasma of acute ischemic stroke patients by using RT-PCR. miR-128 levels were significantly elevated in circulating lymphocytes, neutrophils, and plasma of patients with acute ischemic stroke. In addition, miR-128 l...
Source: Cell Transplantation - April 29, 2019 Category: Cytology Authors: Liu P, Han Z, Ma Q, Liu T, Wang R, Tao Z, Li G, Li F, Zhang S, Li L, Ji X, Zhao H, Luo Y Tags: Cell Transplant Source Type: research

Safety and therapeutic potential of M2-macrophages in stroke treatment.
Abstract Our objective was to evaluate the safety and clinical efficacy of autologous M2 macrophage transplantation in non-acute stroke patients. We also evaluated whether the intrathecal administration of macrophages influences the production of cytokines by peripheral blood cells, and whether the levels of cytokines correlate with stroke severity and responsiveness to celltherapy. For this, thirteen patients (12 males and one female with median 63 years) diagnosed with ischemic (n=10) or hemorrhagic (n=3) stroke have been subjected to cell transplantation therapy (study group). On average 21.9 x 10(6) of autolog...
Source: Cell Transplantation - December 14, 2015 Category: Cytology Authors: Chernykh ER, Shevela EY, Starostina NM, Morozov SA, Davydova MN, Menyaeva EV, Ostanin AA Tags: Cell Transplant Source Type: research

Stroke serum priming modulates characteristics of mesenchymal stromal cells by controlling the expression miRNA-20a.
Abstract Transplantation of mesenchymal stem cells (MSCs), expanded with fetal bovine serum (FBS), has some limitations, including a long culture period required to obtain sufficient stem cells. Priming of MSCs with serum from patients with ischemic stroke (stroke serum) increased the proliferation rate and the neurorestorative capacity of MSCs. We hypothesized that this novel priming method increases the proliferation rate of MSCs via the regulation of microRNAs (miRs). Thus, we investigated miR profiling in stroke serum primed MSCs and tested whether the regulation of certain miRs may affect the proliferation ra...
Source: Cell Transplantation - January 13, 2016 Category: Cytology Authors: Kim EH, Kim DH, Kim HR, Kim SY, Kim HH, Bang OY Tags: Cell Transplant Source Type: research

Therapeutic effect of ligustilide-stimulated adipose-derived stem cells in a mouse thromboembolic stroke model.
Abstract Stroke is a result of cerebral ischemia that triggers a cascade of both physiological and biochemical events. No effective treatment is available for stroke; however, stem cells have potential for use in rescue from the effects of stroke. Adipose-derived stem cells (ADSCs) are an abundant source of adult stem cells; therefore, ADSC therapy can be considered as a future strategy for regenerative medicine. However, more research is required to improve the effectiveness of transplanted ADSCs as a treatment for stroke in the mouse stroke model. Ligustilide isolated from the herb Angelica sinensis exhibits a n...
Source: Cell Transplantation - January 18, 2016 Category: Cytology Authors: Chi K, Fu RH, Huang YC, Chen SY, Lin SZ, Huang PC, Lin PC, Chang FK, Liu SP Tags: Cell Transplant Source Type: research

Breaking the blood brain barrier to aid stem cell therapeutics in the chronic stroke brain.
Abstract Blood brain barrier (BBB) permeabilizers, such as mannitol, can facilitate peripherally delivered stem cells to exert the therapeutic benefits on the stroke brain. Although this BBB permeation-aided stem cell therapy has been demonstrated in the acute stage of stroke, such BBB permeation in the chronic stage of the disease remains to be examined. Adult Sprague-Dawley rats initially received sham surgery or experimental stroke via the one-hour middle cerebral artery occlusion (MCAo) model. At one month after the MCAo surgery, stroke animals were randomly assigned to receive human umbilical cord stem cells ...
Source: Cell Transplantation - February 15, 2016 Category: Cytology Authors: Tajiri N, Lee JY, Acosta S, Sanberg PR, Borlongan CV Tags: Cell Transplant Source Type: research

