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Specialty: Neurology
Condition: Patent Foramen Ovale
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Total 305 results found since Jan 2013.
Patent Foramen Ovale in Cryptogenic Ischemic Stroke: Direct Cause, Risk Factor, or Incidental Finding?
Patent foramen ovale (PFO) has been associated with cryptogenic stroke. There is conflicting data and it remains uncertain whether PFO is the direct cause, a risk factor or an incidental finding. Potential stroke mechanisms include paradoxical embolism from a venous clot which traverses the PFO, in situ clot formation within the PFO, and atrial arrhythmias due to electrical signaling disruption. Main risk factors linked with PFO-attributable strokes are young age, PFO size, right-to-left shunt degree, PFO morphology, presence of atrial septal aneurysm, intrinsic coagulation-anticoagulation systems imbalance, and co-existen...
Source: Frontiers in Neurology - June 24, 2020 Category: Neurology Source Type: research
A systematic review of closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and cryptogenic stroke or transient ischemic attack
Abstract: The optimal treatment for secondary prevention in patients who have a patent foramen ovale (PFO) and history of cryptogenic stroke is still uncertain and controversial. In view of this, we performed a systematic review of randomized controlled trials (RCTs) to investigate whether PFO closure was superior to medical therapy for prevention of recurrent stroke or transient ischemic attack (TIA) in patients with PFO after cryptogenic stroke. We searched the Cochrane Central Register of Controlled Trials, Embase, PubMed, Web of Science, and ClinicalTrials.gov. Three randomized controlled trials with a total of 2303 pa...
Source: Journal of the Neurological Sciences - December 2, 2013 Category: Neurology Authors: Linkun Chen, Shuguang Luo, Lingwan Yan, Weijia Zhao Tags: Review Source Type: research
Prevalence of migraine headache in an in‐patient stroke population
ConclusionsThe prevalence of migraine in this hospital‐based stroke cohort was comparable to the estimated prevalence of migraine usually described in population studies. In our study population, the prevalence of migraine with aura was higher than expected. The increased prevalence of PFO in patients with migraine headache corresponds well to previous population studies.
Source: Acta Neurologica Scandinavica - October 23, 2014 Category: Neurology Authors: M. Lantz, K. Kostulas, E. Waldenlind, C. Sjöstrand Tags: Original Article Source Type: research
Value of Eye Movement Exam in Aiding Precise Localization in Stroke (P1.016)
We present an unusual presentation of midbrain stroke presenting with bilateral ptosis in an African American male with vascular risk factors and concurrent use of bevacizumab. This case illustrates how detailed knowledge of anatomy and detailed neurologic exam remain valuable tools for localizing and diagnosing subtle presentations of common neurologic disease. Case description: A 69 year-old African American man with vascular risk factors including hypertension, hyperlipidemia and poorly controlled diabetes experienced sudden onset horizontal diplopia associated with fatigue. The patient presented to the Emergency Depart...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Khandker, N., Schmerler, D., Mahajan, S., Serra, A., Strbian, D. Tags: Cerebrovascular Disease and Interventional Neurology I ePosters Source Type: research
Analysis of Inpatient Thrombophilia Testing for Adults with an Ischemic Stroke or Transient Ischemic Attack and its Impact on Clinical Management (P1.123)
Conclusions: Inpatient thrombophilia testing did not affect management in the vast majority of patients with an ischemic stroke or TIA despite a positive test result. Therefore, by avoiding inpatient testing, healthcare costs may be reduced without affecting patient care.Disclosure: Dr. Gavva has nothing to disclose. Dr. Alberts has received personal compensation for activities with AGA medical, AstraZeneca, Bayer, Pfizer, Bistol-Myers-Squibb, Boehringer Ingelheim, diaDexus, Genentech, KOS, Medicine Company, PDL biopharma, Pfizer, Photothera, Sanofi. Dr. Johnson has nothing to disclose. Dr. Sarode has received personal com...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Gavva, C., Alberts, M., Johnson, M., Sarode, R. Tags: Cerebrovascular Disease: Epidemiology Source Type: research
Cryptogenic stroke and patent foramen ovale: The role of Valsalva maneuver and prolonged immobility (P3.079)
Conclusions:Our study provides an estimated prevalence of Valsalva maneuver and prolonged immobility in patients with CS and PFO. The analysis suggests a possible association between high RoPE score and prolonged immobility, in patients with Valsalva at the time of symptom onset. Further investigations with larger sample sizes are required to reach more precise estimates for the associations examined.Disclosure: Dr. Daneshmand has nothing to disclose. Dr. Koulouridis has nothing to disclose. Dr. Thaler has received personal compensation for activities with St. Jude Medical WL and Gore Associates as a consultant.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Daneshmand, A., Koulouridis, I., Thaler, D. Tags: Cerebrovascular Disease and Interventional Neurology ePoster Session Source Type: research
