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Condition: Pain
Drug: Melatonin
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Total 119 results found since Jan 2013.
Melatonin as preemptive analgesic for intraoperative pain
This study evaluates the efficacy of using melatonin and ketorolac for pain prevention during open-flap debridement surgery. This prospective randomized controlled trial was performed in patients who presented with chronic periodontitis after non-surgical periodontal therapy, requiring flap surgery. Group 1: Flap surgery following non-surgical periodontal therapy after one month with no oral administration of analgesic. Group 2: Flap surgery following non-surgical periodontal therapy after one month with oral administration of Ketorolac 400mg one hour prior to the surgery. Group 3: Flap surgery following non-surgical perio...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Chanchal Katariya Sankari Malaiappan Source Type: research
Melatonin Supplementation for Cancer-Related Fatigue in Patients With Early Stage Breast Cancer Receiving Radiotherapy: A Double-Blind Placebo-Controlled Trial
CONCLUSIONS: In this double-blind placebo-controlled phase III trial, melatonin did not prevent or significantly improve fatigue and other symptoms in patients with early stage breast cancer undergoing RT. The analysis, showing little evidence of an effect, at mid-recruitment, assured early termination of the trial.PMID:37699115 | DOI:10.1093/oncolo/oyad250
Source: The Oncologist - September 12, 2023 Category: Cancer & Oncology Authors: Nitai D Mukhopadhyay Adam Khorasanchi Sudeep Pandey Srinidhi Nemani Gwendolyn Parker Xiaoyan Deng Douglas W Arthur Alfredo Urdaneta Egidio Del Fabbro Source Type: research
Perioperative Anxiolysis and Analgesic Effect after Premedication with Melatonin and Pregabalin in Total Hip Arthroplasty under Spinal Anaesthesia: A Prospective Comparative Trial
CONCLUSIONS: Pregabalin was found better for perioperative anxiolysis, post-operative analgesia and for prolongation of duration of spinal anaesthesia when compared to melatonin.PMID:37694243 | PMC:PMC10492595 | DOI:10.4103/abr.abr_323_22
Source: Biomed Res - September 11, 2023 Category: Research Authors: Akash Mishra Vinod Kumar Srivastava Ravi Prakash Neel Kamal Mishra Jyotsna Agarwal Shruti Kabi Source Type: research
Pediatric hypnic headache: a systematic review
DiscussionFurther evaluation of the clinical features of HH in children is needed. The development of specific diagnostic criteria for pediatric cases could improve diagnostic rates and enhance the management of children with HH.
Source: Frontiers in Neurology - August 11, 2023 Category: Neurology Source Type: research
Toll-like Receptor 2-Melatonin Feedback Loop Regulates the Activation of Spinal NLRP3 Inflammasome in Morphine-Tolerant Rats
CONCLUSION: In this study, we directly demonstrate a TLR2-melatonin negative feedback loop regulating microglia and NLRP3 inflammasome activation during the development of morphine tolerance.PMID:37561258 | DOI:10.1007/s11064-023-03998-6
Source: Neurochemical Research - August 10, 2023 Category: Neuroscience Authors: Xiaoling Peng Jihong Wang Zheng Li Xiaoqian Jia Anqi Zhang Jie Ju Volker Eulenburg Feng Gao Source Type: research
Melatonin protects against ketorolac induced gastric mucosal toxic injuries through molecular mechanism associated with the modulation of Arylakylamine N-Acetyltransferase (AANAT) activity
This study aims at exploring the role of gastric endogenous MT level and it's metabolizing enzyme AANAT, at the onset of ketorolac mediated toxicities in the gastric mucosa. Gastric mucosal damage was induced in experimental rats by oral administration of graded doses of KT, where 50 mg/kg b.w. of KT was observed to incur maximum gastric lesions. However, gastric damages were found to be protected in rats, pre-treated with 60 mg/kg b.w. of MT. Post-sacrifice, mean ulcer index, oxidative status, total melatonin levels and enzyme activities associated with MT biosynthesis and catabolism were estimated. The results reveal tha...
Source: Chemico-Biological Interactions - June 22, 2023 Category: Molecular Biology Authors: Romit Majumder Madhuri Datta Adrita Banerjee Debasish Bandyopadhyay Aindrila Chattopadhyay Source Type: research
Effects of Melatonin Alone or Associated with Acyclovir on the Suppressive Treatment of Recurrent Genital Herpes: A Prospective, Randomized, and Double-Blind Study
CONCLUSION: Our data suggest that melatonin may be an option for the suppressive treatment of recurrent genital herpes.PMID:37189706 | PMC:PMC10135732 | DOI:10.3390/biomedicines11041088
Source: Herpes - May 16, 2023 Category: Infectious Diseases Authors: Cristiane Lima Roa Jos é Cipolla-Neto Russel J Reiter Iara Moreno Linhares Ana Paula Lepique Lana Maria de Aguiar Isadora Braga Seganfredo Edson Santos Ferreira-Filho Sebasti ão Freitas de Medeiros Edmund Chada Baracat Jos é Maria Soares-Júnior Source Type: research
