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Condition: ALS
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Total 644 results found since Jan 2013.
'Computer helps patients with severe MND communicate'
Conclusion
It's hard to imagine the situation of being alert, aware of what's happening around you, but unable to move, respond or communicate with the outside world.
So it is comforting, then, to hear that people with complete locked-in syndrome may be able to communicate – and may be relatively content with their situation.
However, it's important to remember the limitations of this study.
It's very small. Only four people took part, and full results are available for only three of them.
The results may only apply to people with this very specific type of neurodegenerative disease, not to people with other types of pa...
Source: NHS News Feed - February 1, 2017 Category: Consumer Health News Tags: Neurology Source Type: news
'Breakthrough in communication for patients with severe MND', study claims
Conclusion
It's hard to imagine the situation of being alert, aware of what's happening around you, but unable to move, respond or communicate with the outside world.
So it is comforting, then, to hear that people with complete locked-in syndrome may be able to communicate – and may be relatively content with their situation.
However, it's important to remember the limitations of this study.
It's very small. Only four people took part, and full results are available for only three of them.
The results may only apply to people with this very specific type of neurodegenerative disease, not to people with other types of pa...
Source: NHS News Feed - February 1, 2017 Category: Consumer Health News Tags: Neurology Source Type: news
Isotropic Generalized Diffusion Tensor MRI
Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have developed a method implemented as pulse sequences and software to be used with magnetic resonance imaging (MRI) scanners and systems. This technology is available for licensing and commercial development. The method allows for measuring and mapping features of the bulk or average apparent diffusion coefficient (ADC) of water in tissue – aiding in stroke diagnosis and cancer therapy assessment. The pulse sequences and software enable MRI scanners to yield diffusion weighted images (DWI) that are orientationally ...
Source: NIH OTT Licensing Opportunities - August 16, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research
Patient characteristics and outcomes of a home mechanical ventilation program in a developing country
Conclusions: HMV is feasible for patients with neurological diseases and COPD in a developing country. The relatively high rate of complications indicates the need for more comprehensive clinical services for chronic ventilator-dependent patients in this setting.
Source: Lung India - April 23, 2019 Category: Respiratory Medicine Authors: Narongkorn Saiphoklang Apichart Kanitsap Pitchayapa Ruchiwit Pattarin Pirompanich Thiti Sricharoenchai Christopher B Cooper Source Type: research
Impact of Air Pollution and Seasonal Haze on Neurological Conditions.
CONCLUSION: Air pollution is associated with increased risk of certain common neurological disorders. More specific studies are needed to investigate the impact of seasonal haze on neurological conditions in Southeast Asia.
PMID: 32200394 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - December 31, 2019 Category: General Medicine Authors: Rocha II, Narasimhalu K, De Silva DA Tags: Ann Acad Med Singapore Source Type: research
Neuroprotection by Mucuna pruriens in Neurodegenerative Diseases
Neurochem Res. 2022 Apr 5. doi: 10.1007/s11064-022-03591-3. Online ahead of print.ABSTRACTThe medicinal plant Mucuna pruriens (Fabaceae) is widely known for its anti-oxidative and anti-inflammatory properties. It is a well-established drug in Ayurveda and has been widely used for the treatment of neurological disorders and male infertility for ages. The seeds of the plant have potent medicinal value and its extract has been tested in different models of neurodegenerative diseases, especially Parkinson's disease (PD). Apart from PD, Mucuna pruriens is now being studied in models of other nervous systems disorders such as Al...
Source: Neurochemical Research - April 5, 2022 Category: Neuroscience Authors: Walia Zahra Hareram Birla Saumitra Sen Singh Aaina Singh Rathore Hagera Dilnashin Richa Singh Priyanka Kumari Keshri Priyanka Gautam Surya Pratap Singh Source Type: research
HMGB1 in nervous system diseases: A common biomarker and potential therapeutic target
High-mobility group box-1 (HMGB1) is a nuclear protein associated with early inflammatory changes upon extracellular secretion expressed in various cells, including neurons and microglia. With the progress of research, neuroinflammation is believed to be involved in the pathogenesis of neurological diseases such as Parkinson's, epilepsy, and autism. As a key promoter of neuroinflammation, HMGB1 is thought to be involved in the pathogenesis of Parkinson's disease, stroke, traumatic brain injury, epilepsy, autism, depression, multiple sclerosis, and amyotrophic lateral sclerosis. However, in the clinic, HMGB1 has not been de...
Source: Frontiers in Neurology - October 31, 2022 Category: Neurology Source Type: research
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
Conclusions:
Our results suggest that the TREM2 p.R47H substitution is a risk factor for frontotemporal dementia and Parkinson's disease in addition to Alzheimer's disease. These findings suggest a more general role for TREM2 dysfunction in neurodegeneration, which could be related to its role in the immune response.
