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AGA Clinical Practice Update on Alpha-Gal Syndrome for the GI Clinician: Commentary
Alpha-gal syndrome causes an IgE-mediated reaction hours after eating beef, pork, other mammalian meat, or mammalian-derived products.1 Although the allergy was first described in patients with anaphylaxis and urticaria, gastrointestinal (GI) alpha-gal is a phenotype that increasingly is recognized and manifests with GI symptoms such as abdominal pain, diarrhea, nausea, and vomiting without predominant skin, respiratory, or circulatory symptoms.2 –9 It is important for gastroenterologists to be aware of this condition and to be capable of diagnosing and treating it in a timely manner.
Source: Clinical Gastroenterology and Hepatology - February 24, 2023 Category: Gastroenterology Authors: Sarah K. McGill, Jana G. Hashash, Thomas A. Platts-Mills Tags: Clinical Practice Update Source Type: research

Food Allergies and Alpha-gal Syndrome for the Gastroenterologist
AbstractPurpose of ReviewFood allergies are typically not considered as a cause of gastrointestinal (GI) distress without additional allergic symptoms, apart from celiac disease and eosinophilic esophagitis. However, recent reports of patients with alpha-gal syndrome who presented with GI-only symptoms like abdominal pain, vomiting, and diarrhea challenge this paradigm. Alpha-gal syndrome is an IgE-mediated allergy characterized by delayed reactions after eating mammalian meat or mammalian-derived products that contain galactose-alpha-1,3-galactose (alpha-gal). The purpose of this review is to discuss our current understan...
Source: Current Gastroenterology Reports - January 27, 2023 Category: Gastroenterology Source Type: research

Significance of 5-Aminosalicylic Acid Intolerance in the Clinical Management of Ulcerative Colitis
Background: Two major types of 5-aminosalicylic acid (5-ASA)-containing preparations, namely, mesalazine/5-ASA and sulfasalazine (SASP), are currently used as first-line therapy for ulcerative colitis. Recent reports show that optimization of 5-ASA therapy is beneficial for both patient outcomes and healthcare costs. Although 5-ASA and SASP have good efficacy and safety profiles, clinicians occasionally encounter patients who develop 5-ASA intolerance.Summary: The most common symptoms of acute 5-ASA intolerance syndrome are exacerbation of diarrhea, fever, and abdominal pain. Patients who discontinue 5-ASA therapy because ...
Source: Digestion - November 10, 2022 Category: Gastroenterology Source Type: research

Neonatal Antibiotics and Food Allergy Are Associated With FGIDs at 4–6 Years of Age
Conclusion: Antibiotics during the first week of life resulted in a higher risk for functional abdominal pain at 4–6 years. Furthermore, food allergy was associated with IBS and abdominal migraine at 4–6years.
Source: Journal of Pediatric Gastroenterology and Nutrition - June 1, 2022 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Role of Glucose Breath Test for Small Intestinal Bacterial Overgrowth in Children and Adolescents With Functional Abdominal Pain Disorders in Korea
CONCLUSIONS: SIBO is not uncommon in children and adolescents with FAPDs. Among children aged above 12 years and diagnosed with FAPDs, SIBO is a suspected clinical target for treatment to relieve intestinal symptoms. A further study to investigate the association between intestinal bacteria and history of allergy is needed.PMID:34980690 | PMC:PMC8748850 | DOI:10.5056/jnm20231
Source: Journal of Neurogastroenterology and Motility - January 4, 2022 Category: Gastroenterology Authors: Jin Lee Chang-Nyol Paik Dae Bum Kim Ji Min Lee Yeon-Ji Kim Sik Kyung Choi Yeon Jong Cho Source Type: research

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