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Specialty: Chemistry
Condition: Hypertension

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Total 54 results found since Jan 2013.

The emerging role of microRNA in stroke.
Abstract MicroRNAs (miRNAs) are small non-coding RNAs approximately 22 nucleotides in length that play a pivotal role in post-transcriptional gene regulation by binding to complementary sites in the 3'-untranslated region of messenger RNAs. In the past decade, their role in several human diseases, from cancer to cardiovascular disease, has been established by a wealth of evidence. Stroke is responsible for 10% of deaths worldwide and is one of the leading causes of disability. MiRNAs are involved in stroke risk factors including hypertension, atherosclerosis, atrial fibrillation, diabetes and dyslipidemia. The rol...
Source: Current Topics in Medicinal Chemistry - May 31, 2013 Category: Chemistry Authors: Koutsis G, Siasos G, Spengos K Tags: Curr Top Med Chem Source Type: research

Essential Hypertension, Cerebral White Matter Pathology And Ischemic Stroke.
Abstract Stroke is one of the most-frequent cause of death and the number one cause of disability worldwide. Different mechanisms are related to the pathogenesis of stroke involving multiple biological systems, which are often connected among them. Besides age, hypertension is the most important risk factor for stroke and may also predispose to the development of more subtle cerebral damage based on arteriolar narrowing or pathological microvascular changes. Age and high blood pressure are responsible for silent structural and functional cerebral changes leading to white matter lesions and cognitive impairment. Th...
Source: Current Medicinal Chemistry - December 27, 2013 Category: Chemistry Authors: Sierra C Tags: Curr Med Chem Source Type: research

Ιmmunity, Vascular Aging, and Stroke
Curr Med Chem. 2022 Jan 3. doi: 10.2174/0929867329666220103101700. Online ahead of print.ABSTRACTStroke is one of the most devastating manifestations of cardiovascular disease. Growing age, arterial hypertension, and atherosclerosis are identified as independent risk factors for stroke, primarily due to structural and functional alterations in the cerebrovascular tree. Recent data from in vitro and clinical studies have suggested that the immune system influences atherosclerosis, promoting vascular stiffness and vascular aging and contributing to ischemic stroke, intracranial haemorrhage and microbleeds, white matter disea...
Source: Current Medicinal Chemistry - January 4, 2022 Category: Chemistry Authors: Anna-Maria Louka Dimitrios Sagris George Ntaios Source Type: research

Inflammatory Molecular Mediators and Pathways Involved in Vascular Aging and Stroke: A Comprehensive Review
Curr Med Chem. 2021 Sep 1. doi: 10.2174/0929867328666210901122359. Online ahead of print.ABSTRACTThere is an increase in the incidence of cardiovascular diseases with aging and it is one of the leading causes of death worldwide. The main cardiovascular pathologies include atherosclerosis, stroke, myocardial infarction, hypertension and stroke. Chronic inflammation is one of the significant contributors to the age-related vascular diseases. Therefore, it is important to understand the molecular mechanisms of the persistent inflammatory conditions occurring in the blood vessels as well as the signaling pathways involved. Her...
Source: Current Medicinal Chemistry - September 7, 2021 Category: Chemistry Authors: Amro M Soliman Srijit Das Pasuk Mahakkanukrauh Source Type: research

The Role of Nicotinamidephosphoribosyltransferase in Cerebral Ischemia.
Abstract As recombinant tissue plasminogen activator is the only drug approved for the clinical treatment of acute ischemic stroke, there is an urgent unmet need for novel stroke treatments. Endogenous defense mechanisms against stroke may hold the key to new therapies for stroke. A large number of studies suggest that nicotinamidephosphoribosyl-transferase (NAMPT) is an attractive candidate to improve post-stroke recovery. NAMPT is a multifunctional protein and plays important roles in immunity, metabolism, aging, inflammation, and stress responses. NAMPT exists in both the intracellular and extracellular space. ...
Source: Current Topics in Medicinal Chemistry - June 10, 2015 Category: Chemistry Authors: Chen X, Zhao S, Song Y, Shi Y, Leak RK, Cao G Tags: Curr Top Med Chem Source Type: research

Molecules, Vol. 26, Pages 811: Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis
Changwei Liu Carotid artery stenosis (CAS) is an atherosclerotic disease characterized by a narrowing of the artery lumen and a high risk of ischemic stroke. Risk factors of atherosclerosis, including smoking, hypertension, hyperglycemia, hyperlipidemia, aging, and disrupted circadian rhythm, may potentiate atherosclerosis in the carotid artery and further reduce the arterial lumen. Ischemic stroke due to severe CAS and cerebral ischemic/reperfusion (I/R) injury after the revascularization of CAS also adversely affect clinical outcomes. Melatonin is a pluripotent agent with potent anti-inflammatory, anti-oxidative, an...
Source: Molecules - February 4, 2021 Category: Chemistry Authors: Rui Zhang Leng Ni Xiao Di Baitao Ma Shuai Niu Zhihua Rong Changwei Liu Tags: Review Source Type: research