Source: Molecular Neurodegeneration - June 21, 2013 Category: Neurology Authors: Sruti RayaproluBianca MullenMatt BakerTimothy LynchElizabeth FingerWilliam SeeleyKimmo HatanpaaCatherine Lomen-HoerthAndrew KerteszEileen BigioCarol LippaKeith JosephsDavid KnopmanCharles WhiteRichard CaselliIan MackenzieBruce MillerMagdalena Boczarska-Je Source Type: research
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson¿s disease
Conclusions:
Our results suggest that the TREM2 p.R47H substitution is a risk factor for frontotemporal dementia and Parkinson’s disease in addition to Alzheimer’s disease. These findings suggest a more general role for TREM2 dysfunction in neurodegeneration, which could be related to its role in the immune response.
Source: Molecular Neurodegeneration - June 21, 2013 Category: Neurology Authors: Sruti RayaproluBianca MullenMatt BakerTimothy LynchElizabeth FingerWilliam SeeleyKimmo HatanpaaCatherine Lomen-HoerthAndrew KerteszEileen BigioCarol LippaKeith JosephsDavid KnopmanCharles WhiteRichard CaselliIan MackenzieBruce MillerMagdalena Boczarska-Je Source Type: research
Diane Stephenson
is a neuroscientist by training with 30 years combined experience in academic neuroscience and drug discovery. She is passionate about translational science and has a long time dedication to the discovery of therapies to treat diseases of the nervous system. Diane received her undergraduate degree in Biochemistry at University of California, Santa Barbara and her Ph.D. in Medical Neurobiology from Indiana University. In her academic career, Diane focused her research on Amyotrophic Lateral Sclerosis and Alzheimer's disease while in industry she focused on drug discovery for Alzheimer's disease, stroke and Parkinson'...
Source: PHRMA - November 5, 2013 Category: Pharmaceuticals Authors: Leah Source Type: news
Diane Stephenson, Ph.D.
EVP, Coalition Against Major DiseasesDiane Stephenson is a neuroscientist by training with 30 years combined experience in academic neuroscience and drug discovery. She is passionate about translational science and has a long time dedication to the discovery of therapies to treat diseases of the nervous system. Diane received her undergraduate degree in Biochemistry at University of California, Santa Barbara and her Ph.D. in Medical Neurobiology from Indiana University. In her academic career, Diane focused her research on Amyotrophic Lateral Sclerosis and Alzheimer's disease while in industry she focused on drug dis...
Source: PHRMA - November 5, 2013 Category: Pharmaceuticals Authors: Leah Source Type: news
Membrane‐type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases
We previously reported that glioma cells induce the expression of membrane‐type 1 metalloproteinase (MT1‐MMP or MMP‐14) in tumor‐associated microglia/macrophages and promote tumor growth, whereas MMP‐14 expression in microglia under physiological conditions is very low. Here, we show that the increase in MMP‐14 expression is also found in microglia/macrophages associated with neurodegenerative and neuroinflammatory pathologies in mouse models as well as in human biopsies or post‐mortem tissue. We found that microglial/macrophage MMP‐14 expression was upregulated in Alzheimer's disease tissue, in active lesi...
Source: Journal of Neuroscience Research - December 10, 2013 Category: Neuroscience Authors: Anika Langenfurth, Jan Leo Rinnenthal, Katyayni Vinnakota, Vincent Prinz, Anne‐Sophie Carlo, Christine Stadelmann, Volker Siffrin, Susann Peaschke, Matthias Endres, Frank Heppner, Rainer Glass, Susanne A. Wolf, Helmut Kettenmann Tags: Research Article Source Type: research
Dextromethorphan and Quinidine for Treatment of Pseudobulbar Affect (PBA): Time Course of PBA Episode Remission (S31.007)
Conclusions: Approximately half of patients receiving DMQ-20 experienced PBA episode remission during this 12-week pivotal trial. Significant differences vs. placebo in the percentage of patients entering remission emerged early (Week 1) and remained significant in subsequent trial weeks.Study Supported by: Avanir Pharmaceuticals, Inc.Disclosure: Dr. Formella has received personal compensation for activities with Avanir Pharmaceuticals Inc. as an employee. Dr. Brooks has received personal compensation for activities with Biogen Idec, Avanir Pharmaceuticals, Acorda Therapeutics, Cytokinetics, Synapse, and the National Insti...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Formella, A., Brooks, B. Tags: General Neurology I Source Type: research
Amyotrophic Lateral Sclerosis Quality Measures (S46.006)
CONCLUSIONS: The AAN ALS quality measures, when implemented by providers, have the potential to significantly improve care for individuals with ALS.Study Supported by:Disclosure: Dr. Miller has received personal compensation for activities with Celgene, Pharmacyclic, Teva Neuroscience, and Taiji. Dr. Brooks has received personal compensation for activities with Biogen Idec, Avanir Pharmaceuticals, Acorda Therapeutics, Cytokinetics, Synapse, and the National Institute of Neurological Disorders and Stroke. Dr. Brooks has received research support from Biogen Idec, Avanir Pharmaceuticals, Cytokinetics, Neuraltus Pharmaceutica...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Miller, R., Brooks, B., Swain-Eng, R., Basner, R., Carter, G., Casey, P., Cohen, A., Dubinsky, R., Forshew, D., Jackson, C., Kasarskis, E., Procaccini, N., Sanjak, M., Tolin, F. Tags: Neuromuscular Disease: Genetics, Pathogenesis, and Measures Source Type: research
