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Condition: Hypertension
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Total 229 results found since Jan 2013.

Evolution of blood pressure clinical practice guidelines: a personal perspective
Publication date: Available online 27 February 2019Source: Canadian Journal of CardiologyAuthor(s): Paul K. WheltonAbstractPrior to the second half of the 20th century, most clinical decision-making was based on expert opinion. By the 1960s, experience in actuarial and research cohort studies had provided strong evidence that blood pressure was an important risk factor for cardiovascular disease. The landmark 1967 and 1970 Veterans Administration Cooperative Study trials confirmed the value of antihypertensive drug therapy in preventing stroke, myocardial infarction, and heart failure in adults with a high level of diastol...
Source: Canadian Journal of Cardiology - February 27, 2019 Category: Cardiology Source Type: research

Sex-Related Differences in Patients Undergoing Thoracic Aortic Surgery: Evidence from the Canadian Thoracic Aortic Collaborative.
CONCLUSIONS: Women experience worse outcomes following thoracic aortic surgery with hypothermic circulatory arrest. Further investigation is required to better delineate which measures may reduce sex-related outcome differences following complex aortic surgery. PMID: 30755026 [PubMed - as supplied by publisher]
Source: Circulation - February 13, 2019 Category: Cardiology Authors: Chung J, Stevens LM, Ouzounian M, El-Hamamsy I, Bouhout I, Dagenais F, Cartier A, Peterson M, Boodhwani M, Guo MH, Bozinovski J, Yamashita MH, Lodewyks C, Atoui R, Bittira B, Payne D, Tarola C, Chu MWA, Canadian Thoracic Aortic Collaborative Tags: Circulation Source Type: research

Pulmonary artery elastic properties after balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension.
ConclusionsBPA improved total CPa in proportion to a decrease in PVR despite no improvement in local elastic properties of the treated PA segments.
Source: Canadian Journal of Cardiology - February 2, 2019 Category: Cardiology Source Type: research

Prothrombotic state in atrial fibrillation patients with 1 additional risk factor of the CHA2DS2-VASc score (beyond sex)
ConclusionsA prothrombotic state (increased thrombin generation, denser fibrin clots, impaired fibrinolysis, and endothelial injury) characterizes AF patients with one additional clinical stroke risk factor (beyond sex), with age 65-74 years being particularly associated with a prothrombotic indices.
Source: Canadian Journal of Cardiology - January 30, 2019 Category: Cardiology Source Type: research

Prevalence of heart attack and stroke and associated risk factors among Inuit in Canada: A comparison with the general Canadian population.
CONCLUSION: Inuit and the general Canadian population differ in cardiovascular health profiles. Further research is needed to characterize the health transition among Inuit, especially among the youth and female. PMID: 30578133 [PubMed - as supplied by publisher]
Source: International Journal of Hygiene and Environmental health - December 18, 2018 Category: Environmental Health Authors: Hu XF, Singh K, Kenny TA, Chan HM Tags: Int J Hyg Environ Health Source Type: research

Descriptive analysis of pharmacy services provided after community pharmacy screening
Conclusions Approximately one-third of participants received a pharmacy service within 3  months post-screening. Relatively large numbers of annual and follow-up medication reviews were delivered despite low eligibility for annual-only reviews and despite many missed opportunities for pharmacy service provision in at-risk patients. In-pharmacy screening may facilitate provision of some services, namely medication reviews, by providing opportunities to identify patients at-risk.
Source: International Journal of Clinical Pharmacy - November 26, 2018 Category: Drugs & Pharmacology Source Type: research

Another Chance for Medtronic ’s Renal Denervation Therapy
Medtronic has yet another chance to prove its renal denervation therapy can treat uncontrolled hypertension. The Dublin-based company has received FDA approval to begin a clinical trial to evaluate the Symplicity Spyral renal denervation system with patients on medication for high blood pressure. The ON MED Trial is a 2:1 randomized, sham-controlled study and will randomize up to 340 patients at 55 centers in the U.S., Japan, Europe, Australia and Canada. Patients will be followed out to three years. Primary safety endpoints will include major adverse events at one month and new renal artery stenosis at six months. The pri...
Source: MDDI - November 8, 2018 Category: Medical Devices Authors: Omar Ford Tags: Business Source Type: news

