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Specialty: Neuroscience
Condition: Hypertension

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Total 232 results found since Jan 2013.

Clinical and radiological assessment of cerebral hemodynamics after cranioplasty for decompressive craniectomy – A Clinical study
Conclusion Cranioplasty influences the cerebral hemodynamics after cranioplasty and has a positive correlation on the functional outcome and cerebral blood flow in the MCA territory.
Source: Journal of Clinical Neuroscience - June 29, 2017 Category: Neuroscience Source Type: research

Prognostic value of peripheral leukocyte counts and plasma glucose in intracerebral haemorrhage
Conclusion These results suggest that a logistic regression model using low admission glucose and low total leukocyte count may be markers of better prognosis in acute haemorrhagic stroke with a differential effect between sexes.
Source: Journal of Clinical Neuroscience - June 12, 2017 Category: Neuroscience Source Type: research

Changing paradigm in the management of elderly patients with intracranial aneurysms: An institutional review
Publication date: Available online 7 June 2017 Source:Journal of Clinical Neuroscience Author(s): Oleg Y. Chernyshev, Shyamal C. Bir, Tanmoy K. Maiti, Devi Prasad Patra, Cesar Liendo, Hugo Cuellar, Alireza Minagar, Anil Nanda Optimal treatment of intracranial aneurysms (IAs) in elderly patients has not yet been well established. We have investigated the clinical and radiological outcomes and predictors of unfavorable outcome of IAs in elderly patients. Radiological and clinical data of 85 elderly patients from 2010 through 2015 were retrospectively reviewed. Significant differences between the groups were determined by a ...
Source: Journal of Clinical Neuroscience - June 7, 2017 Category: Neuroscience Source Type: research

Post-stroke treatment with 17 β-estradiol exerts neuroprotective effects in both normotensive and hypertensive rats
Publication date: 21 April 2017 Source:Neuroscience, Volume 348 Author(s): Wendy Stoop, Deborah De Geyter, Sofie Verachtert, Sofie Brouwers, Peggy Verdood, Jacques De Keyser, Ron Kooijman Although ischemic stroke is a major cause of death worldwide and the predominant cause of acquired disability, the only effective drug therapy that has been developed thus far is reperfusion by tissue plasminogen activator. Since most patients do not qualify for this treatment, new methods have to be developed. It is well known that estradiol (E2) exerts neuroprotective effects in different models of cerebral ischemia, but post-stroke tr...
Source: Neuroscience - March 15, 2017 Category: Neuroscience Source Type: research

Clinical predictors for favorable outcomes from endovascular recanalization in wake-up stroke
Conclusions The results of this study suggest that the SRDT is an independent predictor of both an improvement of NIHSS score and a good functional outcome in endovascular recanalization for WUS patients.
Source: Journal of Clinical Neuroscience - March 1, 2017 Category: Neuroscience Source Type: research

Ketamine Therapy for Treatment-resistant Depression in a Patient with Multiple Sclerosis: A Case Report
Conclusion—Ketamine may be an alternative treatment for resistant depression and may have a special use in patients with multiple sclerosis. Introduction Depression is a frequent finding in patients with multiple sclerosis (MS), with the lifetime prevalence rates for major depressive disorder (MDD) ranging from 36 to 54 percent, more than twice of that in the general population.[1] Even with advances in pharmacological options for treating depression, an estimated 33 to 66 percent of patients with MDD in the general population do not respond to the first antidepressant, and a reported 15 to 33 percent of patients do not ...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Depression Multiple Sclerosis Neurology Psychiatry Psychopharmacology Electroconvulsive therapy Ketamine major depressive disorder treatment-resistant depression Source Type: research

Sex differences in stroke across the lifespan: The role of T lymphocytes
Publication date: Available online 25 January 2017 Source:Neurochemistry International Author(s): Javiera Bravo-Alegria, Louise D. McCullough, Fudong Liu Stroke is a sexually dimorphic disease. Ischemic sensitivity changes throughout the lifespan and outcomes depend largely on variables like age, sex, hormonal status, inflammation, and other existing risk factors. Immune responses after stroke play a central role in how these factors interact. Although the post-stroke immune response has been extensively studied, the contribution of lymphocytes to stroke is still not well understood. T cells participate in both innate and...
Source: Neurochemistry International - January 25, 2017 Category: Neuroscience Source Type: research

