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Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Promising translatable pharmacological interventions for body weight management in individuals with severe mental illness - a narrative review
Expert Opin Pharmacother. 2023 Aug 31. doi: 10.1080/14656566.2023.2254698. Online ahead of print.ABSTRACTINTRODUCTION: Psychotropic medications, especially antipsychotics, have been consistently shown to cause weight gain in individuals with severe mental illness (SMI), a population inherently challenged with poor physical health. Consequently, compared to the general population, this contributes to an increased cardiometabolic burden, including the risk of type 2 diabetes, dyslipidemia, and hypertension. Furthermore, comorbid obesity leads to treatment nonadherence, decreased quality of life, and increased risk of relapse...
Source: Expert Opinion on Pharmacotherapy - September 1, 2023 Category: Drugs & Pharmacology Authors: Riddhita De Femin Prasad Nicolette Stogios Luisa Burin Bj ørn H Ebdrup Filip K Knop Margaret K Hahn Sri Mahavir Agarwal Source Type: research
Metformin and SGLT2i as First-line Combination Therapy in Type 2 Diabetes: A Real-world Study With a Focus on Ethnicity
Clin Ther. 2023 Aug 28:S0149-2918(23)00302-8. doi: 10.1016/j.clinthera.2023.07.026. Online ahead of print.ABSTRACTPURPOSE: Suboptimal glucose control early in the diagnosis of type 2 diabetes (T2D) is strongly associated with subsequent morbidity and mortality, termed the 'glycaemic legacy'. Additionally, it is known that Asian and Black individuals are at increased risk of T2D, and its associated complications compared to their White counterparts. However, ethnicity does not currently feature in the treatment algorithm of T2D, unlike in other cardiovascular disease states such as hypertension. We therefore sought to evalu...
Source: Clinical Therapeutics - August 30, 2023 Category: Drugs & Pharmacology Authors: Matthew Anson Sizheng Steven Zhao Hani Essa Philip Austin Gema Hern ández Ibarburu Gregory Y H Lip Uazman Alam Source Type: research
GAL3 Mediates Vascular Dysfunction in Obesity by Regulating NOX1
CONCLUSIONS: Deletion of GAL3 normalizes microvascular endothelial function in obese db/db mice, likely through an NOX1-mediated mechanism. Pathological levels of GAL3, and in turn NOX1, are amenable to improvements in metabolic status, presenting a potential therapeutic target to ameliorate pathological cardiovascular consequences of obesity.PMID:37586054 | DOI:10.1161/ATVBAHA.123.319476
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 16, 2023 Category: Cardiology Authors: Caleb A Padgett R óbert K Bátori Andrew C Speese Cody L Rosewater Weston B Bush Cassandra C Derella Stephen B Haigh Hunter G Sellers Zachary L Corley Madison A West James D Mintz Brittany B Ange Ryan A Harris Michael W Brands David J R Fulton David W St Source Type: research
Metformin protects against pulmonary hypertension-induced right ventricular dysfunction in an age- and sex-specific manner independent of cardiac AMPK
Am J Physiol Heart Circ Physiol. 2023 Jun 30. doi: 10.1152/ajpheart.00124.2023. Online ahead of print.ABSTRACTRight ventricular (RV) function is the strongest predictor of survival in age-related heart failure as well as other clinical contexts in which aging populations suffer significant morbidity and mortality. However, despite the significance of maintaining RV function with age and disease, mechanisms of RV failure remain poorly understood and no RV-directed therapies exist. The anti-diabetic drug and AMP-activated protein kinase (AMPK) activator metformin protects against left ventricular dysfunction, suggesting card...
Source: American Journal of Physiology. Heart and Circulatory Physiology - June 30, 2023 Category: Physiology Authors: Benjamin D McNair Sydney M Polson Samantha K Shorthill Aykhan Yusifov Lori A Walker Mary C M Weiser-Evans Elizabeth J Kovacs Danielle R Bruns Source Type: research
