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Using Dental Pulp Stem Cells for Stroke Therapy
Conclusion and Future Perspectives Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allo...
Source: Frontiers in Neurology - April 28, 2019 Category: Neurology Source Type: research

Differential coagulotoxicity of metalloprotease isoforms from Bothrops neuwiedi snake venom and consequent variations in antivenom efficacy.
This study broadens the current understanding about the adaptive role of the SVMPs, as well as highlights how the functional diversity of SVMP isoforms can influence clinical outcomes. Key Contribution: Our findings shed light upon the hemorrhagic and coagulotoxic effects of three SVMPs of the P-III class, as well as the coagulotoxic effects of SVMPs on human, avian and amphibian plasmas. Antivenom neutralised prothrombin-activating isoforms better than Factor X activating isoforms. PMID: 32841740 [PubMed - as supplied by publisher]
Source: Toxicology Letters - August 21, 2020 Category: Toxicology Authors: Sousa LF, Bernardoni JL, Zdenek CN, Dobson J, Coimbra F, Gillett A, Lopes-Ferreira M, Moura-da-Silva AM, Fry BG Tags: Toxicol Lett Source Type: research

Taxon-selective venom variation in adult and neonate Daboia russelii (Russell's Viper), and antivenom efficacy
Toxicon. 2021 Nov 6:S0041-0101(21)00305-6. doi: 10.1016/j.toxicon.2021.11.004. Online ahead of print.ABSTRACTMajor variations in venom composition can occur between juvenile and adult venomous snakes. However, due to logistical constraints, antivenoms are produced using adult venoms in immunising mixtures, possibly resulting in limited neutralisation of juvenile snake venoms. Daboia russelii is one of the leading causes of snakebite death across South Asia. Its venom is potently procoagulant, causing stroke in prey animals but causing in humans consumptive coagulopathy-a net anticoagulant state-and sometimes death resultin...
Source: Toxicon - November 9, 2021 Category: Toxicology Authors: Christina N Zdenek Abhinandan Chowdhury Grace Y H Haw Aude Violette Rudy Fourmy Thomas Christ Freek J Vonk Bryan G Fry Source Type: research

Molecular and pathological characterization of natural co-infection of poultry farms with the recently emerged Leucocytozoon caulleryi and chicken anemia virus in Egypt
AbstractIn the summers of 2018 and 2019, a disease outbreak stroke 25 broiler chicken farms and 3 broiler breeder farms in different Governorates in Egypt. The disease caused a mortality rate ranging from 3.2 to 9%. Postmortem examination showed petechial hemorrhage in the breast and thigh muscles, thymus gland, and peritoneal cavity and extensive hemorrhages in the kidneys. A total of 140 liver, kidney, lung, skeletal muscles, thymus, and spleen samples were collected. Twenty-eight pooled samples were created and examined by PCR and histopathological examination to identify the causative pathogens. All collected samples w...
Source: Tropical Animal Health and Production - February 8, 2022 Category: Veterinary Research Source Type: research