Molecules, Vol. 28, Pages 1021: Cyclic Glycine-Proline (cGP) Normalises Insulin-Like Growth Factor-1 (IGF-1) Function: Clinical Significance in the Ageing Brain and in Age-Related Neurological Conditions
ep Singh-Mallah Insulin-like growth factor-1 (IGF-1) function declines with age and is associated with brain ageing and the progression of age-related neurological conditions. The reversible binding of IGF-1 to IGF binding protein (IGFBP)-3 regulates the amount of bioavailable, functional IGF-1 in circulation. Cyclic glycine-proline (cGP), a metabolite from the binding site of IGF-1, retains its affinity for IGFBP-3 and competes against IGF-1 for IGFBP-3 binding. Thus, cGP and IGFBP-3 collectively regulate the bioavailability of IGF-1. The molar ratio of cGP/IGF-1 represents the amount of bioavailable and functional IG...
Source: Molecules - January 19, 2023 Category: Chemistry Authors: Jian Guan Fengxia Li Dali Kang Tim Anderson Toni Pitcher John Dalrymple-Alford Paul Shorten Gagandeep Singh-Mallah Tags: Review Source Type: research

Micrornas In Cardiovascular Therapeutics.
Abstract Recent research reveals the crucial role microRNAs (miRNAs) in the pathogenesis and progression of many pathological conditions, including cardiovascular diseases. It is widely documented that miRNAs represent critical regulators of cardiovascular function and participate in almost all aspects of cardiovascular biology. In particular, they are involved in several pathophysiological pathways of various manifestations of cardiovascular disease, such as coronary artery disease, heart failure, stroke, diabetes mellitus, arterial hypertension and cardiac arrhythmias. In the present article we review the availa...
Source: Current Topics in Medicinal Chemistry - May 31, 2013 Category: Chemistry Authors: Siasos G, Tousoulis D, Tourikis P, Mazaris S, Zakynthinos G, Oikonomou E, Kokkou E, Kollia C, Stefanadis C Tags: Curr Top Med Chem Source Type: research

MicroRNAs In Arterial Hypertension.
Abstract Arterial hypertension is an epidemic currently affecting almost a billion people worldwide. The consequences from high blood pressure vary, from peripheral arterial disease and chronic kidney failure to acute myocardial infarction and stroke. MicroRNAs (miRNAs) are small non-coding RNA molecules comprised of 22-26 nucleotides and provide post-transcriptional protein expression regulation. The many biological processes in which they are implicated, such as cell proliferation, apoptosis, metabolism, cell differentiation and morphogenesis confirms the functional significance of miRNAs. It has been found that...
Source: Current Topics in Medicinal Chemistry - May 31, 2013 Category: Chemistry Authors: Synetos A, Toutouzas K, Stathogiannis K, Latsios G, Tsiamis E, Tousoulis D, Stefanadis C Tags: Curr Top Med Chem Source Type: research

Mechanistic insights into mode of action of a potent natural antagonist of orexin receptor-1 by means of high throughput screening and molecular dynamics simulations.
Abstract Insomnia is one of the most common clinical problems being faced by people all over the world. It adversely affects the routine life of these patients giving rise to even other health issues like hypertension, diabetes, obesity, depression, heart attack, and stroke. Orexin receptor-1 (OX1R), a noteworthy drug target, when inhibited can promote sleepiness in people suffering from such conditions. OX1R is a G-protein coupled receptor which is conserved throughout the mammalian species and is located primarily in hypothalamus and locus coeruleus. The present study aims at identifying potent natural-origin in...
Source: Combinatorial Chemistry and High Throughput Screening - October 3, 2013 Category: Chemistry Authors: Dhanjal JK, Grover S, Paruthi P, Sharma S, Grover A Tags: Comb Chem High Throughput Screen Source Type: research

Obesity, Hypertension and Hypercholesterolemia as Risk Factors for Atherosclerosis Leading to Ischemic Events.
Abstract Atherosclerosis is a widespread disease of the arterial system that is generated by injury to the vasculature due to hypercholesterolemia, hypertension and inflammatory diseases. In the current review, we discuss the role of different risk factors, including obesity, hypertension and hypercholesterolemia in atherosclerosis, which may ultimately lead to either cardiovascular or cerebral complication. Inflammation plays a pivotal role in conjunction with obesity, hypertension and hypercholesterolemia in the etiology of atherosclerosis. We discuss the role of inflammation with regards to reactive oxygen spec...
Source: Current Medicinal Chemistry - December 27, 2013 Category: Chemistry Authors: Mia-Jeanne VR, Pretorius E Tags: Curr Med Chem Source Type: research

LOX-1 in atherosclerotic disease.
Abstract Oxidized low-density lipoprotein (LDL) exhibits various biological activities and accumulates in atheromas. LOX-1 (lectin-like oxidized LDL receptor) is the receptor that mediates oxidized LDL activity in vascular endothelial cells. Activation of LOX-1 results in oxidized LDL-induced endothelial dysfunction and hyperlipidemia-induced vascular lipid deposition. We hypothesized that LOX-1 is a candidate risk factor beyond LDL cholesterol (LDLC) and developed a novel assay to quantify LOX-1 ligand containing apoB (LAB). In men from the United States, serum LAB showed a significant positive association with c...
Source: International Journal of Clinical Chemistry - November 22, 2014 Category: Chemistry Authors: Sawamura T, Wakabayashi I, Okamura T Tags: Clin Chim Acta Source Type: research