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Specialty: Neurology
Condition: Subarachnoid Hemorrhage
Education: Study
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Total 1373 results found since Jan 2013.
More is less: Effect of ICF-based early progressive mobilization on severe aneurysmal subarachnoid hemorrhage in the NICU
DiscussionWe conclude that the ICF-based early progressive mobilization protocol is an effective and feasible intervention tool. For validity, more mobilization interventions might lead to less pneumonia, duration of mechanical ventilation and length of stay for patients with severe aSAH in the NICU, Moreover, it is necessary to pay attention over potential adverse events (especially line problems), although we did not find serious safety events.
Source: Frontiers in Neurology - December 14, 2022 Category: Neurology Source Type: research
Acute Symptomatic Seizure Associated With Chronic Antiseizure Medication Use After Stroke
Discussion
Chronic ASM use is highly associated with electrographic, rather than convulsive, ASyS. However, long-term ASM use is independently associated with PSE and its risk factors, including convulsive ASyS. With the ubiquity of stroke-related ASyS concerns in routine clinical practice, comparative effectiveness studies to guide ASM management are needed.
Source: Neurology Clinical Practice - December 13, 2022 Category: Neurology Authors: Byrnes, M., Chandan, P., Newey, C., Hantus, S., Punia, V. Tags: Research Article Source Type: research
Association of Gut Microbiome with Early Brain Injury After Subarachnoid Hemorrhage: an Experimental Study
AbstractThe occurrence of early brain injury (EBI) following subarachnoid hemorrhage (SAH) is crucial in the prognosis of SAH; however, no effective treatment for EBI has been developed. Gut microbiome (GM) composition influences the outcome of various diseases, including ischemic stroke. Here, we evaluated whether prior GM alteration could prevent EBI following SAH. We altered the GM of 7-week-old male rats by administering antibiotic-containing water for 2 weeks and performing fecal microbiome transplantation after antibiotic induction. Composition of the GM was profiled using 16S rRNA. We induced SAH by injecting bloo...
Source: Translational Stroke Research - December 9, 2022 Category: Neurology Source Type: research
Potential role of serum hypoxia-inducible factor 1alpha as a biomarker of delayed cerebral ischemia and poor clinical outcome after human aneurysmal subarachnoid hemorrhage: A prospective, longitudinal, multicenter, and observational study
ConclusionElevated serum HIF-lα levels after aSAH, in independent correlation with stroke severity, were independently associated with DCI and 6-month poor outcome, substantializing serum HIF-lα as a potential prognostic biomarker of aSAH.
Source: Frontiers in Neurology - December 8, 2022 Category: Neurology Source Type: research
Long Non-coding RNA H19 Promotes NLRP3-Mediated Pyroptosis After Subarachnoid Hemorrhage in Rats
Abstract NLRP3 inflammasomes have been reported to be an essential mediator in the inflammatory response during early brain injury (EBI) following subarachnoid hemorrhage (SAH). Recent studies have indicated that NLRP3 inflammasome-mediated pyroptosis and long non-coding RNA (lncRNA) H19 can participate in the inflammatory response. However, the roles and functions of lncRNA H19 in NLRP3 inflammasome-mediated pyroptosis during EBI after SAH are unknown and need to be further elucidated. NLRP3 inflammasome proteins were significantly elevated in CSF of human with SAH induced EBI and presented a positive correlation with s...
Source: Translational Stroke Research - November 24, 2022 Category: Neurology Source Type: research
Meta-review on Perforation Model of Subarachnoid Hemorrhage in Mice: Filament Material as a Possible Moderator of Mortality
AbstractRobust preclinical models are inevitable for researchers to unravel pathomechanisms of subarachnoidal hemorrhage (SAH). For the mouse perforation model of SAH, the goal of this meta-review was the determination of variances in mortality, SAH severity grade, and vasospasm, and their experimental moderators, as many researchers are facing with incomparable results. We searched on the databasesPubMed,Embase, andWeb of Science for articles describing in vivo experiments using the SAH perforation mouse model and measuring mortality, SAH grade, and/or vasospasm. After screening, 42 articles (total of 1964 mice) were incl...