Improving neurorepair in stroke brain through endogenous neurogenesis-enhancing drugs.
Abstract Stroke induces not only cell death but also neurorepair. De novo neurogenesis has been found in the subventricular zone(SVZ) of adult mammalian brain days after stroke. Most of these newly generated cells die shortly after the insult. Recent studies have shown that pharmacological manipulation can improve the survival of endogenous neuroprogenitor cells and neural regeneration in stroke rats. As these drugs target the endogenous reparative processes which occur days after stroke, they may provide a prolonged window for stroke therapy. Here, we discuss endogenous neurogenesis-enhancing drugs, and review th...
Source: Cell Transplantation - April 26, 2017 Category: Cytology Authors: Wu KJ, Yu S, Lee JY, Hoffer B, Wang Y Tags: Cell Transplant Source Type: research

Improving Neurorepair in Stroke Brain Through Endogenous Neurogenesis-Enhancing Drugs.
Abstract Stroke induces not only cell death but also neurorepair. De novo neurogenesis has been found in the subventricular zone of the adult mammalian brain days after stroke. Most of these newly generated cells die shortly after the insult. Recent studies have shown that pharmacological manipulation can improve the survival of endogenous neuroprogenitor cells and neural regeneration in stroke rats. As these drugs target the endogenous reparative processes that occur days after stroke, they may provide a prolonged window for stroke therapy. Here, we discuss endogenous neurogenesis-enhancing drugs and review the g...
Source: Cell Transplantation - September 1, 2017 Category: Cytology Authors: Wu KJ, Yu S, Lee JY, Hoffer B, Wang Y Tags: Cell Transplant Source Type: research

Potential of Exosomes for the Treatment of Stroke.
Abstract Stroke is the result of blockage or rupture of blood vessels in the brain and is the leading cause of death and disability in the world. Currently only a very limited number of therapeutic approaches are available for treatment of stroke patients, and the vast majority of neuroprotective agents that tested positively in pre-clinical studies failed in clinical trials. In recent years, the clinical value of the use of exosomes for stroke treatment has received widespread attention due their unique characteristics such as low immunogenicity, low toxicity and biodegradability, ability to cross the blood-brain...
Source: Cell Transplantation - December 6, 2018 Category: Cytology Authors: Hong SB, Yang H, Manaenko A, Lu J, Mei Q, Hu Q Tags: Cell Transplant Source Type: research

Secondary Pathology of the Thalamus after Focal Cortical Stroke in Rats is not Associated with Thermal or Mechanical Hypersensitivity and is Not Alleviated by Intra-Thalamic Post-Stroke Delivery of Recombinant CDNF or MANF.
Abstract A stroke affecting the somatosensory pathway can trigger central post-stroke pain syndrome (CPSP). The symptoms often include hyperalgesia, which has also been described in rodents after the direct damage of the thalamus. Previous studies have shown that hemorrhagic stroke or ischemia caused by vasoconstriction in the thalamus induces increased pain sensitivity. We investigated whether inducing secondary damage in the thalamus by a cortical stroke causes similar pain hypersensitivity as has previously been reported with direct ischemic injury. We induced a focal cortical ischemia-reperfusion injury in mal...
Source: Cell Transplantation - April 29, 2019 Category: Cytology Authors: Anttila JE, Pöyhönen S, Airavaara M Tags: Cell Transplant Source Type: research

Multiple Cell Transplant for Stroke Patients Multiple Cell Transplantation Based on an Intraparenchymal Approach for Patients with Chronic Phase Stroke.
Abstract Stroke is the third leading cause of death worldwide and a huge perpetrator in adult disability. This pilot clinical study investigates the possible benefits of transplanting multiple cells in chronic stroke. A total of ten consecutive stroke patients were treated by combination cell transplantation on the basis of an intraparenchymal approach from November 2003 to April 2011. There were 6 males and 4 females. Their age ranged from 42 to 87 years and course of disease varied from 6 months to 20 years. Six patients suffered cerebral infarction, and 4 patients suffered a brain hemorrhage. The olfactory ensh...
Source: Cell Transplantation - August 29, 2013 Category: Cytology Authors: Chen L, Xi H, Huang H, Zhang F, Liu Y, Chen D, Xiao J Tags: Cell Transplant Source Type: research

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