Long-term Risk of Complications after Percutaneous Transcatheter Closure of Patent Foramen Ovale (S51.003)
Conclusions:Approximately 1 in 6 patients who undergo percutaneous transcatheter closure of PFO after stroke or transient ischemic attack experience a serious complication or death within 5 years.Study Supported by:Dr. Gialdini is supported by the Feil Family Foundation.Dr. Navi is supported by NIH grant K23NS091395 and the Florence Gould Endowment for Discovery in Stroke.Dr. Iadecola is supported by NIH grants R37NS089323-02, R01NS034179-21, R01NS037853-19, and R01 NS073666-04.Dr. Kamel is supported by NIH grants K23NS082367 and R01NS097443 as well as the Michael Goldberg Research Fund.Disclosure: Dr. Merkler has nothing ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Merkler, A., Gialdini, G., Yaghi, S., Okin, P., Iadecola, C., Navi, B., Kamel, H. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research
Transcatheter Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke: A Meta-Analysis of Randomized Controlled Trials
Conclusion: Pooled data from 5 large RCTs showed that PFO closure in patients with cryptogenic stroke is safe and effective intervention for prevention of stroke recurrence compared with medical therapy.Cerebrovasc Dis 2018;45:162 –169
Source: Cerebrovascular Diseases - March 29, 2018 Category: Neurology Source Type: research
Clinical RoPE (cRoPE) score predicts patent foramen ovale detection among stroke patients: a multicenter observational study
ConclusionsConclusions: cRoPE might help in stratification of patients with CS, allowing accurate esteem of the likelihood of PFO to be found, especially in cases when neuroimaging is inconclusive.
Source: Neurological Sciences - May 8, 2020 Category: Neurology Source Type: research
Brain Infarction MRI Pattern in Stroke Patients with Intracardiac Thrombus
Conclusions: ICT-related stroke is associated with acute SCCI presence on MRI.Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT04456309.Cerebrovasc Dis
Source: Cerebrovascular Diseases - June 17, 2021 Category: Neurology Source Type: research
Current Challenges and Future Directions in Handling Stroke Patients With Patent Foramen Ovale —A Brief Review
The role of patent foramen ovale (PFO) in stroke was debated for decades. Randomized clinical trials (RCTs) have shown fewer recurrent events after PFO closure in patients with cryptogenic stroke (CS). However, in clinical practice, treating stroke patients with coexisting PFO raises some questions. This brief review summarizes current knowledge and challenges in handling stroke patients with PFO and identifies issues for future research. The rationale for PFO closure was initially based on the concept of paradoxical embolism from deep vein thrombosis (DVT). However, RCTs did not consider such details, limiting their impac...
Source: Frontiers in Neurology - April 28, 2022 Category: Neurology Source Type: research
Differences in clinical and biological factors between patients with PFO-related stroke and patients with PFO and no cerebral vascular events
We present a study concerning clinical, demographic, and laboratory factors associated with stroke and transient ischemic attack in patients with patent foramen ovale (PFO), as well as comparing PFO-patients with and without cerebrovascular ischemic events (CVEs).Patients and methodsConsecutive patients with PFO-associated CVEs were included in the study; control group was selected from patients with a PFO and no history of stroke. All participants underwent peripheral routine blood analyses, as well as, on treating physician's recommendations, screening for thrombophilia.ResultsNinety-five patients with CVEs and 41 contro...
Source: Frontiers in Neurology - March 14, 2023 Category: Neurology Source Type: research
Microbubble signal and trial of org in acute stroke treatment (TOAST) classification in ischemic stroke
Right-to-left shunt (RLS) through a patent foramen ovale (PFO) is likely associated with ischemic stroke. Many studies have attempted to demonstrate the association between RLS and ischemic stroke. However, information on the association between the degree of RLS and the subtypes of ischemic stroke categorized by the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification is lacking.
Source: Journal of the Neurological Sciences - April 20, 2018 Category: Neurology Authors: Chan-Hyuk Lee, Hyun Goo Kang, Ji Sung Lee, Han Uk Ryu, Seul-Ki Jeong Source Type: research
Patent foramen ovale increases stroke risk in older people
Patent foramen ovale increases stroke risk in older people, Published online: 27 July 2018; doi:10.1038/s41582-018-0050-7Patent foramen ovale (PFO) is prevalent among young patients with cryptogenic stroke, and PFO closure reduces the risk of recurrent stroke in these individuals. A new study confirms that PFO is also frequent in patients with cryptogenic stroke aged >60 years, but the optimal management of such patients remains unresolved.
Source: Nature Reviews Neurology - July 27, 2018 Category: Neurology Authors: Heinrich P. Mattle Jeffrey L. Saver Source Type: research
