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Condition: Hypertension
Procedure: Cardiac Catheterization
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Total 178 results found since Jan 2013.
Metalloproteinases and Their Inhibitors Are Associated with Pulmonary Arterial Stiffness and Ventricular Function in Pediatric Pulmonary Hypertension
Am J Physiol Heart Circ Physiol. 2021 Jun 4. doi: 10.1152/ajpheart.00750.2020. Online ahead of print.ABSTRACTDisturbed balance between matrix metalloproteinases (MMPs) and their respective tissue inhibitors (TIMPs) is a well-recognized pathophysiologic component of pulmonary arterial hypertension (PAH). Both classes of proteases have been associated with clinical outcomes as well as with specific pathologic features of ventricular dysfunction and pulmonary arterial remodeling. The purpose of this study was to evaluate the circulating levels of MMPs and TIMPs in children with PAH undergoing the same day cardiac MRI and righ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - June 4, 2021 Category: Physiology Authors: Michal Schafer D Dunbar Ivy Kathleen Nguyen Katie L Boncella Benjamin S Frank Gareth J Morgan Kathleen Miller-Reed Uyen Truong Kelley L Colvin Michael E Yeager Source Type: research
Cutaneous Iontophoresis of Vasoactive Medications in Patients with Scleroderma ‐ Associated Pulmonary Arterial Hypertension
ConclusionsPatients with SSc-PAH have a lower cutaneous microvascular response to a prostacyclin analog treprostinil and the sGC activator A-350619 when compared with patients with SSc and no evidence of PH on screening tests, presumably due to a peripheral reduction in prostacyclin receptor expression and nitric oxide bioavailability.
Source: Microcirculation - November 6, 2021 Category: Research Authors: Sami Al Abdi,
Allaa Almoushref,
Tawfeq Naal,
Celia Melillo,
Kulwant S. Aulak,
Mostafa K. Ahmed,
Soumya Chatterjee,
Kristin Highland,
Raed A. Dweik,
Adriano R. Tonelli Tags: ORIGINAL ARTICLE Source Type: research
Cutaneous iontophoresis of vasoactive medications in patients with scleroderma ‐associated pulmonary arterial hypertension
ConclusionsPatients with SSc-PAH have a lower cutaneous microvascular response to a prostacyclin analog treprostinil and the sGC activator A-350619 when compared with patients with SSc and no evidence of PH on screening tests, presumably due to a peripheral reduction in prostacyclin receptor expression and nitric oxide bioavailability.
Source: Microcirculation - November 17, 2021 Category: Research Authors: Sami Al Abdi,
Allaa Almoushref,
Tawfeq Naal,
Celia A. Melillo,
Kulwant S. Aulak,
Mostafa K. Ahmed,
Soumya Chatterjee,
Kristin B. Highland,
Raed A. Dweik,
Adriano R. Tonelli Tags: ORIGINAL ARTICLE Source Type: research
Patient-Specific Computational Analysis of Hemodynamics in Adult Pulmonary Hypertension
Ann Biomed Eng. 2021 Nov 19. doi: 10.1007/s10439-021-02884-y. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is a progressive disease characterized by elevated pressure and vascular resistance in the pulmonary arteries. Nearly 250,000 hospitalizations occur annually in the US with PH as the primary or secondary condition. A definitive diagnosis of PH requires right heart catheterization (RHC) in addition to a chest computed tomography, a walking test, and others. While RHC is the gold standard for diagnosing PH, it is invasive and posseses inherent risks and contraindications. In this work, we characterized the ...
Source: Annals of Biomedical Engineering - November 20, 2021 Category: Biomedical Engineering Authors: Narasimha R Pillalamarri Senol Piskin Sourav S Patnaik Srinivas Murali Ender A Finol Source Type: research
Echocardiographic Biventricular Coupling Index to Predict Pre-Capillary Pulmonary Hypertension
In this study, the novel echocardiographic Biventricular Coupling Index (BCI), based on the ratio between Right Ventricular Stroke Work Index and left ventricular E/E ’ ratio, was tested for the discrimination of PH subtype using RHC as the comparator.
Source: Journal of the American Society of Echocardiography - February 10, 2022 Category: Cardiology Authors: Stefano Albani, Davide Stolfo, Ashwin Venkateshvaran, Vlad Chubuchny, Federico Biondi, Antonio De Luca, Francesco Lo Giudice, Emilio M. Pasanisi, Christina Petersen, Edoardo Air ò, Carolina Bauleo, Marco Ciardetti, Michele Coceani, Bruno Formichi, Jens S Tags: Clinical Investigations Source Type: research