Induced Hypothermia in Neurocritical Care: A Review
This article will review indications for IH administration, methods of providing IH, nursing responsibilities, and identifying and/or managing complications.
Source: Journal of Neuroscience Nursing - January 7, 2017 Category: Neuroscience Tags: Clinical Nursing Focus Source Type: research

Structural and functional brain alterations in a murine model of Angiotensin II ‐induced hypertension
Abstract Hypertension is a main risk factor for the development of cerebral small vessel disease (cSVD) – a major contributor to stroke and the most common cause of vascular dementia. Despite the increasing socioeconomic importance arising from cSVD, currently only a few specific treatment strategies with proven efficacy are known. Fundamental to the lack of specific treatments is poor understanding of the disease pathogenesis and a lack of appropriate animal models resembling all symptoms of the human disease. However, chronic hypertensive rat models have been shown to bear similarities to most key features of cSVD. Des...
Source: Journal of Neurochemistry - December 20, 2016 Category: Neuroscience Authors: Anja Meissner, Jens Minnerup, Guadalupe Soria, Anna M Planas Tags: Original Article Source Type: research

Sex differences in neuroinflammation and neuroprotection in ischemic stroke
Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke‐related disability. Stroke has dropped to the fifth leading cause of death in men, but remains the third in women. This review discusses sex differences in common stroke risk factors, the efficacy of stroke prevention therapies, acute treatment responses, and post‐stroke recovery in clinical populations. Women have an increased lifetime risk of stroke compared to men, largely due to a s...
Source: Journal of Neuroscience Research - November 6, 2016 Category: Neuroscience Authors: Monica S. Spychala, Pedram Honarpisheh, Louise D. McCullough Tags: Review Source Type: research

Influence of sleep duration on cortical oxygenation in elderly individuals
ConclusionsSleep duration may be an important factor that influences cortical oxygenation in the elderly population.
Source: Psychiatry and Clinical Neurosciences - September 30, 2016 Category: Neuroscience Authors: Kazuko Kato, Seiko Miyata, Motoo Ando, Hiroki Matsuoka, Fumihiko Yasuma, Kunihiro Iwamoto, Naoko Kawano, Masahiro Banno, Norio Ozaki, Akiko Noda Tags: Regular Article Source Type: research

Pituitary aspergillus infection
We report a case of Aspergillus infection involving the pituitary gland and sellar region discovered in a 74-year-old man. The patient had a history of hypertension, chronic renal disease, autoimmune hemolytic anemia and presented with right eye pain, headaches and worsening hemiparesis. Imaging studies revealed a right internal carotid artery occlusion and an acute right pontine stroke along with smaller infarcts in the right middle cerebral artery distribution. Clinically, the patient was thought to have vasculitis. An infectious etiology was not identified. He developed respiratory distress and died. At autopsy, necroti...
Source: Journal of Clinical Neuroscience - May 29, 2016 Category: Neuroscience Source Type: research

Role of serum ‐ and glucocorticoid‐inducible kinases in stroke
Abstract Increased expression of serum‐ and glucocorticoid‐inducible kinase 1 (SGK1) can be induced by stress and growth factors in mammals, and plays an important role in cancer, diabetes, and hypertension. A recent work suggested that SGK1 activity restores damage in a stroke model. To further investigate the role of SGKs in ischemic brain injury, we examined how SGK inhibitors influence stroke outcome in vivo and neurotoxicity in vitro. Infarct volumes were compared in adult mice with middle cerebral artery occlusion, followed by 24 h reperfusion, in the absence or presence of SGK inhibitors. Neurotoxicity assay,...
Source: Journal of Neurochemistry - May 24, 2016 Category: Neuroscience Authors: Koichi Inoue, Tiandong Leng, Tao Yang, Zhao Zeng, Takatoshi Ueki, Zhi ‐Gang Xiong Tags: Original Article Source Type: research

Methylenetetrahydrofolate reductase C677T polymorphism, hypertension and risk of stroke: a prospective, nested case-control study
10.1080/00207454.2016.1183126Shanqun Jiang
Source: International Journal of Neuroscience - May 15, 2016 Category: Neuroscience Authors: Shanqun JiangJianping LiYan ZhangScott A. VennersGenfu TangYu WangZhiping LiXiping XuBinyan WangYong Huo Source Type: research