Source: Translational Stroke Research - November 23, 2022 Category: Neurology Source Type: research
Sexuality & gt;1 year after brain injury rehabilitation: A cross-sectional study in Sweden
CONCLUSION: Visible impairments are known to impact sexual functions and satisfaction after ABI. Our results show how invisible impairments also have a great impact. From a biopsychosocial perspective, these results imply that individuals should receive sexual rehabilitation, irrespective of ABI impairment.PMID:36408962 | DOI:10.1080/02699052.2022.2145358
Source: Brain Injury - November 21, 2022 Category: Neurology Authors: Ann-Sofie Ek Charlotta Holmstr öm Eva Elmerstig Source Type: research
Aerobic Glycolysis Induced by mTOR/HIF-1 α Promotes Early Brain Injury After Subarachnoid Hemorrhage via Activating M1 Microglia
In conclusion, the present study showed new evidence that aerobic glycolysis induced by mTOR/HIF-1 α might promote EBI after SAH by activating M1 microglia. This finding provided new insights for the treatment of EBI.
Source: Translational Stroke Research - November 17, 2022 Category: Neurology Source Type: research
Effects of New-Generation Antiepileptic Drug Prophylaxis on Delayed Neurovascular Events After Aneurysmal Subarachnoid Hemorrhage
AbstractNeuroelectric disruptions such as seizures and cortical spreading depolarization may contribute to the development of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH). However, effects of antiepileptic drug prophylaxis on outcomes remain controversial in SAH. The authors investigated if prophylactic administration of new-generation antiepileptic drugs levetiracetam and perampanel was beneficial against delayed neurovascular events after SAH. This was a retrospective single-center cohort study of 121 consecutive SAH patients including 56 patients of admission World Federation of Neurolo...
Source: Translational Stroke Research - November 5, 2022 Category: Neurology Source Type: research
Risk factors for the rupture of mirror middle cerebral artery aneurysm using computer-assisted semiautomated measurement and hemodynamic analysis
Intracranial aneurysms (IAs) are associated with high rates of death and disability.1,2 Their rupture is accompanied by subarachnoid hemorrhage (SAH) and other severe complications.1,3 Predicting the aneurysms that are prone to rupture is crucial. A study showed that IAs are generated by morphologic changes secondary to blood flow-induced vessel remodeling.4 Hemodynamic and morphological numerically quantified rupture risk.5-7 However, the risks of rupture are also influenced by patient-related factors such as race, gender, hypertension, and smoking.
Source: Journal of Stroke and Cerebrovascular Diseases - November 2, 2022 Category: Neurology Authors: Sheng-Qi Hu, Ru-Dong Chen, Wei-Dong Xu, Jia-Sheng Yu Source Type: research
A novel risk score to predict deep vein thrombosis after spontaneous intracerebral hemorrhage
ConclusionThe ICH-DVT is a valid grading scale for predicting in-hospital DVT after ICH. Further studies on the effect of the ICH-DVT on clinical outcomes after ICH are warranted.
Source: Frontiers in Neurology - October 28, 2022 Category: Neurology Source Type: research
Use of A Systemic Inflammatory Response Index to Predict Non-Traumatic Non-Aneurysmal Subarachnoid Hemorrhage Patient Outcomes
Patients who suffer from non-traumatic non-aneurysmal subarachnoid hemorrhage (naSAH) episodes still face a risk of clinical complications and poor outcome. As the systemic inflammatory response index (SIRI) has recently been shown to offer value as a tool capable of predicting aneurysmal SAH (aSAH) patient outcomes, this study was designed to gauge SIRI prognostic utility in naSAH patients.
Source: Journal of Stroke and Cerebrovascular Diseases - October 28, 2022 Category: Neurology Authors: Tingting Yu, Zhengyang Wang Source Type: research
Safety Profile and Complication Rates in Emergency Off-label Use of Tirofiban in Interventional Neuroradiology
ConclusionWhereas the safety profile of tirofiban when applied off-label in INR is acceptable, the highest risk for relevant tirofiban-associated complications is observed in older patients treated by emergency stenting for acute stroke.
Source: Clinical Neuroradiology - October 21, 2022 Category: Neurology Source Type: research
A Genome-Wide Association Study of Outcome After Aneurysmal Subarachnoid Haemorrhage: Discovery Analysis
AbstractCandidate gene studies have identified genetic variants associated with clinical outcomes following aneurysmal subarachnoid haemorrhage (aSAH), but no genome-wide association studies have been performed to date. Here we report the results of the discovery phase of a two-stage genome-wide meta-analysis of outcome after aSAH. We identified 157 independent loci harbouring 756 genetic variants associated with outcome after aSAH (p < 1 × 10−4), which require validation. A single variant (rs12949158), inSPNS2, achieved genome-wide significance (p = 4.29 × 10−8) implicating sphingosine-1-phosphat...
Source: Translational Stroke Research - October 20, 2022 Category: Neurology Source Type: research