XANTUS-EL: A real-world, prospective, observational study of patients treated with rivaroxaban for stroke prevention in atrial fibrillation in Eastern Europe, Middle East, Africa and Latin America
ConclusionsXANTUS-EL confirmed low stroke and major bleeding rates in patients with NVAF from EEMEA and Latin America. The population was younger but with more heart failure and hypertension than XANTUS; stroke/SE rate was similar but major bleeding lower.
Source: The Egyptian Heart Journal - October 5, 2018 Category: Cardiology Source Type: research

Patterns of incidence rates of cardiac complications in patients with congenital heart disease
ConclusionsCardiac complications are frequent in congenital heart disease. Apart from perioperative stroke and complete heart block, incidence rates are low in childhood but the incidence increases during adult life. These data underscore the need of life-long follow up and may help for better allocation of resources maintaining follow-up.
Source: Canadian Journal of Cardiology - October 4, 2018 Category: Cardiology Source Type: research

Aerobic Training in Canadian Stroke Rehabilitation Programs
Conclusions: Most stroke rehabilitation programs across Canada include AT. People with severe physical impairment and those with cardiac, metabolic, and hemodynamic comorbidities may be excluded or not appropriately monitored during exercise. More detailed guidelines and training practices are needed to address these challenges. Video Abstract available for more insights from the authors (see Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A233).
Source: Journal of Neurologic Physical Therapy - October 1, 2018 Category: Physiotherapy Tags: Research Articles Source Type: research

Effects of Riociguat on Right Ventricular Remodelling in Chronic Thromboembolic Pulmonary Hypertension Patients: A Prospective Study
ConclusionsRiociguat treatment was associated with increased RV stroke volume index and trends for improvement in myocardial remodelling in patients with CTEPH. A larger clinical study is warranted to observe the therapeutic benefits of riociguat on RV remodelling.RésuméContexteLes effets du traitement par le riociguat sur le métabolisme, la perfusion et le débit du ventricule droit (VD) chez les patients atteints d’hypertension pulmonaire thromboembolique chronique (HPTC) sont inconnus. Dans la présente étude, nous analysons les changements aux ventriculaires droits associés au traitement par le riociguat.Méthod...
Source: Canadian Journal of Cardiology - August 29, 2018 Category: Cardiology Source Type: research

Aerobic Training in Canadian Stroke Rehabilitation Programs.
CONCLUSIONS: Most stroke rehabilitation programs across Canada include AT. People with severe physical impairment and those with cardiac, metabolic, and hemodynamic comorbidities may be excluded or not appropriately monitored during exercise. More detailed guidelines and training practices are needed to address these challenges.Video Abstract available for more insights from the authors (see Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A233). PMID: 30138234 [PubMed - as supplied by publisher]
Source: Physical Therapy - August 22, 2018 Category: Physiotherapy Authors: Nathoo C, Buren S, El-Haddad R, Feldman K, Schroeder E, Brooks D, Inness EL, Marzolini S Tags: J Neurol Phys Ther Source Type: research

Determining the Optimal Systolic Blood Pressure for Hypertensive Patients: A Network Meta-analysis
ConclusionsSBP <130 mmHg is associated with a lower risk of stroke and major adverse cardiovascular events. Further lowering to <120 mmHg can be considered to reduce stroke risk if the therapy is tolerated. Long-term SBP should not exceed 150 mmHg because of increased risk of myocardial infarction and cardiac deaths.
Source: Canadian Journal of Cardiology - August 10, 2018 Category: Cardiology Source Type: research

Invasive Hemodynamics and Rejection Rates in Patients With Cardiac Sarcoidosis After Heart Transplantation
ConclusionsPatients with CS have similar post-transplant hemodynamics as patients without CS, without evidence of right ventricular dysfunction or pulmonary hypertension. Neither significant rejection nor recurrence of sarcoid in the allograft was observed in this cohort of patients with CS. Survival is similar between patients with CS and those without CS. Heart transplant is a viable strategy in selected patients with CS with excellent outcomes.RésuméIntroductionLa transplantation cardiaque orthotopique (TCO) est de plus en plus utilisée lors d’insuffisance cardiaque terminale liée à une sarcoïdose cardiaque (SC)...
Source: Canadian Journal of Cardiology - July 24, 2018 Category: Cardiology Source Type: research

Stroke and Coronary Artery Disease Are Associated With Parkinson's Disease.
CONCLUSIONS: Our study suggested that stroke and CAD are associated with PD in two Chinese population-based cohorts, indicating a probable vascular component in the pathogenesis of PD. PMID: 30001757 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - July 13, 2018 Category: Neurology Authors: Li Q, Wang C, Tang H, Chen S, Ma J Tags: Can J Neurol Sci Source Type: research