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Condition: Pancreatitis
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Total 58 results found since Jan 2013.
Updates in Drug Treatment of Severe Hypertriglyceridemia
AbstractPurpose of ReviewTo provide an insight into the new pharmacological options for the treatment of severe hypertriglyceridemia (sHTG).Recent FindingssHTG is difficult to treat. The majority of the traditional pharmacological agents available have limited success in both robustly decreasing triglyceride levels and/or in reducing the incidence of acute pancreatitis (AP), the most severe complication of sHTG. Therapeutic options with novel mechanisms of action have been developed, such as antisense oligonucleotides (ASO) and small interfering RNA (siRNA) targetingAPOC3 andANGPTL3. The review discusses also 2 abandoned d...
Source: Current Atherosclerosis Reports - August 29, 2023 Category: Cardiology Source Type: research
Primary disorders of lipid metabolism: their place in current dyslipidemia guidelines and treatment innovations
This article describes the relevance of new data for low density lipoprotein-effective therapy: inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), adenosine triphosphate (ATP) citrate lyase with bempedoic acid, and ANGPTL3 with special consideration of primary lipid metabolism disorders, which are insufficiently taken into account, or not taken into account at all, in current guidelines. This is due to their apparently low prevalence rate and thus the lack of large outcome studies. The authors also discuss the consequences of increased lipoprotein (a), which cannot be sufficiently reduced until the ongoin...
Source: Atherosclerosis - June 6, 2023 Category: Cardiology Authors: G Klose I Gouni-Berthold W M ärz Source Type: research
Cofilin activation in pancreatic acinar cells plays a pivotal convergent role for mediating CCK-stimulated enzyme secretion and growth
Conclusion: These results support the conclusion that cofilin activation plays a pivotal convergent role for various cell signaling cascades in CCK mediated growth/enzyme secretion in pancreatic acini.
Source: Frontiers in Physiology - April 17, 2023 Category: Physiology Source Type: research
Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1 α pathway
Free Radic Res. 2023 Jan 2:1-15. doi: 10.1080/10715762.2022.2163244. Online ahead of print.ABSTRACTSevere acute pancreatitis (SAP) is an inflammatory disorder of the exocrine pancreas associated with high morbidity and mortality. SAP has been proven to trigger mitochondria dysfunction in the pancreas. We found that Deoxyarbutin (dA) recovered impaired mitochondrial function. High-temperature requirement protein A2 (HtrA2), a mitochondrial serine protease upstream of PGC-1α, is charge of quality control in mitochondrial homeostasis. The molecular docking study indicated that there was a potential interaction between dA and...
Source: Free Radical Research - January 2, 2023 Category: Research Authors: Yangying Li Yuda Zhu Shiyi Li Yuman Dong Chengyu Wan Xiuxian Yu Guang Xin Zeliang Wei Fan Li Yilan Wang Kun Zhang Qingqiu Chen Cuicui Zhang E Wen Hai Niu Wen Huang Source Type: research
Safety and efficacy of therapies for chylomicronemia
Expert Rev Clin Pharmacol. 2022 Jun 28. doi: 10.1080/17512433.2022.2094768. Online ahead of print.ABSTRACTINTRODUCTION: Primary chylomicronemia is characterized by pathological accumulation of chylomicrons in plasma causing severe hypertriglyceridemia, typically >10 mmol/L (>875 mg/dL). Patients with the ultra-rare familial chylomicronemia syndrome (FCS) subtype completely lack lipolytic capacity and respond minimally to traditional triglyceride-lowering therapies. The mainstay of treatment is a low-fat diet, which is difficult to follow and compromises quality of life. New therapies are being developed primarily to ...
Source: Pharmacological Reviews - June 28, 2022 Category: Drugs & Pharmacology Authors: Isabel Shamsudeen Robert A Hegele Source Type: research
